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Ibrutinib
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A good story of hope when diagnosed with CLL
Various treatments were used over the years and now she is on
ibrutinib
and has a busy life playing golf and travelling to her native Germany. The story is from the MD Anderson web pages, a hospital with an impressive record of treating CLL.
Various treatments were used over the years and now she is on
ibrutinib
and has a busy life playing golf and travelling to her native Germany. The story is from the MD Anderson web pages, a hospital with an impressive record of treating CLL.
Kwenda
in
CLL Support
10 years ago
FCR Round One Down - 5 to go....
Also - I want to make the point that I think my insistence on trying to hang on for the
ibrutinib
trial put me very close to missing the optimum window of opportunity for treatment of any kind.
Also - I want to make the point that I think my insistence on trying to hang on for the
ibrutinib
trial put me very close to missing the optimum window of opportunity for treatment of any kind.
jibs60
in
CLL Support
10 years ago
Ibrutinib Slow but steady foreward movement.
Ibrutinib
is being developed by Janssen with Pharmacyclics, Inc. for the treatment of several forms of blood cancer. If approved,
ibrutinib
will be the first commercially available therapy targeting BTK.
Ibrutinib
is being developed by Janssen with Pharmacyclics, Inc. for the treatment of several forms of blood cancer. If approved,
ibrutinib
will be the first commercially available therapy targeting BTK.
Kwenda
in
CLL Support
11 years ago
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6 weeks on Ibrutinib and I am having slight periodic chest pains and shortness of breath .... many time a day...
I attribute it to the fatigue that is a side effect. After speaking to a retired MD friend of mine he advised me to write to everyone to see if this is the same type of reaction they get from this product ? He also advised a almost immediate visit to my Cardiologist. Will see the cardiologist
I attribute it to the fatigue that is a side effect. After speaking to a retired MD friend of mine he advised me to write to everyone to see if this is the same type of reaction they get from this product ? He also advised a almost immediate visit to my Cardiologist. Will see the cardiologist
fish61
in
CLL Support
10 years ago
Ibrutinib Trial
I've just discovered this forum trying to find out some information about the drug
Ibrutinib
and it was great to read all the posts. I have been on W & W for about four years and I've just been told that chemo is now necessary.
I've just discovered this forum trying to find out some information about the drug
Ibrutinib
and it was great to read all the posts. I have been on W & W for about four years and I've just been told that chemo is now necessary.
Medwaylady
in
CLL Support
11 years ago
Update on Novel B-Cell Receptor Signaling Inhibitors from NCCN 8th Annual Congress on Hematologic Malignancies
Brief mention is also made of the benefits observed when using
Ibrutinib
with Ofatumumab (Arzerra) and rituximab.
Brief mention is also made of the benefits observed when using
Ibrutinib
with Ofatumumab (Arzerra) and rituximab.
AussieNeil
Administrator
in
CLL Support
11 years ago
ASH 2013 - Dr Sharman's abstracts
The B cell receptor signaling pathway involves a sequence of enzymes that start with Syk (fostamatanib, GS-9973), goes to BTK (
ibrutinib
and CC-292), then on to PI3K (idelalisib). Antibody drug conjugates are another favorite topic of mine.
The B cell receptor signaling pathway involves a sequence of enzymes that start with Syk (fostamatanib, GS-9973), goes to BTK (
ibrutinib
and CC-292), then on to PI3K (idelalisib). Antibody drug conjugates are another favorite topic of mine.
AussieNeil
Administrator
in
CLL Support
10 years ago
Making Peace with FCR in the Squeezed Middle: Response to another very hopeful video from Steven Rosen
I do not mean in any way to undermine the very real hope and excitement we all feel for the future, nor to dampen the spirits of those lucky enough to be involved in
ibrutinib
trials now or in the very near future.
I do not mean in any way to undermine the very real hope and excitement we all feel for the future, nor to dampen the spirits of those lucky enough to be involved in
ibrutinib
trials now or in the very near future.
jibs60
in
CLL Support
11 years ago
on Ibrutinib for less than 2 weeks and lymph node in my neck have gone from silver $ size and about 3/8 inch thick toa little larger
MD Anderson has a clinical trial going on now , randomized , open testing Chlorambucil and
Ibrutinib
... I got the
Ibrutinib
.... only thing is the bone marrow test (8 days ago ) still hurts like hell. Good luck fish61
MD Anderson has a clinical trial going on now , randomized , open testing Chlorambucil and
Ibrutinib
... I got the
Ibrutinib
.... only thing is the bone marrow test (8 days ago ) still hurts like hell. Good luck fish61
fish61
in
CLL Support
11 years ago
Dr Sharman's thoughts on the race for FDA Approval for Obinituzumab, Ibrutinib and Idelalisib
Following Gilead's announcement regarding Idelalisib: https://healthunlocked.com/cllsupport/posts/130204565/gilead-to-stop-phase-3-study-116-of-idelalisib-in-chronic-lymphocytic-leukemia-early-because-of-positive-risk-benefit Dr Sharman summarises where things stand with Obinituzumab,
Ibrutinib
and Idelalisib
Following Gilead's announcement regarding Idelalisib: https://healthunlocked.com/cllsupport/posts/130204565/gilead-to-stop-phase-3-study-116-of-idelalisib-in-chronic-lymphocytic-leukemia-early-because-of-positive-risk-benefit Dr Sharman summarises where things stand with Obinituzumab,
Ibrutinib
and Idelalisib
AussieNeil
Administrator
in
CLL Support
11 years ago
iwCLL 2013: Dr. Jan Burger on the Role of the Micro-Environment in CLL
While this is basic bench science, it is critical to understanding how many of the novel therapies such as idelalisib and
ibrutinib
work and how difficult it can be for traditional therapies to get rid of CLL deep in the nodes and marrow.
