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Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
Earlier trials of the cytotoxic T-lymphocyte–associated antigen 4 inhibitor
ipilimumab
and the PD-1 inhibitor nivolumab were disappointing. The authors highlight the phase III CA184-095 trial, which illustrated no survival advantage for
ipilimumab
vs placebo in chemotherapy-naive patients.
Earlier trials of the cytotoxic T-lymphocyte–associated antigen 4 inhibitor
ipilimumab
and the PD-1 inhibitor nivolumab were disappointing. The authors highlight the phase III CA184-095 trial, which illustrated no survival advantage for
ipilimumab
vs placebo in chemotherapy-naive patients.
JLS1
in
Advanced Prostate Cancer
5 years ago
Names of targeted therapies ...mab and ...ib
I think it gives a really clear and useful explanation of names like "
ipilimumab
" and "imatinib". https://voice.ons.org/news-and-views/the-names-of-targeted-therapies-give-clues-to-how-they-work Alan
I think it gives a really clear and useful explanation of names like "
ipilimumab
" and "imatinib". https://voice.ons.org/news-and-views/the-names-of-targeted-therapies-give-clues-to-how-they-work Alan
AlanMeyer
in
Advanced Prostate Cancer
5 years ago
Starting ipi/nivo next week
I did participate in the study for
ipilimumab
many years ago before the FDA approved it with no side effects, so I hope to tolerate the infusions well. My body is healthy, and my blood work comes back recently with all panels reading like one before the taf/mek.
I did participate in the study for
ipilimumab
many years ago before the FDA approved it with no side effects, so I hope to tolerate the infusions well. My body is healthy, and my blood work comes back recently with all panels reading like one before the taf/mek.
Ryan2
in
Young Adults with Melanoma
5 years ago
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Immunotherapy for prostate cancer continues to disappoint, but at least we are learning why
I've updated this article about the importance of timing in prostate cancer therapies with the early results of the "CHECKMATE 650" clinical trial that combined nivolumab (Opdivo) and
ipilimumab
(Yervoy).
I've updated this article about the importance of timing in prostate cancer therapies with the early results of the "CHECKMATE 650" clinical trial that combined nivolumab (Opdivo) and
ipilimumab
(Yervoy).
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
immunotherapy combo worked in 25% of asymptomatic and minimally symptomatic patients who progressed after second-generation hormonal therapy
Really good news: The combination of nivolumab (Opdivo) plus
ipilimumab
(Yervoy) demonstrated activity in a biomarker-enriched population of patients with metastatic castration-resistant prostate cancer (mCRPC); however, researchers need to refine the toxicity profile, said Sumit K.
Really good news: The combination of nivolumab (Opdivo) plus
ipilimumab
(Yervoy) demonstrated activity in a biomarker-enriched population of patients with metastatic castration-resistant prostate cancer (mCRPC); however, researchers need to refine the toxicity profile, said Sumit K.
George71
in
Advanced Prostate Cancer
5 years ago
Nivolumab plus ipilimumab.
Men received 1 mg/kg nivolumab plus 3 mg/kg
ipilimumab
every 3 weeks for four doses, followed by 480 mg nivolumab monotherapy every 4 weeks.
Men received 1 mg/kg nivolumab plus 3 mg/kg
ipilimumab
every 3 weeks for four doses, followed by 480 mg nivolumab monotherapy every 4 weeks.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
My Experience With Melanoma
My oncologist suggested that I go into a trial for
ipilimumab
. I could get a high dose, a low dose, or interferon randomly. I got chosen for what later turned out to be the FDA approved dose of what is now commercially called Yervoy. I finished each dose with no side effects.
My oncologist suggested that I go into a trial for
ipilimumab
. I could get a high dose, a low dose, or interferon randomly. I got chosen for what later turned out to be the FDA approved dose of what is now commercially called Yervoy. I finished each dose with no side effects.
