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Leuprolide
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Agonists vs. antagonists (the latter not to be confused with a character in a novel!)
I started ADT exactly 8 years ago this month and during my off-and-on treatments since then have tried a half-dozen different drugs in the older agonist category (
leuprolide
, for example) attempting to find one with the fewest (or at least the most tolerable) side-effects.
I started ADT exactly 8 years ago this month and during my off-and-on treatments since then have tried a half-dozen different drugs in the older agonist category (
leuprolide
, for example) attempting to find one with the fewest (or at least the most tolerable) side-effects.
bluesnjazz
in
Advanced Prostate Cancer
3 months ago
Xtandi failure?
After a successful - but short - period on Bicalutamide + Leuprorelin my PSA has risen from 1.1 to 1.7, to (now) 3.3. My last scan showed some micro-mets on my back, but organs were clear.Is it safe to say that Xtandi does not work for me? To be honest, I've had a miserable time on it, culminating in
After a successful - but short - period on Bicalutamide + Leuprorelin my PSA has risen from 1.1 to 1.7, to (now) 3.3. My last scan showed some micro-mets on my back, but organs were clear.Is it safe to say that Xtandi does not work for me? To be honest, I've had a miserable time on it, culminating in
CrocodileShoes
in
Advanced Prostate Cancer
1 year ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-enzalutamide-plus-
leuprolide
https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-enzalutamide-plus-
leuprolide
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
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CVD & GnRH agonists/antagonists
New study below [1]. Men with PCa have a greater risk of death from cardiovascular [CV] events, and androgen deprivation therapy [ADT] further increases that risk. The study looked at ADT drugs that target gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. The drugs were Degarelix
New study below [1]. Men with PCa have a greater risk of death from cardiovascular [CV] events, and androgen deprivation therapy [ADT] further increases that risk. The study looked at ADT drugs that target gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. The drugs were Degarelix
pca2004
in
Fight Prostate Cancer
1 year ago
What first?: Provenge or Nubeqa?
In general, androgen deprivation therapy (ADT) with
leuprolide
or GNRH antagonists remains a first-line therapy for patients who are still sensitive to androgen. For these patients, the antiresorptive agents denosumab and zoledronic acid can be used to help manage skeletal-related events (SREs).
In general, androgen deprivation therapy (ADT) with
leuprolide
or GNRH antagonists remains a first-line therapy for patients who are still sensitive to androgen. For these patients, the antiresorptive agents denosumab and zoledronic acid can be used to help manage skeletal-related events (SREs).
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
What should We do now?
My father,aged 59 was recently diagnosed with mHSPC.Our MO started 1st
leuprolide
injection on 5th July and he started bicalutamide along with it.Then he asked to stop bicalutamide and visit him with a PSA test. When we 1st checked psa it was 1389.
My father,aged 59 was recently diagnosed with mHSPC.Our MO started 1st
leuprolide
injection on 5th July and he started bicalutamide along with it.Then he asked to stop bicalutamide and visit him with a PSA test. When we 1st checked psa it was 1389.
sarkarsaikat2
in
Advanced Prostate Cancer
2 years ago
More calcium chat
I am currently in my 16th month of
leuprolide
treatment. At the beginning of my treatment a bone density scan found that I was "mildly osteopenic" . My oncologist has suggested that I take 1200mg calcium/day supplement.
I am currently in my 16th month of
leuprolide
treatment. At the beginning of my treatment a bone density scan found that I was "mildly osteopenic" . My oncologist has suggested that I take 1200mg calcium/day supplement.
mike__c
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as
leuprolide
or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.
Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as
leuprolide
or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as
leuprolide
or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.
Also, some trial protocols have used bicalutamide and similar to block testosterone effects from the androgen “flare” when an ADT drug such as
leuprolide
or goserelin are first started. Note that the LHRH antagonists degarelix and relugolix do not have the androgen flare.
MateoBeach
in
Fight Prostate Cancer
2 years ago
Lu-177 in Austria - Report and underlining high importance of both FDG and PSMA PET/CTs
PSA roughly halved after each of the first two infusion, prior to 3rd was added
leuprolide
11.25 mg. Last PSA test was on 4th of June and it was 3.62 ng/mL and testosterone at 11.
PSA roughly halved after each of the first two infusion, prior to 3rd was added
leuprolide
11.25 mg. Last PSA test was on 4th of June and it was 3.62 ng/mL and testosterone at 11.
CurrentSEO
in
Advanced Prostate Cancer
2 years ago
Prostate size reduction by hormone treatment - how long should this take?
Hi, I am beginning hormone therapy, which should hopefully reduce the size of my prostate. I have been given 11.5mg of Leuprorelin and 2 weeks of bicalutamide to reduce the testosterone flair up. How long should this take to actually reduce the size of my prostate?
