Experiences with

Leuprolide

I am currently in my 16th month of leuprolide treatment. At the beginning of my treatment a bone density scan found that I was "mildly osteopenic" . My oncologist has suggested that I take 1200mg calcium/day supplement.

Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as leuprolide or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.

Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as leuprolide or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.

PSA roughly halved after each of the first two infusion, prior to 3rd was added leuprolide 11.25 mg. Last PSA test was on 4th of June and it was 3.62 ng/mL and testosterone at 11.

Hi, I am beginning hormone therapy, which should hopefully reduce the size of my prostate. I have been given 11.5mg of Leuprorelin and 2 weeks of bicalutamide to reduce the testosterone flair up. How long should this take to actually reduce the size of my prostate?

* FSH suppression was greater with relugolix than with leuprolide at all available time points. * Major cardiovascular events were seen in 2.9%, relugolix, compared to 6.2%, Lupron, representing a 54% reduction of cardiovascular event risk.

I am just finishing 37 radiotherapy sessions and have been on hormone for 5 months. I had a couple of irritating spots under one of my arm pits for the past 2 months. In the past few days a rash has spread across my chest and neck and groin. Anyone else experience this during treatment? Thanks

Real-world Cardiovascular Outcomes Associated With Degarelix vs Leuprolide for Prostate Cancer Treatment An interesting study that concludes there is no difference in cardio impact between the two drugs. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785385

The article below is from a blog by Dr Michael Glode, a medical oncologist specialist, who was the principal investigator on both the study leading to the approval of Leuprolide and on the National Cancer Institute sponsored adjuvant treatment protocol for high-risk prostate cancer patients following

He was put on ADT (Leuprolide and Abiraterone). Looking at his age and health chemo is not an option. After 6.5 months his PSA is down to 1.2 and fresh CT comparison states the following: "[i]Prostatic lesion shows decrease in size and PSMA uptake (approx. 20% decrease in size).

Would anyone share their experiences with Lupron depot (leuprolide acetate) with Xtandi ( enzalutamide) ADT therapy please? Am 72 with advanced metastatic prostate carcinoma in my lymph nodes and cervical spinal column. Gleason 8, Testosterone still high. . PSA was 350 now 150.

Responding well to ADT so far (Leuprolide and Abiraterone). Should I take a second opinion from another doc? Many thanks, A

Isn't strange that Eligard/Leuprolide doesn't have any effect at all? Is there any alternative to Eligard/Leuprolide?

He was put on 3monthly leuprolide acetate injection and given bicalutamide for the first two weeks. As he is anemic we got him some iron infused intravenously so that his hemoglobin is at an acceptable level.

agonists happens too frequently, researchers report by Mike Bassett, Staff Writer, MedPage Today April 22, 2021 [/i] [i]https://www.medpagetoday.com/meetingcoverage/ons/92221[/i] Full Report in Journal of Urology is here: [i]Impact of Late Dosing on Testosterone Suppression with 2 Different

Leuprolide and abiraterone + prednisone for 2 years with most all the usual ADT SEs and PSA < 0.1 so far. A couple of months ago, I noticed significant but not severe swelling of my R calf and minor swelling of L calf.

https://www.rtihs.org/publications/comparison-impact-degarelix-and-leuprolide-health-related-quality-life-patients However, I am very hesitant in switching to leuprolide since Firmagon appears to have other significant long-term benefits which is why I chose this therapy.

Intolerant/allergic to leuprolide so I did alternative ADT after BCR with bicalutamide 50mg plus dutasteride for 5 years before it failed. In 2019 I had Ga-68-PSMA scan showing only two PLNs in pelvis on left side. No activity elsewhere. So I did hemipelvis IMRT, 64 Gy with boost to the 2 nodes.

earlier used with prednisolone and also not aware about steroid switch) [u]Dad treatment history: [/u] Dx at Jan 2018 at age of 49yr, Baseline PSA 2500,GS-10,St-4, adenocarcinoma ca prostate with extensive LN mets and bone mets (bone marrow involved), started with Abiretrone/prednisolone + leuprolide

Was going to start Leuprolide (Eligard) shot today but insurance was still pending ,they should be calling me real soon to reschedule. I’m sure TAll Allen has it pegged ADT with whole salvage pelvic radiation is coming. BTW T level is 245 as I haven’t had any treatments yet!