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Docetaxel
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At the time of my profile creation, I was receiving Lupron shots every three months and in the middle 6 cycles of Chemotherapy (
docetaxel
i.e., Taxotere). The chemo treatment ended in March 2017 with full expectation to follow it up with radiation treatments.
At the time of my profile creation, I was receiving Lupron shots every three months and in the middle 6 cycles of Chemotherapy (
docetaxel
i.e., Taxotere). The chemo treatment ended in March 2017 with full expectation to follow it up with radiation treatments.
grahaminator63
in
Advanced Prostate Cancer
6 years ago
What is meant when told that a met has been "resolved" after a mid-chemo CT scan?
Last fall, however, my PSA had risen to 16.8, and I commenced combined hormone therapy (Lupron) and chemotherapy (
docetaxel
) in late December 2017.
Last fall, however, my PSA had risen to 16.8, and I commenced combined hormone therapy (Lupron) and chemotherapy (
docetaxel
) in late December 2017.
wcochranbond
in
Advanced Prostate Cancer
6 years ago
Chronic?
I went the
Docetaxel
route to start the show. Currently the buzz is starting the show with Zytiga. You would think that the world of oncology developed something new. Ha! They simply shuffled the deck. I know soon I will be swallowing Zytiga pills and when that stops being effective, on to Xtandi.
I went the
Docetaxel
route to start the show. Currently the buzz is starting the show with Zytiga. You would think that the world of oncology developed something new. Ha! They simply shuffled the deck. I know soon I will be swallowing Zytiga pills and when that stops being effective, on to Xtandi.
Hidden
in
Advanced Prostate Cancer
6 years ago
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Need to decide path forward... which way to go?
Discussed the additional recommendation of adding Zytiga/prednisone (STAMPEDE) or
docetaxel
(also STAMPEDE) to hormonal therapy in node positive disease setting; overall survival benefit is noted.
Discussed the additional recommendation of adding Zytiga/prednisone (STAMPEDE) or
docetaxel
(also STAMPEDE) to hormonal therapy in node positive disease setting; overall survival benefit is noted.
AuburnAngel
in
Advanced Prostate Cancer
6 years ago
Second opinion update
Treatment is Firmagon and Xgeva 1x / 4 wks, casodex daily, prednisone 5 mg 2x / day, and
docetaxel
every 3 wks. PSA is down to 0.14. Had my fifth of 6
docetaxel
infusions today. Second opinion doctor is at a teaching hospital and he specializes in prostate, bladder and testicular cancers.
Treatment is Firmagon and Xgeva 1x / 4 wks, casodex daily, prednisone 5 mg 2x / day, and
docetaxel
every 3 wks. PSA is down to 0.14. Had my fifth of 6
docetaxel
infusions today. Second opinion doctor is at a teaching hospital and he specializes in prostate, bladder and testicular cancers.
Canoehead
in
Advanced Prostate Cancer
6 years ago
Chemotherapy and air travel and risk of clots
I have been advised about the risk of clots forming during air travel and in particular while undergoing chemotherapy (I have completed 5 of 6 infusions of
docetaxel
).
I have been advised about the risk of clots forming during air travel and in particular while undergoing chemotherapy (I have completed 5 of 6 infusions of
docetaxel
).
Ian2017
in
Advanced Prostate Cancer
6 years ago
"Pig Pen rides again-Or Docetaxel is skin poison.
Every move I make leaves a visible cloud of skin flakes floating behind me. I didn't know a person could shed enough skin to turn your dark colored underwear white and have an actual cloud float around you.. You can after 9 cycles of Chemo. Two weeks into this cycle and I'm just starting to function
Every move I make leaves a visible cloud of skin flakes floating behind me. I didn't know a person could shed enough skin to turn your dark colored underwear white and have an actual cloud float around you.. You can after 9 cycles of Chemo. Two weeks into this cycle and I'm just starting to function
Shooter1
in
Advanced Prostate Cancer
6 years ago
I am new here, I am from Australia, I have extensive mets.
