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Grapefruit juice is more than a CYP3A4 inhibitor
Just found this timely article all about Grapefruit for Parkinson's, except effects on
levodopa
, 'cos it hasn't been tested. Conclusion : it's good for your brain, but could be dangerous, so if in doubt, don't drink it. https://www.salubrainous.com/grapefruit-for-parkinsons/
Just found this timely article all about Grapefruit for Parkinson's, except effects on
levodopa
, 'cos it hasn't been tested. Conclusion : it's good for your brain, but could be dangerous, so if in doubt, don't drink it. https://www.salubrainous.com/grapefruit-for-parkinsons/
wriga
in
Cure Parkinson's
5 years ago
More pieces to the puzzle about getting a more stable supply of levodopa to the brain
The results confirm that CYP3A4 powerfully inhibits
levodopa
and may be more important in its action than DDC, the enzyme that is inhibited by Carbidopa.
The results confirm that CYP3A4 powerfully inhibits
levodopa
and may be more important in its action than DDC, the enzyme that is inhibited by Carbidopa.
wriga
in
Cure Parkinson's
5 years ago
L-carnosine
It seems like L-carnosine, a natural molecule of the brain, may have some significant benefits for PWP: https://www.mdpi.com/2072-6643/10/2/147 https://www.ncbi.nlm.nih.gov/pubmed/18729814 Following is the relevant quotation from self hacked.com: 10) May Treat Parkinson’s Disease Carnosine reduces
It seems like L-carnosine, a natural molecule of the brain, may have some significant benefits for PWP: https://www.mdpi.com/2072-6643/10/2/147 https://www.ncbi.nlm.nih.gov/pubmed/18729814 Following is the relevant quotation from self hacked.com: 10) May Treat Parkinson’s Disease Carnosine reduces
MehmetKutlu
in
Cure Parkinson's
5 years ago
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Madopar
Hello all My husband has been prescribed Madopar 50 mg which is
levodopa
and benserazide. He has CBD this is to help jerks. I have not given this to him as the jerks are not too bad. Has anyone had a positive experience with this medication please
Hello all My husband has been prescribed Madopar 50 mg which is
levodopa
and benserazide. He has CBD this is to help jerks. I have not given this to him as the jerks are not too bad. Has anyone had a positive experience with this medication please
Northstar1
in
PSP Association
5 years ago
Why should not we increase L-Dopa bioavailability in the Brain
After watching this video you will find out why you shouldn’t manipulate the L Dopa bioavailability in the brain. https://youtu.be/_eq28PCvfsg You are trying to balance something but you will end up messing with the same thing, in this case the Dopamine.
After watching this video you will find out why you shouldn’t manipulate the L Dopa bioavailability in the brain. https://youtu.be/_eq28PCvfsg You are trying to balance something but you will end up messing with the same thing, in this case the Dopamine.
Kia17
in
Cure Parkinson's
5 years ago
Can you take sinemet and sertraline (Zoloft) together ?
Can you take them together or do they need to be spaced out. Hubby has been leaving a gap between sinemet and breakfast with his sertraline and vitamins but I’m wondering if he can take the sertraline at the same time as the sinemet to get it into him earlier in the morning. He is struggling with the
Can you take them together or do they need to be spaced out. Hubby has been leaving a gap between sinemet and breakfast with his sertraline and vitamins but I’m wondering if he can take the sertraline at the same time as the sinemet to get it into him earlier in the morning. He is struggling with the
LAJ12345
in
Cure Parkinson's
5 years ago
Scratching your head for the origin of Parkinsons - is there a common link between Dandruff and PD ?
This Canadian-Spanish team examines the hypothesis that the micro-fungus, Malassezzia which causes dandruff and seborrheic dermatitis (SD) xould get into the brain and damage cells. The association between the two conditions may also be due to a common factor that helps promote both conditions. Not
This Canadian-Spanish team examines the hypothesis that the micro-fungus, Malassezzia which causes dandruff and seborrheic dermatitis (SD) xould get into the brain and damage cells. The association between the two conditions may also be due to a common factor that helps promote both conditions. Not
wriga
in
Cure Parkinson's
5 years ago
Doctors use levodopa responsiveness to diagnose, but a new report today says a specific gut bacteria prevents it from getting to the brain
I often feel I am sometimes unresponsive to
levodopa
. I wonder if these bacteria come and go.
I often feel I am sometimes unresponsive to
levodopa
. I wonder if these bacteria come and go.
MBAnderson
in
Cure Parkinson's
5 years ago
Gut microbes interfere with Parkinson's drug - but we could stop them
Levodopa
is used to treat many of the symptoms experienced by the 10 million people with Parkinson’s. The drug works by passing the blood-brain barrier and releasing dopamine in the brain.
Levodopa
is used to treat many of the symptoms experienced by the 10 million people with Parkinson’s. The drug works by passing the blood-brain barrier and releasing dopamine in the brain.
Farooqji
in
Cure Parkinson's
5 years ago
Phase 3 Clinical Trial Evaluating Continuous Subcutaneous Carbidopa/Levodopa (ND0612) Initiated In The United States For Parkinson's Disease
https://finance.yahoo.com/news/phase-3-clinical-trial-evaluating-140000074.html
https://finance.yahoo.com/news/phase-3-clinical-trial-evaluating-140000074.html
Farooqji
in
Cure Parkinson's
5 years ago
APL-130277 still without FDA Approval: Why?
