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Enzalutamide
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Quality of Life in Second-Line Treatment of Metastatic Castration-Resistant Prostate
At the time of study,
Enzalutamide
was not yet licensed in Switzerland so not included. It's a very interesting article so thought I would share it. http://www.clinical-genitourinary-cancer.com/article/S1558-7673(17)30244-6/pdf
At the time of study,
Enzalutamide
was not yet licensed in Switzerland so not included. It's a very interesting article so thought I would share it. http://www.clinical-genitourinary-cancer.com/article/S1558-7673(17)30244-6/pdf
Hidden
in
Advanced Prostate Cancer
6 years ago
Is AR-V7 Testing Pointless?
Neither abiraterone nor
enzalutamide
can have therapeutic activity against AR-V7 cells.
Neither abiraterone nor
enzalutamide
can have therapeutic activity against AR-V7 cells.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
No longer prostate cancer
This explains why I failed to get benefit from Provenge or
Enzalutamide
. The rapid change occurred since August when a PET scan showed the growth of tumors in my mediastinum and left pleural space. They have now become very aggressive and are producing fluid rapidly.
This explains why I failed to get benefit from Provenge or
Enzalutamide
. The rapid change occurred since August when a PET scan showed the growth of tumors in my mediastinum and left pleural space. They have now become very aggressive and are producing fluid rapidly.
DenDoc
in
Advanced Prostate Cancer
6 years ago
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Ralaniten [EPI-506]
mentions Ralaniten (aka EPI-506) as a: "novel first-in-class drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone,
enzalutamide
mentions Ralaniten (aka EPI-506) as a: "novel first-in-class drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone,
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Phase II study of enzalutamide monotherapy with radiation therapy for intermediate risk PCa)
Testosterone and free testosterone levels rose significantly on
enzalutamide
therapy. Conclusions:
Enzalutamide
monotherapy with RT may be as effective as castrating ADT, and associated with fewer side effects.
Testosterone and free testosterone levels rose significantly on
enzalutamide
therapy. Conclusions:
Enzalutamide
monotherapy with RT may be as effective as castrating ADT, and associated with fewer side effects.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Finally, Real Promise' for Prostate Cancers With No Therapy20+-Month Improvement in Metastasis-Free Survival
In the PROSPER study, eligible men were also randomly assigned in a 2:1 ratio to receive either
enzalutamide
160 mg or placebo.
In the PROSPER study, eligible men were also randomly assigned in a 2:1 ratio to receive either
enzalutamide
160 mg or placebo.
Hidden
in
Advanced Prostate Cancer
6 years ago
Recent article about Lutetium 177 treatment in advanced mCRPC by doctors at the Technical University of Munich
Eligibility criteria for 177Lu-PSMA-I&T therapy included previous treatment with abiraterone or
enzalutamide
, previous taxane-based chemotherapy or unsuitability for taxanes as well as positive 68Ga-PSMA tracer uptake of metastases in a prior PET-scan.
Eligibility criteria for 177Lu-PSMA-I&T therapy included previous treatment with abiraterone or
enzalutamide
, previous taxane-based chemotherapy or unsuitability for taxanes as well as positive 68Ga-PSMA tracer uptake of metastases in a prior PET-scan.
Hidden
in
Advanced Prostate Cancer
6 years ago
Apalutamide - SPARTAN versus Enzalutamide - PROSPER.
term=
Enzalutamide
+PROSPER&rank=1 [4] https://www.clinicaltrials.gov/ct2/show/NCT01946204?term=Apalutamide+SPARTAN&rank=1
term=
Enzalutamide
+PROSPER&rank=1 [4] https://www.clinicaltrials.gov/ct2/show/NCT01946204?term=Apalutamide+SPARTAN&rank=1
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Interesting result for BRCA patients from ASCO2018
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic castration-resistant prostate cancer receiving first-line abiraterone and
enzalutamide
."