Last year I had 6 courses of
Docetaxel
which was not fun.The PSA has been about 5 to 7 for 3 months. The PSA at diagnosis was 512. A recent PSMA/Pet/CT shows a lot of assymptomatic PSMA avid disease. I will have my first dose of Lutetium 177 PSMA in 2 weeks.
Last year I had 6 courses of
Docetaxel
which was not fun.The PSA has been about 5 to 7 for 3 months. The PSA at diagnosis was 512. A recent PSMA/Pet/CT shows a lot of assymptomatic PSMA avid disease. I will have my first dose of Lutetium 177 PSMA in 2 weeks.
Metungboy
in
Advanced Prostate Cancer
6 years ago
Quality of Life in Second-Line Treatment of Metastatic Castration-Resistant Prostate
Found a very interesting article on a trial done in Switzerland regarding quality of life in MCRPC patients who took different second-line treatments after ADT and
Docetaxel
chemotherapy. So many of the guidelines for second-line treatments I've found refer to "Chemotherapy-Naive" patients.
Found a very interesting article on a trial done in Switzerland regarding quality of life in MCRPC patients who took different second-line treatments after ADT and
Docetaxel
chemotherapy. So many of the guidelines for second-line treatments I've found refer to "Chemotherapy-Naive" patients.
Hidden
in
Advanced Prostate Cancer
6 years ago
Rechallenge with Xtandi
Last chemo
Docetaxel
/Carboplatin chemo cycle was 1/9/18 and PSA had fallen from 10.8 to .4. While on my chemo break, PSA started to rise again, so about 2 1/2 weeks ago, we decided to give Xtandi a second chance.
Last chemo
Docetaxel
/Carboplatin chemo cycle was 1/9/18 and PSA had fallen from 10.8 to .4. While on my chemo break, PSA started to rise again, so about 2 1/2 weeks ago, we decided to give Xtandi a second chance.
vandy69
in
Advanced Prostate Cancer
6 years ago
Antioxidants - Pro-oxidants.
[XC] Cabazitaxel [Jevtana] [XC1] "Cabazitaxel showed significantly higher cytotoxic efficacy than
docetaxel
in human CRPC cells, accompanied by elevated ROS production" "To investigate whether cabazitaxel-mediated cell death was caused by the ROS generation induced by cabazitaxel, we treated CRPC cells
[XC] Cabazitaxel [Jevtana] [XC1] "Cabazitaxel showed significantly higher cytotoxic efficacy than
docetaxel
in human CRPC cells, accompanied by elevated ROS production" "To investigate whether cabazitaxel-mediated cell death was caused by the ROS generation induced by cabazitaxel, we treated CRPC cells
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Burden of Metastatic Castrate Naive Prostate Cancer Patients, to Identify Men More Likely to Benefit from Early Docetaxel.
Low-volume patients have longer overall survival with ADT alone, and the toxicity of
docetaxel
may outweigh its benefits." Does "low" end where "high" begins? Or is there a fuzzy middle-volume area, where patients & doctors are going to agonize over whether to use
Docetaxel
early?
Low-volume patients have longer overall survival with ADT alone, and the toxicity of
docetaxel
may outweigh its benefits." Does "low" end where "high" begins? Or is there a fuzzy middle-volume area, where patients & doctors are going to agonize over whether to use
Docetaxel
early?
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Polyphenols - Inflammation.
CA-phenyl ester (CAPE) enhances anti-proliferative and cytotoxic effects of
docetaxel
(DOC) and paclitaxel (PTX) in PCa cells attributed to CAPE augmentation of DOC and PTX proapoptotic effects in addition to CAPE-induced alterations in estrogen receptors (ER)-α and ER-β abundance [23,24].
CA-phenyl ester (CAPE) enhances anti-proliferative and cytotoxic effects of
docetaxel
(DOC) and paclitaxel (PTX) in PCa cells attributed to CAPE augmentation of DOC and PTX proapoptotic effects in addition to CAPE-induced alterations in estrogen receptors (ER)-α and ER-β abundance [23,24].
