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Dyskinesia
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Aspen Neuroscience Granted Fast Track Designation
Patients can experience non-motor symptoms such as mental and behavioral changes, sleep problems, depression, memory difficulties and fatigue; and motor symptoms caused by the loss of dopamine neurons in the brain, including unintended or uncontrollable movements (
dyskinesia
), shaking (tremor), stiffness
Patients can experience non-motor symptoms such as mental and behavioral changes, sleep problems, depression, memory difficulties and fatigue; and motor symptoms caused by the loss of dopamine neurons in the brain, including unintended or uncontrollable movements (
dyskinesia
), shaking (tremor), stiffness
redhawk1
in
Cure Parkinson's
6 months ago
amantadine, and Lipo atrophy
has anyone taking amantadine experienced lLipo atrophy? All of my fat has disappeared, and my buttocks is flaccid. I read that early antiretrovirals could caus Lipo atrophy, and I wonder if amantadine could be doing the same.
has anyone taking amantadine experienced lLipo atrophy? All of my fat has disappeared, and my buttocks is flaccid. I read that early antiretrovirals could caus Lipo atrophy, and I wonder if amantadine could be doing the same.
Marcia123
in
Cure Parkinson's
1 year ago
Effects from going off of amantadine
I am taking 2 tablets 25-100 C/L 4x per day and 1 tablet of 50-200 at bedtime. Back in August of this year doctor put me on amantadine starting with 2.5 ml. I was supposed to eventually get to 10 ml, but I never got past 7.5 because of the nausea. It seemed to help a little but I still continued to have
I am taking 2 tablets 25-100 C/L 4x per day and 1 tablet of 50-200 at bedtime. Back in August of this year doctor put me on amantadine starting with 2.5 ml. I was supposed to eventually get to 10 ml, but I never got past 7.5 because of the nausea. It seemed to help a little but I still continued to have
mleec
in
Cure Parkinson's
1 year ago
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Fast acting Levodopa?
I recall that somebody had written about making a quick acting levodopa by grinding up a tab of Sinemet or dissolving it in carbonated water or.... ? My memory is bad on this because I had no need for it at the time. My understanding is that levodopa needs to reach and be absorbed in the small intestine
I recall that somebody had written about making a quick acting levodopa by grinding up a tab of Sinemet or dissolving it in carbonated water or.... ? My memory is bad on this because I had no need for it at the time. My understanding is that levodopa needs to reach and be absorbed in the small intestine
Zardoz
in
Cure Parkinson's
1 year ago
Vibration Plate Therapy
(Canada) As my husband has signs of Parkinsons and wishes to address this issue naturally I recently received a vibrating plate. Note: Due to knee problems his physical activity is limited. I am impressed with the EILISON FitMax KM-818. There are a variety of exercises and settings benefiting improved
(Canada) As my husband has signs of Parkinsons and wishes to address this issue naturally I recently received a vibrating plate. Note: Due to knee problems his physical activity is limited. I am impressed with the EILISON FitMax KM-818. There are a variety of exercises and settings benefiting improved
PD10123
in
Cure Parkinson's
1 year ago
Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease
CONCLUSIONS Unilateral pallidal ultrasound ablation resulted in a higher percentage of patients who had improved motor function or reduced
dyskinesia
than a sham procedure over a period of 3 months but was associated with adverse events.
CONCLUSIONS Unilateral pallidal ultrasound ablation resulted in a higher percentage of patients who had improved motor function or reduced
dyskinesia
than a sham procedure over a period of 3 months but was associated with adverse events.
Hidden
in
Cure Parkinson's
1 year ago
weight loss
She does not have tremor but quite a bit of
dyskinesia
. Been referred for gastrointestinal and blood tests. Anyone have any suggestions?
She does not have tremor but quite a bit of
dyskinesia
. Been referred for gastrointestinal and blood tests. Anyone have any suggestions?
MadgeB
in
Cure Parkinson's
1 year ago
Meds on empty stomach
Does anyone suffer with stomach pains and or diarrhea when taking meds on an empty stomach? I take amantadine and sinemet and selegine?? Thanks
Does anyone suffer with stomach pains and or diarrhea when taking meds on an empty stomach? I take amantadine and sinemet and selegine?? Thanks
Hoffman123
in
Cure Parkinson's
1 year ago
video: Low-dose ketamine produces long-term reduction in levodopa-induced dyskinesia
https://youtu.be/4sygods1Txk Preclinical data has previously suggested that low-dose ketamine treatment has short-term antiparkinsonian activity and can reduce levodopa-induced
dyskinesia
in the long term after an initial 10-hour total treatment.
https://youtu.be/4sygods1Txk Preclinical data has previously suggested that low-dose ketamine treatment has short-term antiparkinsonian activity and can reduce levodopa-induced
dyskinesia
in the long term after an initial 10-hour total treatment.
Hidden
in
Cure Parkinson's
2 years ago
Cystatin C and dyskinesia
Serum Cys C levels were independently associated with
dyskinesia
and may be a valuable screening tool for differentiating
dyskinesia
in PD patients. https://pubmed.ncbi.nlm.nih.gov/31054924/
Serum Cys C levels were independently associated with
dyskinesia
and may be a valuable screening tool for differentiating
dyskinesia
in PD patients. https://pubmed.ncbi.nlm.nih.gov/31054924/
House2
in
Cure Parkinson's
2 years ago
Ketamine?