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic castration-resistant prostate cancer receiving first-line abiraterone and
enzalutamide
."
snoraste
in
Advanced Prostate Cancer
6 years ago
New Memberas
Currently on
Enzalutamide
with fingers crossed!
Currently on
Enzalutamide
with fingers crossed!
PeturB
in
Advanced Prostate Cancer
6 years ago
Advanced metastatic protate cancer but still hoping.
Plus daily intake of
enzalutamide
. I have been on other medications but they have failed my PSA started to rise and then I've tried a new drug which put it back down again at the moment
enzalutamide
appears to be the best one so far for me.
Plus daily intake of
enzalutamide
. I have been on other medications but they have failed my PSA started to rise and then I've tried a new drug which put it back down again at the moment
enzalutamide
appears to be the best one so far for me.
GarawayGhd
in
Advanced Prostate Cancer
6 years ago
Is anyone else on the Enzalutamide and LY3023414 clinical trial?
My husband has been on the xtandi phase 2 trial a short time and his PSA is dropping. It went from 21 to 3 in ten days. So far, so good. The fatigue and bone pain have increased. It is not stopping my husband though. I am looking to compare notes with someone else on the trial Thank you to all the
My husband has been on the xtandi phase 2 trial a short time and his PSA is dropping. It went from 21 to 3 in ten days. So far, so good. The fatigue and bone pain have increased. It is not stopping my husband though. I am looking to compare notes with someone else on the trial Thank you to all the
StephjoeSteph4197
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium [PROSPER].
Abstract: https://gucasym.org/sites/gucasym.org/files/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of
enzalutamide
Abstract: https://gucasym.org/sites/gucasym.org/files/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
Prior treatment with
enzalutamide
and/or abiraterone is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
Prior treatment with
enzalutamide
and/or abiraterone is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Bipolar Androgen Therapy in Men With Metastatic Castration-Resistant Prostate Cancer After Progression on Enzalutamide
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-castration-resistant-prostate-cancer-after-progression-on-
enzalutamide
/62093/61/11/1
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-castration-resistant-prostate-cancer-after-progression-on-
enzalutamide
/62093/61/11/1
snoraste
in
Advanced Prostate Cancer
6 years ago
AR-V7, Zytiga(abiraterone) and Xtandi (enzalutamide)
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
Cmdrdata
in
Advanced Prostate Cancer
6 years ago
Metformin reverses prostate cancer resistance to enzalutamide?
Judge for yourself.. https://www.ncbi.nlm.nih.gov/pubmed/28837141 Of course what do I know?
Judge for yourself.. https://www.ncbi.nlm.nih.gov/pubmed/28837141 Of course what do I know?
Hidden
in
Advanced Prostate Cancer
6 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
If these DNA repair alterations are present after treatment with abiraterone, docetaxel, or
enzalutamide
, there is a higher response rate to olaparib.
If these DNA repair alterations are present after treatment with abiraterone, docetaxel, or
enzalutamide
, there is a higher response rate to olaparib.
JLS1
in
Advanced Prostate Cancer
6 years ago
FDA Grants Priority Review to Apalutamide ...
Apalutamide may be the successor to
Enzalutamide
[Xtandi].
Apalutamide may be the successor to
Enzalutamide
[Xtandi].
pjoshea13
in
Advanced Prostate Cancer
6 years ago
thoughts from a newby
First line hormone therapy (ADT) injection degarelix Firmagon, another ADT docetaxel Taxotere, chemotherapy now given alongside ADT abiraterone Zytiga
enzalutamide
Extandi, Xtandi Prednisone or Prednisolone, corticosteroid (type of steroid) to treat/avoid allergies Ra 223 dichoride Xofigo
First line hormone therapy (ADT) injection degarelix Firmagon, another ADT docetaxel Taxotere, chemotherapy now given alongside ADT abiraterone Zytiga
enzalutamide
Extandi, Xtandi Prednisone or Prednisolone, corticosteroid (type of steroid) to treat/avoid allergies Ra 223 dichoride Xofigo
rpol
in
Advanced Prostate Cancer
6 years ago
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