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Arzerra (ofatumumab) PBS listed in Australia
[i]ARZERRA (ofatumumab) in combination with
chlorambucil
will be listed on the Pharmaceutical Benefits Scheme as of 01 Apr 2015 for patients with CLL [u]who have not received prior therapy and are inappropriate for fludarabine-based therapy[/u], GlaxoSmithKline has said.
[i]ARZERRA (ofatumumab) in combination with
chlorambucil
will be listed on the Pharmaceutical Benefits Scheme as of 01 Apr 2015 for patients with CLL [u]who have not received prior therapy and are inappropriate for fludarabine-based therapy[/u], GlaxoSmithKline has said.
AussieNeil
Partner
in
CLL Support
9 years ago
Chlorambucil again
Hi everyone, I think it is generally believed that fludarabin monotherapy does not improve overall survival compared to classic therapy
chlorambucil
monotherapy. Then, does
chlorambucil
monotherapy improve overall survival compared to non-treated patients?
Hi everyone, I think it is generally believed that fludarabin monotherapy does not improve overall survival compared to classic therapy
chlorambucil
monotherapy. Then, does
chlorambucil
monotherapy improve overall survival compared to non-treated patients?
Miee
in
CLL Support
9 years ago
chlorambucil
Hi everyone, I think that
chlorambucil
was mainly used for CLL treatment before FRC was formulated. Today,
chlorambucil
is sometimes used instead of FCR. Is this the reason why
chlorambucil
is not so strong drug and so good for old patients? Miee
Hi everyone, I think that
chlorambucil
was mainly used for CLL treatment before FRC was formulated. Today,
chlorambucil
is sometimes used instead of FCR. Is this the reason why
chlorambucil
is not so strong drug and so good for old patients? Miee
Miee
in
CLL Support
9 years ago
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Doubled wbc count good or bad?
So my father in laws latest test results came back after a week of
chlorambucil
... Wbc down to 51 (from 100), platelets down to 10 (from 40) at diagnosis ... He claims he read somewhere that doubling wbc count is a good prognosis...
So my father in laws latest test results came back after a week of
chlorambucil
... Wbc down to 51 (from 100), platelets down to 10 (from 40) at diagnosis ... He claims he read somewhere that doubling wbc count is a good prognosis...
marcelarr
in
CLL Support
9 years ago
Has anyone had eight months of treatment using Rituxan and Treanda (bendamustine)
Treatment began using Leukkeran (
chlorambucil
) dexamethasone and allopurinol. Had 5 treatments from October 2007 to February 2008. WBC started increasing so treatment stopped. Back to W&W. In July 2008 began treatment using Rituxan and Cytoxan.
Treatment began using Leukkeran (
chlorambucil
) dexamethasone and allopurinol. Had 5 treatments from October 2007 to February 2008. WBC started increasing so treatment stopped. Back to W&W. In July 2008 began treatment using Rituxan and Cytoxan.
Janetfld
in
CLL Support
9 years ago
Update on PCYC-1115-CA Randomised, Phase 3 study of Ibrutinib/Imbruvica versus Chlorambucil in Patients 65 yrs + and untreated with CLL/SLL.
Day 1 of cycle 15 yesterday and continuing onwards and upwards :) FBC looking good with Hg 153.00, WBC 6.7, RBC 4.71, ALC 1.8, platelets 118, neutrophils 4.1. Biochemistry also good with LFT and Renal profile normal and GFR 84.00. LDH 181.00 and B2M 2.4 (norm at Bournemouth lab 1.4 - 2.4) Another
Day 1 of cycle 15 yesterday and continuing onwards and upwards :) FBC looking good with Hg 153.00, WBC 6.7, RBC 4.71, ALC 1.8, platelets 118, neutrophils 4.1. Biochemistry also good with LFT and Renal profile normal and GFR 84.00. LDH 181.00 and B2M 2.4 (norm at Bournemouth lab 1.4 - 2.4) Another
Mikey47
in
CLL Support
10 years ago
What is the treatment for Sweet's syndrome?
Other treatments include tetracycline antibiotics; infliximab; immunoglobulin; methotrexate;
chlorambucil
; cyclophosamide; interferon alpha; anakinra. Read more about treatment options @ http://helpforsweetssyndromeuk.wordpress.com/key-information/what-is-the-treatment-for-sweets-syndrome/
Other treatments include tetracycline antibiotics; infliximab; immunoglobulin; methotrexate;
chlorambucil
; cyclophosamide; interferon alpha; anakinra. Read more about treatment options @ http://helpforsweetssyndromeuk.wordpress.com/key-information/what-is-the-treatment-for-sweets-syndrome/
Shell567
Sweet's Syndrome UK
in
Sweet's Syndrome UK
10 years ago
Update on PCYC-1115-CA Randomised, Phase 3 study of Ibrutinib/Imbruvica versus Chlorambucil in Patients 65 yrs + and untreated with CLL/SLL.
