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Trametinib
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Trametinib
Hi , I have low grade serous ovarian cancer. I had debulking surgery in Jan 2020. I have been taking letrozole since then . The disease is present in pare aortic and other lymph nodes but growing slowly . Recent scan found progression into spleen and increase of growth speed . I'm just about to
Hi , I have low grade serous ovarian cancer. I had debulking surgery in Jan 2020. I have been taking letrozole since then . The disease is present in pare aortic and other lymph nodes but growing slowly . Recent scan found progression into spleen and increase of growth speed . I'm just about to
joanbaez
in
My Ovacome
4 months ago
Trametinib!
Have been diagnosed with 3c stage low grade ovarian cancer back in 2016, after debunking and several rounds of chemotherapy remission for 7 years, now the big C is back again, I have been offered the new drug
Trametinib
which I need to start soon, reading on the all side effects gives me a real scare
Have been diagnosed with 3c stage low grade ovarian cancer back in 2016, after debunking and several rounds of chemotherapy remission for 7 years, now the big C is back again, I have been offered the new drug
Trametinib
which I need to start soon, reading on the all side effects gives me a real scare
Izoominka
in
My Ovacome
6 months ago
Update on trametinib (Mekinist) for low grade serous ovarian cancer
Trametinib
is a targeted therapy which blocks a protein that helps cancer cells grow. Off-label drugs are prescribed by doctors in a different way than the conditions in its licence.
Trametinib
is a targeted therapy which blocks a protein that helps cancer cells grow. Off-label drugs are prescribed by doctors in a different way than the conditions in its licence.
OvacomeSupport
My Ovacome Team
in
My Ovacome
6 months ago
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Trametinib MAPK inhibitor in ENZA-R pCA - very interesting
In preclinical study in turns out that
Trametinib
+ Enza has a profound effect on proliferation, especially with PTEN loss and PI3K mutations, the pCa is then very dependent on the MAPK signalling pathway. There is a clinical trial II open for new patients, anybody in here on this trial?
In preclinical study in turns out that
Trametinib
+ Enza has a profound effect on proliferation, especially with PTEN loss and PI3K mutations, the pCa is then very dependent on the MAPK signalling pathway. There is a clinical trial II open for new patients, anybody in here on this trial?
Hidden
in
Advanced Prostate Cancer
9 months ago
low grade serous ovarian cancer
There is a drug called
Trametinib
which is being used for this disease and my consultant has mentioned this could be a route for us to go, I wondered if anyone is currently on this medication and how they are finding it.
There is a drug called
Trametinib
which is being used for this disease and my consultant has mentioned this could be a route for us to go, I wondered if anyone is currently on this medication and how they are finding it.
Gillianpickle
in
My Ovacome
10 months ago
My podcast is back!
I’m starting
Trametinib
in the hope that it will work. Life is uncertain and unstable but I’m ready to start telling the stories again of the most inspiring people I know. In this episode Karen shared her story from diagnosis of Low Grade Ovarian Cancer to now.
I’m starting
Trametinib
in the hope that it will work. Life is uncertain and unstable but I’m ready to start telling the stories again of the most inspiring people I know. In this episode Karen shared her story from diagnosis of Low Grade Ovarian Cancer to now.
Levanah
in
My Ovacome
3 years ago
Any advice on Trametinib? Experiences.
My skin reaction has been awful, my face rash felt like a burn it got so bad . Dr has stopped drug to let it heal, the plan is a lower dose with antibiotics. I’m anxious about restarting and going through this weeks experience again as it was so bad. Rash advice, heal & repair skin, experience, reactions
My skin reaction has been awful, my face rash felt like a burn it got so bad . Dr has stopped drug to let it heal, the plan is a lower dose with antibiotics. I’m anxious about restarting and going through this weeks experience again as it was so bad. Rash advice, heal & repair skin, experience, reactions
Mum2G
in
My Ovacome
3 years ago
Access to Trametinib
Hello - This maybe a silly question but can I request
Trametinib
for myMum's LGSC (Fallopian Tube) - even if we had to pay for it ?
Hello - This maybe a silly question but can I request
Trametinib
for myMum's LGSC (Fallopian Tube) - even if we had to pay for it ?
cath_koala
in
My Ovacome
3 years ago
Off label use of Mekinist (Trametinib)
MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
Prostate cancer and prostatic diseases 22(4), 531-538, 2019 "ERK1 is the immediate downstream target of MEK1/2, which is druggable with
trametinib
, an approved therapeutic for melanoma."
MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
Prostate cancer and prostatic diseases 22(4), 531-538, 2019 "ERK1 is the immediate downstream target of MEK1/2, which is druggable with
trametinib
, an approved therapeutic for melanoma."
