Experiences with

Eculizumab

My son has had Eculizumab and Rituximab with no success and is now declining rapidly with kidney function.

When were you diagnosed, did you have a battle to get your local healthboard to ok Eculizumab treatment?.

Dear experts, my son has DDD and have been treated with Soliris since January. He feels much better, his sC5b-9 value has gone down from 560 to 319 within 2.5 months, although the C3 value has dropped from 27 mg/dl to 18, but proteinuria and haematuria are almost away. So, obviously, Soliris is good

., eculizumab) therapies may be considered based on data from case reports. REFERENCE: Tektonidou M, Andreoli L, Limper M, et al. “EULAR recommendations for the management of antiphospholipid syndrome in adults," Annals of Rheumatic Diseases (2019), DOI: 10.1136/annrheumdis-2019-215213.

., eculizumab) therapies may be considered based on data from case reports. REFERENCE: Tektonidou M, Andreoli L, Limper M, et al. “EULAR recommendations for the management of antiphospholipid syndrome in adults," Annals of Rheumatic Diseases (2019), DOI: 10.1136/annrheumdis-2019-215213.

Eculizumab is another drug known as a monoclonal antibody. This drug can specifically target the complement system and has been used to treat C3G. Treating conditions that sometimes occur with C3G C3G damages the kidneys. After the kidneys, the eye is most often damaged.

Since some patients with C3G have shown improvement with eculizumab, it is hoped that avacopan, while administered by mouth rather than infusion, can produce the desired therapeutic effect without the side effects involved with eculizumab and reduced levels of MAC .

Although I had reached stage 4 kidney failure at one time, I am currently on eculizumab and my native kidneys are doing well at stage 2. I have been on this treatment for a little more than two years. My C3GN is believed to be caused by a mutation in C3 that has not been documented before.