Day 1 of cycle 12 today and with the exception of my platelets, (fluctuating around 100) and my low Immunoglobulins, all counts are in the normal range. Lymphocytes 2.4, LDH 222, B2m 2.8 (a month ago) and WBC 7.5. Biochemistry all in normal range also. A CT scan and possibly BMB next month will reveal
Day 1 of cycle 12 today and with the exception of my platelets, (fluctuating around 100) and my low Immunoglobulins, all counts are in the normal range. Lymphocytes 2.4, LDH 222, B2m 2.8 (a month ago) and WBC 7.5. Biochemistry all in normal range also. A CT scan and possibly BMB next month will reveal
Mikey47
in
CLL Support
10 years ago
GAZYVA® (Obinutuzumab) gains TGA approval for 1st line treatment of CLL in combination with Chlorambucil in Australia
In the CLL11 GAZYVA study, GAZYVA +
Chlorambucil
: * More than doubled Progression Free Survival (PFS) vs
Chlorambucil
alone (26.7 vs 11.1 months) * Provided nearly 1-year improvement in PFS vs MabThera (Rituximab) +
Chlorambucil
(26.7 vs 15.2 months) This follows FDA approval 7 months ago: https:/
In the CLL11 GAZYVA study, GAZYVA +
Chlorambucil
: * More than doubled Progression Free Survival (PFS) vs
Chlorambucil
alone (26.7 vs 11.1 months) * Provided nearly 1-year improvement in PFS vs MabThera (Rituximab) +
Chlorambucil
(26.7 vs 15.2 months) This follows FDA approval 7 months ago: https:/
AussieNeil
Partner
in
CLL Support
10 years ago
Australians - here's your opportunity to support the listing of GAZYVA (Obinutuzimab) on the PBS - Deadline is Wed 11th June!
GAZYVA +
: [i] * More than doubled Progression Free Survival (PFS) vs
Chlorambucil
alone (26.7 vs 11.1 months) * Provided nearly 1-year improvement in PFS vs MabThera (Rituximab) +
Chlorambucil
(26.7 vs 15.2 months) [/i] As the PBAC site says: "Your comments are welcome whether you
GAZYVA +
: [i] * More than doubled Progression Free Survival (PFS) vs
Chlorambucil
alone (26.7 vs 11.1 months) * Provided nearly 1-year improvement in PFS vs MabThera (Rituximab) +
Chlorambucil
(26.7 vs 15.2 months) [/i] As the PBAC site says: "Your comments are welcome whether you
AussieNeil
Partner
in
CLL Support
10 years ago
Dr Sharman on Management of CLL in Elderly
Oncology on Management of CLL in Elderly/Frail patients on his blog: http://www.cll-nhl.com/2014/06/management-of-cll-in-elderly-cll-asco.html Just clicking through them will give you an appreciation of how the newer drugs are improving the outcome for older patients, including when partnered with
Chlorambucil
Oncology on Management of CLL in Elderly/Frail patients on his blog: http://www.cll-nhl.com/2014/06/management-of-cll-in-elderly-cll-asco.html Just clicking through them will give you an appreciation of how the newer drugs are improving the outcome for older patients, including when partnered with
Chlorambucil
AussieNeil
Partner
in
CLL Support
10 years ago
RIAltO: I am about to take part in a Randomised Investigation of Alternative Ofatumumab: designed to compare ofatumumab with chlorambucil.
I'd like to compare notes with other people experiencing this investigation which is based in Liverpool; and especially with anyone who has already experienced this treatment. I am 77 years old but this is my first serious illness and always been in good health. No idea really what to expect during the
I'd like to compare notes with other people experiencing this investigation which is based in Liverpool; and especially with anyone who has already experienced this treatment. I am 77 years old but this is my first serious illness and always been in good health. No idea really what to expect during the
johnpollard37
in
CLL Support
10 years ago
Update on PCYC-1115-CA Randomised, Phase 3 study of Ibrutinib/Imbruvica versus Chlorambucil in Patients 65 yrs and untreated with CLL/SLL.