Apomorphine is a somewhat strange Dopamine Agonist (non-egoline DA Parky B!) that required subcutaneous injections. It certainly hasn't been a mainline DA prescription in the USA. Sunovian developed back in 2012 a 2 part sublingual film that was applied under the tongue to reduce the difficulties of
Apomorphine is a somewhat strange Dopamine Agonist (non-egoline DA Parky B!) that required subcutaneous injections. It certainly hasn't been a mainline DA prescription in the USA. Sunovian developed back in 2012 a 2 part sublingual film that was applied under the tongue to reduce the difficulties of
sharoncrayn
in
Cure Parkinson's
5 years ago
Apomorphin and L Dopa, both s.c.
Has anybody tested this new therapeutic option? In Autria as apoorphinr and D-mine are available.
Has anybody tested this new therapeutic option? In Autria as apoorphinr and D-mine are available.
matthias_baum
in
Cure Parkinson's
5 years ago
Is levodopa toxic? The story so far. Medscape, June 22, 2019 (includes several videos)
You have to copy this link and put it in another browser. https://www.medscape.org/viewarticle/433387_2
You have to copy this link and put it in another browser. https://www.medscape.org/viewarticle/433387_2
MBAnderson
in
Cure Parkinson's
5 years ago
Study provides some answers regarding role of gut bacteria and levodopa
https://www.nature.com/articles/d41586-019-01887-z
https://www.nature.com/articles/d41586-019-01887-z
karolmilk
in
Cure Parkinson's
5 years ago
Generic Treatment for Parkinson Disease Receives FDA Approval
Alembic Pharmaceuticals has received FDA approval for its Carbidopa and
Levodopa
Extended-Release Tablets USP, 2.5 mg/100 mg and 50 mg/200 mg, according to the company.
Alembic Pharmaceuticals has received FDA approval for its Carbidopa and
Levodopa
Extended-Release Tablets USP, 2.5 mg/100 mg and 50 mg/200 mg, according to the company.
Farooqji
in
Cure Parkinson's
5 years ago
Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson's disease: a meta-analys
S + L combination therapy is superior to L monotherapy for the improvement of clinical symptoms in PD patients. Moreover, the safety profile of S + L combination therapy is comparable with that of L monotherapy. https://www.ncbi.nlm.nih.gov/pubmed/31175606
S + L combination therapy is superior to L monotherapy for the improvement of clinical symptoms in PD patients. Moreover, the safety profile of S + L combination therapy is comparable with that of L monotherapy. https://www.ncbi.nlm.nih.gov/pubmed/31175606
Farooqji
in
Cure Parkinson's
5 years ago
Barlowe's herbals elixirs Macuna Pruriens
Seed extract 650mg. 40% PILL form it's white, I thought I was getting the whole herb which is brown, this looks like it's pure L-dopa. Has anyone tried this, and how much would replace 25/100 cardopa/levadopa. I take 2 25/100 every 3 half hours. I would like to try cutting back one pill and replace
Seed extract 650mg. 40% PILL form it's white, I thought I was getting the whole herb which is brown, this looks like it's pure L-dopa. Has anyone tried this, and how much would replace 25/100 cardopa/levadopa. I take 2 25/100 every 3 half hours. I would like to try cutting back one pill and replace
akgirlsrock
in
Cure Parkinson's
5 years ago
Ibogaine HCL + Syrian rue treatment - First feedback
taking nex medications for Parkinson's: 4 x Madopar 100 mg L / 25 C 3 x Requip 4 (dopamine antagonist) 1 x Azilect (rasagaline) Mao inhibitor The Pills (except Madopar) have gradually been abandoned, the current protocol is: 4 x Madopar 100 mg (Together with Madopar - Mucuna pruriens - pure
levodopa
taking nex medications for Parkinson's: 4 x Madopar 100 mg L / 25 C 3 x Requip 4 (dopamine antagonist) 1 x Azilect (rasagaline) Mao inhibitor The Pills (except Madopar) have gradually been abandoned, the current protocol is: 4 x Madopar 100 mg (Together with Madopar - Mucuna pruriens - pure
levodopa
Gypsyzebra
in
Cure Parkinson's
5 years ago
PD Without Rigidity.
Are there any PWP here that don't have rigidity? I don't mean body stiffness but mean no trouble with handwriting, no cogwheel rigidity in any joints? I have stiff neck 24/7 and axial (central body) stiffness that affects walking making me slow and off balance but no rigidity as yet. L-Dopa relieves
Are there any PWP here that don't have rigidity? I don't mean body stiffness but mean no trouble with handwriting, no cogwheel rigidity in any joints? I have stiff neck 24/7 and axial (central body) stiffness that affects walking making me slow and off balance but no rigidity as yet. L-Dopa relieves
rideabike
in
Cure Parkinson's
5 years ago
Please spell it out for me.
I currently take 2 tablets of generic for Sinemet 25mg carbidopa 100mg
levodopa
4 times per day at about 6 a.m., noon, 6 p.m. and midnight or when I wake during the night. I am also doing the HCL thiamine and after much experimentation settled on 1 500mg capsule in the a.m.
I currently take 2 tablets of generic for Sinemet 25mg carbidopa 100mg
levodopa
4 times per day at about 6 a.m., noon, 6 p.m. and midnight or when I wake during the night. I am also doing the HCL thiamine and after much experimentation settled on 1 500mg capsule in the a.m.
ladyaudree
in
Cure Parkinson's
5 years ago
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