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Need some help
I was diagnosed December 2012 age 53 Gleason 9 PSA 3.6 no symptoms just the result of a well man check up My bone scan at diagnosis is below, i will list my treatments so far Jan 13, 9 cycles
Docetaxel
, Denosumab, Zoladex and 5 days of RT to pelvis to prevent fracture After finishing Chemo i went straight
I was diagnosed December 2012 age 53 Gleason 9 PSA 3.6 no symptoms just the result of a well man check up My bone scan at diagnosis is below, i will list my treatments so far Jan 13, 9 cycles
Docetaxel
, Denosumab, Zoladex and 5 days of RT to pelvis to prevent fracture After finishing Chemo i went straight
siness
in
Advanced Prostate Cancer
6 years ago
Docetaxel for Prostate Cancer: 'Win-Win-Win'Nick Mulcahy
Compared with standard of care,
docetaxel
was cost-effective in both M1 patients and M0 patients. A sensitivity analysis indicated a "very high probability" (>99%) that
docetaxel
is cost-effective in both M0 and M1 patients, the authors also stated.
Compared with standard of care,
docetaxel
was cost-effective in both M1 patients and M0 patients. A sensitivity analysis indicated a "very high probability" (>99%) that
docetaxel
is cost-effective in both M0 and M1 patients, the authors also stated.
Hidden
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium (STAMPEDE update)
"Addition of
docetaxel
to first-line long-term hormone therapy in prostate cancer (STAMPEDE)".
"Addition of
docetaxel
to first-line long-term hormone therapy in prostate cancer (STAMPEDE)".
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Newbie with questions
I’m treating with Firmagon and Xgeva every 4 weeks, casodex and prednisone daily,
docetaxel
and neulasta every 3 weeks. Plan is to add Zytiga after we finish the 6
docetaxel
treatments. I wouldn’t wish
Docetaxel
on my worst enemy, but i’m over half finished.
I’m treating with Firmagon and Xgeva every 4 weeks, casodex and prednisone daily,
docetaxel
and neulasta every 3 weeks. Plan is to add Zytiga after we finish the 6
docetaxel
treatments. I wouldn’t wish
Docetaxel
on my worst enemy, but i’m over half finished.
Canoehead
in
Advanced Prostate Cancer
7 years ago
Drug 17777 or ODM-201
Husband is in clinical trial combining
docetaxel
and ODM-201. I was wondering if anyone here is on that same regimen.? Also lupron .
Husband is in clinical trial combining
docetaxel
and ODM-201. I was wondering if anyone here is on that same regimen.? Also lupron .
Cynthgob
in
Advanced Prostate Cancer
7 years ago
Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)
Lenalidomide &
Docetaxel
turns out to be a bad idea, as the Mainsail study discovered [1]: "we randomly assigned chemotherapy-naive patients with progressive metastatic castration-resistant prostate cancer in a 1:1 ratio to receive
docetaxel
(75 mg/m(2)) on day 1 and prednisone (5 mg twice daily) on
Lenalidomide &
Docetaxel
turns out to be a bad idea, as the Mainsail study discovered [1]: "we randomly assigned chemotherapy-naive patients with progressive metastatic castration-resistant prostate cancer in a 1:1 ratio to receive
docetaxel
(75 mg/m(2)) on day 1 and prednisone (5 mg twice daily) on
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (ARV7/AR ratio and neutrophil-to-lymphocyte ratio (NLR) as predictors of docetaxel benefit)
Conclusions: The combination of low ARV7/ARFL high NLR and ratio evaluated in PBMC prior to
docetaxel
treatment has a predictive impact on response and survival in mCRPC patients.
Conclusions: The combination of low ARV7/ARFL high NLR and ratio evaluated in PBMC prior to
docetaxel
treatment has a predictive impact on response and survival in mCRPC patients.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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