While this is basic bench science, it is critical to understanding how many of the novel therapies such as idelalisib and
ibrutinib
work and how difficult it can be for traditional therapies to get rid of CLL deep in the nodes and marrow.
bkoffman
CLL CURE Hero
in
CLL Support
11 years ago
Anyone know if CLL 10 trial (FCR v Ibrutinib+R) is open for recruitment anywhere in UK?
Mikey - I know you are on the trial, and you said recently that you thought it would be full by Christmas - can you tell me where you got that information please...I think I need to move very quickly, if it's not too late already to get a shot at the
ibrutinib
arm ...I've edited this post though because
Mikey - I know you are on the trial, and you said recently that you thought it would be full by Christmas - can you tell me where you got that information please...I think I need to move very quickly, if it's not too late already to get a shot at the
ibrutinib
arm ...I've edited this post though because
jibs60
in
CLL Support
11 years ago
Dr Rick Furman interviewed at IWCLL by Patient Power
Furman explains how a leading treatment candidate,
ibrutinib
, works.
[i]He also discusses whether there is concern that some patients may develop resistance to the drug and its effectiveness.
Furman explains how a leading treatment candidate,
ibrutinib
, works.
[i]He also discusses whether there is concern that some patients may develop resistance to the drug and its effectiveness.
AussieNeil
Administrator
in
CLL Support
11 years ago
ABT-199 Trial experience in Australia
When I asked Andrew whether ABT-199 could help patients with Richter's Transformation, he responded that like
Ibrutinib
, it wouldn't work as a single therapy and in fact it had mostly stopped working when Richter's developed.
When I asked Andrew whether ABT-199 could help patients with Richter's Transformation, he responded that like
Ibrutinib
, it wouldn't work as a single therapy and in fact it had mostly stopped working when Richter's developed.
AussieNeil
Administrator
in
CLL Support
11 years ago
New Drug Application Filing for Ibrutinib Accepted in Two B-cell Malignancies by the U.S. FDA
This is NOT an approval,
it is the beginning of the approval process but only for two uses or indications... previously treated mantle cell lymphoma (MCL) and previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). http://online.wsj.com/article/PR-CO-20130829
This is NOT an approval,
it is the beginning of the approval process but only for two uses or indications... previously treated mantle cell lymphoma (MCL) and previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). http://online.wsj.com/article/PR-CO-20130829
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
I was about to start a course of Ibrutinib as a treatment naive patient and was told that I must wait until my anaemia was under control.
I have been told I must have two pints of blood transfused and a course of steroids, does anyone have any knowledge/experience of AIHA which is the possible cause of this fatigue/anaemia with a haemoglobin count of eight and no other symptoms since diagnosis eight years ago?
I have been told I must have two pints of blood transfused and a course of steroids, does anyone have any knowledge/experience of AIHA which is the possible cause of this fatigue/anaemia with a haemoglobin count of eight and no other symptoms since diagnosis eight years ago?
Berrytog
in
CLL Support
11 years ago
FDA application made for Ibrutinib in refractory/relapsed CLL/SLL ONLY
Janssen Research & Development, LLC announced the submission of a New Drug Application for
ibrutinib
to the U.S.
Janssen Research & Development, LLC announced the submission of a New Drug Application for
ibrutinib
to the U.S.
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Ibrutinib article includes info on leukaemia and lymphoma and how lymphocytes function
Interesting Gizmag article on
Ibrutinib
with some good background on how lymphocytes work and how CLL and MCL differ. (
Ibrutinib
trials were done on both). http://www.gizmag.com/lymphoma-treatment-cancer-
ibrutinib
/28085/ It is worth looking through the associated pictures.
Interesting Gizmag article on
Ibrutinib
with some good background on how lymphocytes work and how CLL and MCL differ. (
Ibrutinib
trials were done on both). http://www.gizmag.com/lymphoma-treatment-cancer-
ibrutinib
/28085/ It is worth looking through the associated pictures.
AussieNeil
Administrator
in
CLL Support
11 years ago
A Mechanism-Driven Treatment for Chronic Lymphocytic Leukemia?
Editorial http://www.nejm.org/doi/pdf/10.1056/NEJMe1303054 Also published data on early
ibrutinib
trial...
Editorial http://www.nejm.org/doi/pdf/10.1056/NEJMe1303054 Also published data on early
ibrutinib
trial...
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Vkakoi strane v Evrope proischodet kliniceskije ispytanije s IBRUTINIB ( CLL 17p deletion)
Uncluding chronic lymphocystis leukomija 17 p deletion (CLL)
Uncluding chronic lymphocystis leukomija 17 p deletion (CLL)
deimante
in
CLL Support
11 years ago
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