Quantiferon TB Gold Plus -positive

[zafr]

Hello everyone,

my recent blood test Quantoferon TB Gold Plus result is positive , I had 3 months treatment course for Latent TB IN 2011, WHAT does it mean, Either TB existed in body or just antibodies positive

can Quantiferon TB gold PLus - positive be changed to Negative through TB treatment or it will remain positive ?

thanks in advance

[HelenC Partner TB Alert]

Dear Zafr,

This is some information from a professional Q&A brochure produced by the manufacturers, which can be found here: quantiferon.com/wp-content/...

Question: Does a positive QFT-Plus result become negative after treatment, i.e. with isoniazid

therapy, and if so how quickly does this occur?

Answer: In prior studies using QFT-Gold In-Tube, among individuals who have had isoniazid therapy for

LTBI, data suggest that responses decline with time but still remain above the test cutoff for a high proportion of individuals (39–41). Thus, the current level of evidence does not support using QFT-Plus for monitoring the response to treatment for those with LTBI.

So, in short, the body may continue to produce an immune response even after successful latent TB treatment. This could be picked up on a latent TB blood test and confused with latent TB.

If you were treated in the past and took all your medication as prescribed, and if you have no knowledge of being exposed to TB bacteria since then, it is likely that this is the situation for you.

Best wishes,

Helen

[zafr in reply to HelenC]

Thanks for you help and information

Do you know what s difference between T-Spot TB between QFT PLUS-TB

My T-Spot TB BLOOD Test is Positive and test result shows very high figure which is greater than 20 ( >20) Does it mean LTB infection is at very high risk

does LTBI transmit to others through fluid including sputum/ spittle/ semen , is it only it s contagious pulmunary TB BY AIR ONLY

Thanks in advance

[HelenC Partner TB Alert in reply to zafr]

Hi Zafr,

No, I am afraid that I do not know this level of details. However, I do now that the tests work in the same manner.

best wishes,

Helen