Dyskinesia
decreased 51% during ketamine administration, 49% at three weeks after treatment, and 41% at three months. This effect was measured by the Unified
Dyskinesia
Rating Scale (UDysRS), a scale developed to evaluate involuntary movements.
Dyskinesia
decreased 51% during ketamine administration, 49% at three weeks after treatment, and 41% at three months. This effect was measured by the Unified
Dyskinesia
Rating Scale (UDysRS), a scale developed to evaluate involuntary movements.
kaypeeoh
in
Cure Parkinson's
2 years ago
sudden increase in dyskinesia
Then in one day,
dyskinesia
all day. Would be very grateful for any words of wisdom.
Then in one day,
dyskinesia
all day. Would be very grateful for any words of wisdom.
Maple-st-tig
in
Cure Parkinson's
2 years ago
PharmaTher Submits FDA Meeting Package to Discuss Phase 3 Program and Fast Track Designation for KETARX™ (Ketamine) in PD
Food and Drug Administration ("FDA") to discuss advancing KETARX™ (racemic ketamine) into Phase 3 development as a treatment for levodopa-induced
dyskinesia
in Parkinson's disease ("LID-PD").
Food and Drug Administration ("FDA") to discuss advancing KETARX™ (racemic ketamine) into Phase 3 development as a treatment for levodopa-induced
dyskinesia
in Parkinson's disease ("LID-PD").
Hidden
in
Cure Parkinson's
1 year ago
no tremor
day one cracking headache then realised my tremor was gone - day 2 had a great massage still no tremor or
dyskinesia
. It’s not stress free- teenagers arnt!!! Day 4 a little coming back (was quite bad before I left home. Swimming a bit and doing lots of stressful water slides.
day one cracking headache then realised my tremor was gone - day 2 had a great massage still no tremor or
dyskinesia
. It’s not stress free- teenagers arnt!!! Day 4 a little coming back (was quite bad before I left home. Swimming a bit and doing lots of stressful water slides.
Annieartist
in
Cure Parkinson's
2 years ago
Phase 3 results, AbbVie, foslevodopa-foscarbidopa, Improves motor fluctuations
Interpretation
Foslevodopa-foscarbidopa improved motor fluctuations, with benefits in both on time without troublesome
and off time.
Interpretation
Foslevodopa-foscarbidopa improved motor fluctuations, with benefits in both on time without troublesome
and off time.
Hidden
in
Cure Parkinson's
1 year ago
Medication for PSP
I would like to discuss with anyone else who has my symptoms and is taking my medication. Carbidopa and Levodopa and Amantadine
I would like to discuss with anyone else who has my symptoms and is taking my medication. Carbidopa and Levodopa and Amantadine
Zarzuela
in
PSP Association
2 years ago
New Phase 3 Trial Data Back P2B001 as Therapy for Early Parkinson’s
P2B001 is an extended-release or ER formulation, meaning that the medication is formulated so that it is released slowly over time. It contains low doses of pramipexole (0.6 mg) and rasagiline (0.75 mg). Both compounds are approved therapies for Parkinson’s — marketed as Mirapex (pramipexole) and Azilect
P2B001 is an extended-release or ER formulation, meaning that the medication is formulated so that it is released slowly over time. It contains low doses of pramipexole (0.6 mg) and rasagiline (0.75 mg). Both compounds are approved therapies for Parkinson’s — marketed as Mirapex (pramipexole) and Azilect
Farooqji
in
Cure Parkinson's
2 years ago
Vitamin B makes dyskinesia worse?
While I see improvements in my movements, I also found my
dyskinesia
is much worse. Does anyone have similar experience? Thanks, Laura
While I see improvements in my movements, I also found my
dyskinesia
is much worse. Does anyone have similar experience? Thanks, Laura
LauraYu
in
Cure Parkinson's
2 years ago
Parkinson’s Community website
I must have signed up for the information on a “bad” day (i don’t remember signing up) because i received a call from a very nice man yesterday who spent an hour reviewing my situation and suggested i might look into Gocovri or Apokyn for off times and mild
dyskinesia
…and that he would pass this on to
I must have signed up for the information on a “bad” day (i don’t remember signing up) because i received a call from a very nice man yesterday who spent an hour reviewing my situation and suggested i might look into Gocovri or Apokyn for off times and mild
dyskinesia
…and that he would pass this on to
rebtar
in
Cure Parkinson's
1 year ago
Phase 2 Clinical Trial of DopaFuse Delivery System
The DopaFuse Delivery System is a patented, intra-oral system that continuously and noninvasively delivers levodopa and carbidopa at a controlled rate for patients with PD. The DopaFuse System consists of an oral retainer, its case, and a prefilled, single-use drug container that continuously releases
The DopaFuse Delivery System is a patented, intra-oral system that continuously and noninvasively delivers levodopa and carbidopa at a controlled rate for patients with PD. The DopaFuse System consists of an oral retainer, its case, and a prefilled, single-use drug container that continuously releases
Farooqji
in
Cure Parkinson's
2 years ago
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