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Axitinib
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Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?
Doxazosin
, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
Doxazosin
, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
Hidden
in
Advanced Prostate Cancer
1 year ago
Help and advice please.
Hello again everyone. I have just started on Tagisso which my doctor said is unlikely to work because my tumour doesn't have the right genetic 'make up'. But I live in hope, what else is there. He also said that if it didn't work there was nothing left. Over the past 2 years I have had Afatinib, immunotherapy
Hello again everyone. I have just started on Tagisso which my doctor said is unlikely to work because my tumour doesn't have the right genetic 'make up'. But I live in hope, what else is there. He also said that if it didn't work there was nothing left. Over the past 2 years I have had Afatinib, immunotherapy
sally70
in
The Roy Castle Lung Cancer Foundation
1 year ago
Radiotherapy
Hi just an update Have stage 4 lung but seems to be stable last scan showed my hip has been nibbled so having to have 5 rounds of radiotherapy Got my last bit of welding tomorrow I don’t Know if anybody else has had diarrhoea but Iv been terrible even a biscuit ! Anyway I’m still taking afatinib and
Hi just an update Have stage 4 lung but seems to be stable last scan showed my hip has been nibbled so having to have 5 rounds of radiotherapy Got my last bit of welding tomorrow I don’t Know if anybody else has had diarrhoea but Iv been terrible even a biscuit ! Anyway I’m still taking afatinib and
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
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A large injection of hope required. Please.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs. I then had five consecutive radiotherapy sessions which reduced the size of the main tumour
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs. I then had five consecutive radiotherapy sessions which reduced the size of the main tumour
sally70
in
Lung Cancer Support
2 years ago
Rash
Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Makeup
Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Face rash
Hi I’m on afatinib 50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Hi I’m on afatinib 50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
After 10 mnths on Afatinib my tumour regrew.My consultant described it as behaving atypically. Does this mean it has changed to small cell.
NSCLung cancer changing to small cell.
NSCLung cancer changing to small cell.
sally70
in
Lung Cancer Support
2 years ago
Skin rash
Hi I was diagnosed with stage 4 lung cancer in February and I am now taking afatinib and the tumour has shrunk thank goodness tho now after all this time my arms and stomach have broke out in the “rash” I was told to plaster myself in cetriban but was wondering does anybody have any tips
Hi I was diagnosed with stage 4 lung cancer in February and I am now taking afatinib and the tumour has shrunk thank goodness tho now after all this time my arms and stomach have broke out in the “rash” I was told to plaster myself in cetriban but was wondering does anybody have any tips
Rusty821
in
The Roy Castle Lung Cancer Foundation
3 years ago
Trying to keep busy
I personally have problems getting motivated. I am watching too much rubbish on the tele, eating too many crisps and ice cream. I am about to run out of goodies. Hopefully my next Sainsburys delivery will have some of the treats I ask for. :) I am very lucky that I have a tiny patio and some pots so
I personally have problems getting motivated. I am watching too much rubbish on the tele, eating too many crisps and ice cream. I am about to run out of goodies. Hopefully my next Sainsburys delivery will have some of the treats I ask for. :) I am very lucky that I have a tiny patio and some pots so
nikkidolls
in
The Roy Castle Lung Cancer Foundation
3 years ago
Adenocarcinoma of Lung
Hi ! I’m new to this . My husband was diagnosed with metastatic adenocarcinoma of lung cancer (T4N3M1A) last month. He is on Afatinib the last two weeks but he is suffering from all three blowup of the side affects in the first week , mouth sore/ ulcers , , diarrhoea, face n chest rashes. Has been in
Hi ! I’m new to this . My husband was diagnosed with metastatic adenocarcinoma of lung cancer (T4N3M1A) last month. He is on Afatinib the last two weeks but he is suffering from all three blowup of the side affects in the first week , mouth sore/ ulcers , , diarrhoea, face n chest rashes. Has been in
Ace467
in
The Roy Castle Lung Cancer Foundation
3 years ago
Treatments after Immunotherapy
Now I am without treatment and my doctors propose
Axitinib
or participate in a trial of Votrient, which is not yet approved for the use of patients who have done immunotherapy. Is anyone in one of these programs? Has anyone used
Axitinib
and Votrient and which of them has been more toxic?
Now I am without treatment and my doctors propose
Axitinib
or participate in a trial of Votrient, which is not yet approved for the use of patients who have done immunotherapy. Is anyone in one of these programs? Has anyone used
Axitinib
and Votrient and which of them has been more toxic?
Mafaldaaa
in
Kidney Cancer Support
4 years ago
Target Therapy for NSCLC stage 3 with EGFR mutation ?
