Experiences with

Trametinib

If you have been diagnosed with low grade serous ovarian cancer and you have been prescribed trametinib as part of your treatment, it would be great to hear from you. We would also love to hear experiences from friends, family members and carers.

Hi , I have low grade serous ovarian cancer. I had debulking surgery in Jan 2020. I have been taking letrozole since then . The disease is present in pare aortic and other lymph nodes but growing slowly . Recent scan found progression into spleen and increase of growth speed . I'm just about to

Have been diagnosed with 3c stage low grade ovarian cancer back in 2016, after debunking and several rounds of chemotherapy remission for 7 years, now the big C is back again, I have been offered the new drug Trametinib which I need to start soon, reading on the all side effects gives me a real scare

Trametinib is a targeted therapy which blocks a protein that helps cancer cells grow. Off-label drugs are prescribed by doctors in a different way than the conditions in its licence.

In preclinical study in turns out that Trametinib + Enza has a profound effect on proliferation, especially with PTEN loss and PI3K mutations, the pCa is then very dependent on the MAPK signalling pathway. There is a clinical trial II open for new patients, anybody in here on this trial?

There is a drug called Trametinib which is being used for this disease and my consultant has mentioned this could be a route for us to go, I wondered if anyone is currently on this medication and how they are finding it.

I’m starting Trametinib in the hope that it will work. Life is uncertain and unstable but I’m ready to start telling the stories again of the most inspiring people I know. In this episode Karen shared her story from diagnosis of Low Grade Ovarian Cancer to now.

My skin reaction has been awful, my face rash felt like a burn it got so bad . Dr has stopped drug to let it heal, the plan is a lower dose with antibiotics. I’m anxious about restarting and going through this weeks experience again as it was so bad. Rash advice, heal & repair skin, experience, reactions

Hello - This maybe a silly question but can I request Trametinib for myMum's LGSC (Fallopian Tube) - even if we had to pay for it ?

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer Prostate cancer and prostatic diseases 22(4), 531-538, 2019 "ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma."

In the phase II study of over 200 patients, median progression-free survival (PFS) for those receiving intermittent dosing of dabrafenib (Tafinlar) and trametinib (Mekinist) was 5.5 months, as compared to 9.0 months for patients receiving continuous treatment (HR 1.36, 80% CI 1.10-1.66, P=0.063), reported

Hi everyone Are any of you taking trametinib and if so would you mind telling me what side effects you have had? Thank you so much 😊😘

I have been on trametinib for 2 weeks and I am really struggling with the side effects. I would love to know if anyone else is on this and how they are coping. Thanks

Diagnoses was ( more disease than anticipated) As low grade I understand its chemo resistant I have been doing lots of research and found Trametinib could be an option for me but we cant access this via NHS. I have been meaning to get back on here for a while.

He has very kindly updated me and said this - “Re trametinib, the long term goal is to persuade the drug company who make it (Novartis) to go for a licensing application on the basis of our trial data so it gets licensed and thus can be given to patients with low grade serous ovarian cancer (although

Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors -- trametinib, cobimetinib, and binimetinib.

Combined BRAF/MEK inhibition is an option that is recommended for BRAF-mutant patients, in light of the COMBI-AD study which showed higher relapse-free survival at 4 years with dabrafenib and trametinib compared with treatment with placebo.

Health Canada has just approved the use of a combination therapy of Tafinlar® (dabrafenib) plus Mekinist® (trametinib) to prevent recurrence of melanoma following surgery in patients with a stage II or stage III diagnosis, also referred to as ‘adjuvant’ treatment.

Hi is it here anyone on here on a logs (trametinib) trial. I would love to know how others are getting on with this drug.

Trametinib? Anyone know anything about this?