Any research on Rt3?

[sulamaye]

Just wondering if anyone has any links to research on Rt3, it's purpose, how it operates and what conditions up production would be great, but I'm aware this is a scant area so anything about it would be really helpful. Thank you!

[diogenes Remembering]

Here is a site to look at, though I personally don't fully agree with the conclusion that high rT3 indicates hypothyroidism directly. Hypothyroidism has many nonthyroidal knock on effects that are the triggers for increased rT3 - ie nonthyroidal illness can accompany thyroidal illness (a patient is not just suffering from thyroid deficiency but from all the other things that accompany it). BUT getting rid of the hypothyroidism won't necessarily lower rT3 if there happens to be an accompanying unconnected nonthyroidal illness that isn't being treated as well.

thyroid.about.com/od/t3trea...

[sulamaye in reply to diogenes]

Thanks but I wondered if there were any actual research papers into RT3?

[diogenes Remembering in reply to sulamaye]

Here are some to go on with:

Holm AC, Jacquemin C. Membrane transport of l-triiodothyronine by human red cell ghosts. Biochem Biophys Res Commun 1979;89:1006–1017.

Hennenmann G, Everts ME, de Jong M, et al. The significance of plasma membrane transport in the bioavailability of thyroid hormone. Clin Endo 1998;48:1-8.

Hennemann G, Vos RA, de Jong M, et al. Decreased peripheral 3,5,3’-triiodothyronine (T3) production from thyroxine (T4): A syndrome of impaired thyroid hormone activation due to transport inhibition of T4- into T3-producing tissues. J Clin Endocrinol Metabol 1993;77(5):1431-1435.

Krenning EP, Docter R, Bernard HF, et al. Decreased transport of thyroxine (T4), 3,3′,5-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs. FEBS Lett 1982;140:229-233.

De Jong M. Docter R, van der Hoek HJ, Vos RA. Transport of 3,5,3’-triiodothyronine into the perfused rat liver and subsequent metabolism are inhibited by fasting. Endocrinology 1992;131(1):463-470.

Hennemann G, Krenning EP, Bernard B, Huvers F, et al. Regulation of Influx and efflux of thyroid hormones in rat hepatocytes: Possible physiologic significance of plasma membrane in the regulation of thyroid hormone activity. Horm Metab Res Suppl 1984;14:1-6.

[sulamaye in reply to diogenes]

Thank you

[shaws Administrator]

Re T3, it may not answer your question fully, but may be useful. Go to the date March 24, 1999 to read the whole question/answer:-

Two excerpts:

Under normal conditions, cells continually convert about 40% of T4 to T3. They convert about 60% of T4 to reverse-T3. Hour-by-hour, conversion of T4 continues with slight shifts in the percentage of T4 converted to T3 and reverse-T3. Under normal conditions, the body eliminates reverse-T3 rapidly. Other enzymes quickly convert reverse-T3 to T2 and T2 to T1, and the body eliminates these molecules within roughly 24-hours. (The process of deiodination in the body is a bit more complicated than I can explain in this short summary.) The point is that the process of deiodination is dynamic and constantly changing, depending on the body's needs.

2.

Finally I decided that if some patients' fibromyalgia symptoms do indeed result from impaired conversion of T4 to T3, it is a rare phenomenon. I could no longer justify charging patients for the laboratory tests that would identify impaired conversion. As a result, I don't even bother ordering the tests any longer. This is the reason that you haven't read about impaired conversion of T4 to T3 and elevated reverse-T3 at this Web site or in more of our published articles.

web.archive.org/web/2010103...

[sulamaye in reply to shaws]

Lowe was on T3 only wasn't he? what, if anything, did he think we are missing if we dont have rt3 and therefore t1 and t2?

[shaws Administrator in reply to sulamaye]

Dr Lowe used mainly NDT for his patients. He did use T3 for those who were resistant for some reason.

As he died two years ago, I cannot give a response to your question. Two sentences from the above link:-

1. Finally I decided that if some patients' fibromyalgia symptoms do indeed result from impaired conversion of T4 to T3, it is a rare phenomenon

2.As a result, I don't even bother ordering the tests any longer. This is the reason that you haven't read about impaired conversion of T4 to T3 and elevated reverse-T3 at this Web site or in more of our published articles.

[sulamaye in reply to shaws]

Did he, I always got the impression he used T3, that's interesting Shaws. Is that what thyroid gold is? I took NDT for a couple of weeks in the run up to going T3 only to clear RT3 and support my adrenals with CT3M. NDT was very good, I noticed a difference immediately, which surprised me immensely as I am quite a skeptical soul, but certain symptoms stopped, they have reemerged with T3 so far. My plan is to get through the clearing and then leave my CT3M dose in place and replace the rest of my T3 doses with NDT. Have you any POV on such an approach? I'd appreciate your opinion

[PR4NOW in reply to sulamaye]

Shaws is correct, Dr. Lowe used mainly NDT and then T3 for those patients that showed resistance. He didn't bother with T4 monotherapy, didn't think it was beneficial. If I remember correctly he found about 30-35% showed resistance. Dr. Lowe took 150mcg T3 for himself all in one dose. Most people find that when on T3 multi-dosing works best, 3-5 split doses. T3 is usually the last resort simply because it is more complicated for dosing. There always seems to be a persistent minority that don't recover their health until they get on T3 only. Science has little if any understanding of this. Thyro-Gold is officially a bovine 'raw glandular', it costs millions to get USP certification. It is supposed to be uniform although I don't know anything about their standards of testing. There are a fair number that seem to use it successfully. Dr. Lowe took it himself for awhile before releasing it to the public. You can use either NDT or T3 with CT3M. What works best always turns out to be a very individual matter. RT3 is still a controversial subject, probably second to the subject of iodine. What we need is more and better science. There is an RT3 group on Yahoo. There are a fair number of patients that have reported improvement upon lowering their RT3/FT3 ratio. PR

[sulamaye in reply to PR4NOW]

Thanks - do you know how he determined who was resistant? Was it simply that they didn't respond to NDT? Because of low cortisol and sugar crashing I am finding it hard to make progress. Classic M.E complication, nothing straight forward! ahhhhh

[PR4NOW in reply to sulamaye]

Shaws may be able to give you a reference from the website, she is much more familiar with the site than I am. If I remember correctly it was a combination of how the patient reacted to NDT along with indirect calorimeter readings and monitoring serum levels. Dr. Lowe did pay great attention to a patient's signs and symptoms along with laboratory results. PR

Website for Thyro-Gold.

naturalthyroidsolutions.com...

[sulamaye in reply to PR4NOW]

thank you

[shaws Administrator in reply to sulamaye]

This is a link and you can click on the topics and gain lots of information. Just take a topic every few days.

web.archive.org/web/2010103...

[shaws Administrator in reply to sulamaye]

My sentence wasn't very clear. Yes Dr Lowe did take T3 himself. It was how he discovered how to heal himself although he didn't have a thyroid gland problem. He used NDT mainly for his patients but, T3 for the others.

[sulamaye]

Thanks Shaws

[damehypo in reply to sulamaye]

Have you looked here ?

tiredthyroid.com/rt3.html

[Angus1]

Google Miss Lizzie rt3 or utube dr Mercola and dr Lowe thyroid