My husband recently had results confirming the re-occurrence of his lung cancer. As a second line treatment he is being offered a target treatment. His oncologist is trying to get a new treatment funded for him called Dacomitinib. Is anyone using this new drug, and if so how is it going so far? We have
My husband recently had results confirming the re-occurrence of his lung cancer. As a second line treatment he is being offered a target treatment. His oncologist is trying to get a new treatment funded for him called Dacomitinib. Is anyone using this new drug, and if so how is it going so far? We have
e-priestman
in
The Roy Castle Lung Cancer Foundation
4 years ago
Afatinib
I’m just wondering if anyone can give some experienced advice. My mum has been taking Afatinib for her lung cancer on a 20mg dose. The tablet has been doing its job, however my mums eyes have been very sore, should already suffers with dry eyes. My question is how she should be handling rest periods
I’m just wondering if anyone can give some experienced advice. My mum has been taking Afatinib for her lung cancer on a 20mg dose. The tablet has been doing its job, however my mums eyes have been very sore, should already suffers with dry eyes. My question is how she should be handling rest periods
Bella426
in
The Roy Castle Lung Cancer Foundation
4 years ago
Afatanib side effects
Hi All My 71yo mother in law was recently diagnosed with adenocarcinoma stage 4. She was fit with very little symptoms. She has been taking Afatinib for 10 days now and is really struggling with side effects. She has diahorrea several times a day, acne rash on upper body particularly bad on her scalp
Hi All My 71yo mother in law was recently diagnosed with adenocarcinoma stage 4. She was fit with very little symptoms. She has been taking Afatinib for 10 days now and is really struggling with side effects. She has diahorrea several times a day, acne rash on upper body particularly bad on her scalp
MsLiz
in
The Roy Castle Lung Cancer Foundation
4 years ago
News from the FDA: the indication for a drug targeting EGFR is expanded to uncommon mutations
The FDA has expanded the indication for afatinib (Gilotrif) to include the treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors have uncommon EGFR alterations in L861Q, G719X, and/or S768I. http://www.onclive.com/web-exclusives/fda-expands-afatinibs-approval-for-lung-cancer
The FDA has expanded the indication for afatinib (Gilotrif) to include the treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors have uncommon EGFR alterations in L861Q, G719X, and/or S768I. http://www.onclive.com/web-exclusives/fda-expands-afatinibs-approval-for-lung-cancer
MFH_Advocate
in
Lung Cancer Support
5 years ago
Growing fatigue and getting no answers
Hi am stage IV adenocarcinoma diagnosed August 2014, been on afatinib 20 mg all this time. Fortunately still here but the last 6 months have seen not a change in tumour size as per scans. However last 6 months has seen fatigue, mixing up words, needing to walk with stick, balance issues. According to
Hi am stage IV adenocarcinoma diagnosed August 2014, been on afatinib 20 mg all this time. Fortunately still here but the last 6 months have seen not a change in tumour size as per scans. However last 6 months has seen fatigue, mixing up words, needing to walk with stick, balance issues. According to
tdes69
in
The Roy Castle Lung Cancer Foundation
6 years ago
NSCLC EDFR Migration Stage 4 LC at 37.
Hi guys. I'm Adam, I was diagnosed last April at the age of 37 with Stage 4 Lung Cancer which had spread to my spine. It was caught on an X-ray of my throat completely unrelated to the cancer. As a lifetime non-smoker it was a complete shock (and still is). Turns out it was due to DNA mutation). Ive
Hi guys. I'm Adam, I was diagnosed last April at the age of 37 with Stage 4 Lung Cancer which had spread to my spine. It was caught on an X-ray of my throat completely unrelated to the cancer. As a lifetime non-smoker it was a complete shock (and still is). Turns out it was due to DNA mutation). Ive
AdamLaver
in
The Roy Castle Lung Cancer Foundation
6 years ago
Gilotrif/Afatinib
52 years old and have stage 4 lung cancer. I am EGFR positive and have been taking gilotrif/ Afatinib for almost 2 months now. I was wondering if there is anyone out there on this drug and is it working? I will have scans again on the 17th. Of this month. I try and stay positive.
52 years old and have stage 4 lung cancer. I am EGFR positive and have been taking gilotrif/ Afatinib for almost 2 months now. I was wondering if there is anyone out there on this drug and is it working? I will have scans again on the 17th. Of this month. I try and stay positive.
Deb1516
in
Lung Cancer Support
6 years ago
any supporters in Bristol
I was wondering whether there is any one using this site who are on the targeted therapy Afatinib (Giotrif) in the Bristol area- or are supporter or partner of any one on this drug or any other therapy for lung or other terminal cancer? it would be good to link up ? x
I was wondering whether there is any one using this site who are on the targeted therapy Afatinib (Giotrif) in the Bristol area- or are supporter or partner of any one on this drug or any other therapy for lung or other terminal cancer? it would be good to link up ? x
TraClo
in
Lung Cancer Support
7 years ago
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