This is the first significant change to report, other than the reduction of lymph nodes after the first few weeks on the study which I began in September. (My neck, axillae and groin all clear now). On Tuesday I had a CT scan at Bournemouth and on Thursday, the first 'study day' of my 5th cycle, I
This is the first significant change to report, other than the reduction of lymph nodes after the first few weeks on the study which I began in September. (My neck, axillae and groin all clear now). On Tuesday I had a CT scan at Bournemouth and on Thursday, the first 'study day' of my 5th cycle, I
Mikey47
in
CLL Support
10 years ago
Dr Peter Hillmen of Leeds, UK discusses the place for Idelalisib in CLL treatment (Patient Power Video)
[/i] http://www.patientpower.info/video/where-a-pi3k-inhibitor-could-fit-in-for-cll Interesting to hear that in contrast to the Patient Power introduction, in the UK, Dr Hillmen sees Idelalisib as likely to have a place with a chemotherapy backbone of
Chlorambucil
+ Ofatumumab or Bendamustine + Ofatumumab
[/i] http://www.patientpower.info/video/where-a-pi3k-inhibitor-could-fit-in-for-cll Interesting to hear that in contrast to the Patient Power introduction, in the UK, Dr Hillmen sees Idelalisib as likely to have a place with a chemotherapy backbone of
Chlorambucil
+ Ofatumumab or Bendamustine + Ofatumumab
AussieNeil
Partner
in
CLL Support
11 years ago
Obinutuzumab was approved for treatment naive patients, but in only in combination with chlorambucil.
Friends Obinutuzumab was approved for treatment naive patients, but in only in combination with
chlorambucil
. That is a very limited indication and I don't like that You might want to read my blog commentary on the issues swirling around this FDA decision.
Friends Obinutuzumab was approved for treatment naive patients, but in only in combination with
chlorambucil
. That is a very limited indication and I don't like that You might want to read my blog commentary on the issues swirling around this FDA decision.
bkoffman
CLL CURE Hero
in
CLL Support
11 years ago
on Ibrutinib for less than 2 weeks and lymph node in my neck have gone from silver $ size and about 3/8 inch thick toa little larger
MD Anderson has a clinical trial going on now , randomized , open testing
Chlorambucil
and Ibrutinib... I got the Ibrutinib.... only thing is the bone marrow test (8 days ago ) still hurts like hell. Good luck fish61
MD Anderson has a clinical trial going on now , randomized , open testing
Chlorambucil
and Ibrutinib... I got the Ibrutinib.... only thing is the bone marrow test (8 days ago ) still hurts like hell. Good luck fish61
fish61
in
CLL Support
11 years ago
Marketing authorisation application submitted to the European Medicines Agency for the use of ofatumumab for first line treatment
The submission is based primarily on results from an international, multi-centre, randomised phase III study of ofatumumab in combination with
chlorambucil
versus
chlorambucil
alone in more than 400 patients with previously untreated CLL. http://www.pharmabiz.com/NewsDetails.aspx?
The submission is based primarily on results from an international, multi-centre, randomised phase III study of ofatumumab in combination with
chlorambucil
versus
chlorambucil
alone in more than 400 patients with previously untreated CLL. http://www.pharmabiz.com/NewsDetails.aspx?
AussieNeil
Partner
in
CLL Support
11 years ago
Starting treatment soon. Have opted for Bendamustine (Levact) over Fludarabine + Rituximab. Any observations?
A trial called RIAltO comparing the use of Ofatumumab +
Chlorambucil
and Ofatumumab + Bendamustine was offered but I declined at this time. I was diagnosed in July 2013 and had a CT scan 3 weeks ago which showed my spleen to be bigger than my liver. Thus the beginning of treatment. Maureen
A trial called RIAltO comparing the use of Ofatumumab +
Chlorambucil
and Ofatumumab + Bendamustine was offered but I declined at this time. I was diagnosed in July 2013 and had a CT scan 3 weeks ago which showed my spleen to be bigger than my liver. Thus the beginning of treatment. Maureen
maureenmckeown
in
CLL Support
11 years ago
Arzerra(R) (Ofatumumab) granted FDA 'Breakthrough Therapy Designation' for Previously Untreated CLL
Genmab A/S and GlaxoSmithKline plc (GSK) announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy designation for Arzerra(r) (ofatumumab) in combination with
chlorambucil
for the treatment of patients with chronic lymphocytic leukemia (CLL) who have not received prior
Genmab A/S and GlaxoSmithKline plc (GSK) announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy designation for Arzerra(r) (ofatumumab) in combination with
chlorambucil
for the treatment of patients with chronic lymphocytic leukemia (CLL) who have not received prior
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Obinutuzumab (GA101) delayed disease progression longer than MabThera/Rituxan - Roche press release on CLL11 study
chlorambucil
.
chlorambucil
.
AussieNeil
Partner
in
CLL Support
11 years ago
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