Graham49
in
Advanced Prostate Cancer
3 years ago
BRA/ Mek Treatment holiday flops in late stage melanoma trial
In the phase II study of over 200 patients, median progression-free survival (PFS) for those receiving intermittent dosing of dabrafenib (Tafinlar) and
trametinib
(Mekinist) was 5.5 months, as compared to 9.0 months for patients receiving continuous treatment (HR 1.36, 80% CI 1.10-1.66, P=0.063), reported
In the phase II study of over 200 patients, median progression-free survival (PFS) for those receiving intermittent dosing of dabrafenib (Tafinlar) and
trametinib
(Mekinist) was 5.5 months, as compared to 9.0 months for patients receiving continuous treatment (HR 1.36, 80% CI 1.10-1.66, P=0.063), reported
missyrand
Ambassador
in
Melanoma Caregivers
4 years ago
Trametinib
Hi everyone Are any of you taking
trametinib
and if so would you mind telling me what side effects you have had? Thank you so much 😊😘
Hi everyone Are any of you taking
trametinib
and if so would you mind telling me what side effects you have had? Thank you so much 😊😘
Jonich
in
My Ovacome
4 years ago
Anyone else on Trametinib?
I have been on
trametinib
for 2 weeks and I am really struggling with the side effects. I would love to know if anyone else is on this and how they are coping. Thanks
I have been on
trametinib
for 2 weeks and I am really struggling with the side effects. I would love to know if anyone else is on this and how they are coping. Thanks
Twinkle63
in
My Ovacome
4 years ago
Diagnosed - Low Grade Ovarian Cancer
Diagnoses was ( more disease than anticipated) As low grade I understand its chemo resistant I have been doing lots of research and found
Trametinib
could be an option for me but we cant access this via NHS. I have been meaning to get back on here for a while.
Diagnoses was ( more disease than anticipated) As low grade I understand its chemo resistant I have been doing lots of research and found
Trametinib
could be an option for me but we cant access this via NHS. I have been meaning to get back on here for a while.
Jasmine_Rose
in
My Ovacome
4 years ago
Low Grade OC -Trametanib update!
He has very kindly updated me and said this - “Re
trametinib
, the long term goal is to persuade the drug company who make it (Novartis) to go for a licensing application on the basis of our trial data so it gets licensed and thus can be given to patients with low grade serous ovarian cancer (although
He has very kindly updated me and said this - “Re
trametinib
, the long term goal is to persuade the drug company who make it (Novartis) to go for a licensing application on the basis of our trial data so it gets licensed and thus can be given to patients with low grade serous ovarian cancer (although
Levanah
in
My Ovacome
4 years ago
BRAF/MEK combo raises risk of cardiovascular adverse events compared to BRAF monotherapy only
Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors --
trametinib
, cobimetinib, and binimetinib.
Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors --
trametinib
, cobimetinib, and binimetinib.
missyrand
Ambassador
in
Melanoma Caregivers
5 years ago
Do you know your tumor BRAF status? You probably should
Combined BRAF/MEK inhibition is an option that is recommended for BRAF-mutant patients, in light of the COMBI-AD study which showed higher relapse-free survival at 4 years with dabrafenib and
trametinib
compared with treatment with placebo.
Combined BRAF/MEK inhibition is an option that is recommended for BRAF-mutant patients, in light of the COMBI-AD study which showed higher relapse-free survival at 4 years with dabrafenib and
trametinib
compared with treatment with placebo.
missyrand
Ambassador
in
Melanoma Caregivers
5 years ago
GREAT NEWS: HEALTH CANADA APPROVES FIRST ADJUVANT TREATMENT FOR MELANOMA TO PREVENT RELAPSE FOLLOWING SURGERY!
Health Canada has just approved the use of a combination therapy of Tafinlar® (dabrafenib) plus Mekinist® (
trametinib
) to prevent recurrence of melanoma following surgery in patients with a stage II or stage III diagnosis, also referred to as ‘adjuvant’ treatment.
Health Canada has just approved the use of a combination therapy of Tafinlar® (dabrafenib) plus Mekinist® (
trametinib
) to prevent recurrence of melanoma following surgery in patients with a stage II or stage III diagnosis, also referred to as ‘adjuvant’ treatment.
amykjones
Administrator
in
Melanoma Wellness Canada
5 years ago
Trametinib
Hi is it here anyone on here on a logs (
trametinib
) trial. I would love to know how others are getting on with this drug.
Hi is it here anyone on here on a logs (
trametinib
) trial. I would love to know how others are getting on with this drug.
twiggy66
in
My Ovacome
6 years ago
Compassionate Use
Trametinib
? Anyone know anything about this?
Trametinib
? Anyone know anything about this?
Blair77
in
Advanced Prostate Cancer
6 years ago
Update: Change of treatment again
Friends: I had a difficult couple of months on the MSKCC clinical trial ( combo of Tarceva and MEK inhibitor
trametinib
) that concluded with leaving the trial. My first scan showed some shrinkage in the lung, but still those pesky lymph nodes all grew.
Friends: I had a difficult couple of months on the MSKCC clinical trial ( combo of Tarceva and MEK inhibitor
trametinib
) that concluded with leaving the trial. My first scan showed some shrinkage in the lung, but still those pesky lymph nodes all grew.
scifiknitter
Blogger
in
Lung Cancer Support
6 years ago
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