Ryan2
in
Young Adults with Melanoma
5 years ago
Prostate cancer Checkmate ( 650 )
www.winknews.com/2018/12/06/checkmate-for-prostate-cancer/ The clinical trial , may be one these NCT02601014 , NCT03532217 , NCT02985957 , NCT03570619 or NCT03333616 Patients with advance prostate cancer , including Castration-resistant (CRPC) Received an IV infusion of two drugs that boost the immune system:
ipilimumab
www.winknews.com/2018/12/06/checkmate-for-prostate-cancer/ The clinical trial , may be one these NCT02601014 , NCT03532217 , NCT02985957 , NCT03570619 or NCT03333616 Patients with advance prostate cancer , including Castration-resistant (CRPC) Received an IV infusion of two drugs that boost the immune system:
ipilimumab
bboby
in
Advanced Prostate Cancer
6 years ago
Jim Allison, Nobel Prize, Ipilimumab, etc.
term=
ipilimumab
+AND+Bristol+AND+prostate&rank=3 -Patrick
term=
ipilimumab
+AND+Bristol+AND+prostate&rank=3 -Patrick
pjoshea13
in
Advanced Prostate Cancer
6 years ago
My Story of Stage IV Kidney Cancer
Nivolumab and
Ipilimumab
. After Surgery and before the start of my clinical trial I did a ct-scan. Dated 05/26/2017 revealed MULTIPLES nodes in the lungs (covered) 3.8 cm and 3.4 cm the largest. My symptoms started to come back. Unable to recover weight...
Nivolumab and
Ipilimumab
. After Surgery and before the start of my clinical trial I did a ct-scan. Dated 05/26/2017 revealed MULTIPLES nodes in the lungs (covered) 3.8 cm and 3.4 cm the largest. My symptoms started to come back. Unable to recover weight...
mvrace4ever
in
Kidney Cancer Support
6 years ago
Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer.
Ipilimumab
plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer.
Ipilimumab
plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Long-term complete remission with ipilimumab in metastatic castrate-resistant prostate cancer: case report of two patients
: Case presentation Here, we report on two patients who received
ipilimumab
in these trials and are still in long-term complete remission with a follow-up of 64 and 52 months respectively after the initiation of
ipilimumab
.
: Case presentation Here, we report on two patients who received
ipilimumab
in these trials and are still in long-term complete remission with a follow-up of 64 and 52 months respectively after the initiation of
ipilimumab
.
JLS1
in
Advanced Prostate Cancer
6 years ago
Immunotherapy for Prostate Cancer: Where Do We Go From Here?—PART 1: Prostate Cancer Vaccines
This trial demonstrated no significant increase in adverse events with the combination compared with
ipilimumab
alone,[29] with 14/24 chemotherapy-naive patients (58%) experiencing PSA decline, and with 6/24 having declines of > 50%; moreover, the median OS in this trial was a robust 31.6 months.[30]
This trial demonstrated no significant increase in adverse events with the combination compared with
ipilimumab
alone,[29] with 14/24 chemotherapy-naive patients (58%) experiencing PSA decline, and with 6/24 having declines of > 50%; moreover, the median OS in this trial was a robust 31.6 months.[30]
JLS1
in
Advanced Prostate Cancer
6 years ago
re: liver and lung mets....."Ipilimumab with radiation may slow late-stage cancer tumor growth" - Sept 25, 2017
I didn't see anyone post this, so I thought I'd share:
Ipilimumab
with radiation may slow late-stage cancer tumor growth September 25, 2017 https://www.healio.com/hematology-oncology/prostate-cancer/news/online/%7B563b4bf3-bbd7-43d1-ac9b-c699d0af847f%7D/
ipilimumab
-with-radiation-may-slow-late-stage-cancer-tumor-growth
I didn't see anyone post this, so I thought I'd share:
Ipilimumab
with radiation may slow late-stage cancer tumor growth September 25, 2017 https://www.healio.com/hematology-oncology/prostate-cancer/news/online/%7B563b4bf3-bbd7-43d1-ac9b-c699d0af847f%7D/
ipilimumab
-with-radiation-may-slow-late-stage-cancer-tumor-growth
JLS1
in
Advanced Prostate Cancer
7 years ago
New to cancer, New to site
I find out in the next 2 weeks if I will continue with just the current regimen, or add chemo (cabazitaxel and carboplatin) or immunotherapy (
ipilimumab
). I am blessed that I do not have any pain and am able to continue working. I also have a very supportive family.