Hi, I am beginning hormone therapy, which should hopefully reduce the size of my prostate. I have been given 11.5mg of Leuprorelin and 2 weeks of bicalutamide to reduce the testosterone flair up. How long should this take to actually reduce the size of my prostate?
swellonion230
in
Men's Health Forum
2 years ago
LUPRON vs FIRMAGON: Is The Debate About Superiority Over? With the December FDA approval of Relugolix the debate may now be moot
* FSH suppression was greater with relugolix than with
leuprolide
at all available time points. * Major cardiovascular events were seen in 2.9%, relugolix, compared to 6.2%, Lupron, representing a 54% reduction of cardiovascular event risk.
* FSH suppression was greater with relugolix than with
leuprolide
at all available time points. * Major cardiovascular events were seen in 2.9%, relugolix, compared to 6.2%, Lupron, representing a 54% reduction of cardiovascular event risk.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Experiencing a rash while on Leuprorelin (Prostap, Lutrate) hormone therapy.
I am just finishing 37 radiotherapy sessions and have been on hormone for 5 months. I had a couple of irritating spots under one of my arm pits for the past 2 months. In the past few days a rash has spread across my chest and neck and groin. Anyone else experience this during treatment? Thanks
I am just finishing 37 radiotherapy sessions and have been on hormone for 5 months. I had a couple of irritating spots under one of my arm pits for the past 2 months. In the past few days a rash has spread across my chest and neck and groin. Anyone else experience this during treatment? Thanks
Runner1957
in
Advanced Prostate Cancer
2 years ago
Real-world Cardiovascular Outcomes Associated With Degarelix vs Leuprolide
Real-world Cardiovascular Outcomes Associated With Degarelix vs
Leuprolide
for Prostate Cancer Treatment An interesting study that concludes there is no difference in cardio impact between the two drugs. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785385
Real-world Cardiovascular Outcomes Associated With Degarelix vs
Leuprolide
for Prostate Cancer Treatment An interesting study that concludes there is no difference in cardio impact between the two drugs. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785385
Don_1213
in
Advanced Prostate Cancer
3 years ago
Here's What you should 'eat' to fight prostate cancer....
The article below is from a blog by Dr Michael Glode, a medical oncologist specialist, who was the principal investigator on both the study leading to the approval of
Leuprolide
and on the National Cancer Institute sponsored adjuvant treatment protocol for high-risk prostate cancer patients following
The article below is from a blog by Dr Michael Glode, a medical oncologist specialist, who was the principal investigator on both the study leading to the approval of
Leuprolide
and on the National Cancer Institute sponsored adjuvant treatment protocol for high-risk prostate cancer patients following
marnieg46
in
Fight Prostate Cancer
3 years ago
What do you advise? What are your experiences?
Would anyone share their experiences with Lupron depot (
leuprolide
acetate) with Xtandi ( enzalutamide) ADT therapy please? Am 72 with advanced metastatic prostate carcinoma in my lymph nodes and cervical spinal column. Gleason 8, Testosterone still high. . PSA was 350 now 150.
Would anyone share their experiences with Lupron depot (
leuprolide
acetate) with Xtandi ( enzalutamide) ADT therapy please? Am 72 with advanced metastatic prostate carcinoma in my lymph nodes and cervical spinal column. Gleason 8, Testosterone still high. . PSA was 350 now 150.
Rudradas
in
Advanced Prostate Cancer
3 years ago
6 monthly update and potential treatment questions
He was put on ADT (
Leuprolide
and Abiraterone). Looking at his age and health chemo is not an option. After 6.5 months his PSA is down to 1.2 and fresh CT comparison states the following: "[i]Prostatic lesion shows decrease in size and PSMA uptake (approx. 20% decrease in size).
He was put on ADT (
Leuprolide
and Abiraterone). Looking at his age and health chemo is not an option. After 6.5 months his PSA is down to 1.2 and fresh CT comparison states the following: "[i]Prostatic lesion shows decrease in size and PSMA uptake (approx. 20% decrease in size).
Rodeoz15
in
Advanced Prostate Cancer
2 years ago
Eligard/Leuprolide no effect at all
Isn't strange that Eligard/
Leuprolide
doesn't have any effect at all? Is there any alternative to Eligard/
Leuprolide
?
Isn't strange that Eligard/
Leuprolide
doesn't have any effect at all? Is there any alternative to Eligard/
Leuprolide
?
Jurasuje
in
Advanced Prostate Cancer
3 years ago
Dexa Scan Query
Responding well to ADT so far (
Leuprolide
and Abiraterone). Should I take a second opinion from another doc? Many thanks, A
Responding well to ADT so far (
Leuprolide
and Abiraterone). Should I take a second opinion from another doc? Many thanks, A
Rodeoz15
in
Advanced Prostate Cancer
3 years ago
Father recently diagnosed with metastatic PC
He was put on 3monthly
leuprolide
acetate injection and given bicalutamide for the first two weeks. As he is anemic we got him some iron infused intravenously so that his hemoglobin is at an acceptable level.
He was put on 3monthly
leuprolide
acetate injection and given bicalutamide for the first two weeks. As he is anemic we got him some iron infused intravenously so that his hemoglobin is at an acceptable level.
Rodeoz15
in
Advanced Prostate Cancer
3 years ago
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