I find out in the next 2 weeks if I will continue with just the current regimen, or add chemo (cabazitaxel and carboplatin) or immunotherapy (
ipilimumab
). I am blessed that I do not have any pain and am able to continue working. I also have a very supportive family.
Sixfactorformula
in
Advanced Prostate Cancer
6 years ago
Intro and Immunotherapy question
A trial is available which adds Yervoy (
Ipilimumab
) after the Provenge. If anyone has experience with this I would love to hear about it. The Signet Ring Cell type I have is rare and considered very aggressive. If there is someone out there with the same type please let me know your experience.
A trial is available which adds Yervoy (
Ipilimumab
) after the Provenge. If anyone has experience with this I would love to hear about it. The Signet Ring Cell type I have is rare and considered very aggressive. If there is someone out there with the same type please let me know your experience.
mlengle
in
Advanced Prostate Cancer
7 years ago
First recurrence and immunotherapy being offered!
The drugs are Nivolumab and
Ipilimumab
(if you google them together, the trial comes up). Your thoughts?????? Wishing you wonderful ladies a good weekend! Fingers crossed for many of us that good results are to be had with this! MaxJor
The drugs are Nivolumab and
Ipilimumab
(if you google them together, the trial comes up). Your thoughts?????? Wishing you wonderful ladies a good weekend! Fingers crossed for many of us that good results are to be had with this! MaxJor
Maxjor
in
My Ovacome
7 years ago
Immuno-therapy Nivolumab & Ipilimumab - update
Clinical Trials.gov An Investigational Immuno-therapy Study for Safety of Nivolumab in Combination With
Ipilimumab
to Treat Advanced Cancers We are in Newcastle upon Tyne and the page still says 'not recruiting yet, so it must be very new to the North East. Hope it helps someone else.
Clinical Trials.gov An Investigational Immuno-therapy Study for Safety of Nivolumab in Combination With
Ipilimumab
to Treat Advanced Cancers We are in Newcastle upon Tyne and the page still says 'not recruiting yet, so it must be very new to the North East. Hope it helps someone else.
Julesgettingthere
in
The Roy Castle Lung Cancer Foundation
7 years ago
nivolumab plus ipilimumab compared to pembrolizumab
ICER for nivolumab plus
ipilimumab
compared to pembrolizumab is likely to be less than £30,000 per QALY gained in the mixed population of BRAF mutation-positive and mutation-negative advanced melanoma when the patient access scheme prices were used in the model.
ICER for nivolumab plus
ipilimumab
compared to pembrolizumab is likely to be less than £30,000 per QALY gained in the mixed population of BRAF mutation-positive and mutation-negative advanced melanoma when the patient access scheme prices were used in the model.
Julesgettingthere
in
The Roy Castle Lung Cancer Foundation
7 years ago
Running out of treatment options? Thoughts?
I am looking into a clinical trial at MD Anderson -
Ipilimumab
and Nivolumab combination .My current oncologist at Sloan ( Susan Slovin) does not think the current immunotherapy on the markets (provenge ) would be effective for me.
I am looking into a clinical trial at MD Anderson -
Ipilimumab
and Nivolumab combination .My current oncologist at Sloan ( Susan Slovin) does not think the current immunotherapy on the markets (provenge ) would be effective for me.
Bceagle
in
Advanced Prostate Cancer
7 years ago
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