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Experiences with
Androgen deprivation therapy (ADT)
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Are endocrinologists of any help after ADT?
After
ADT
, my MO told me that handling things like Prolia management won't be in her bailiwick. I didn't ask about post-
ADT
SE's and recovery from same. Hot flashes, low T, BMD loss, and last not least sarcopenia. What is the community's experience with how post-treatment SE's are best handled?
After
ADT
, my MO told me that handling things like Prolia management won't be in her bailiwick. I didn't ask about post-
ADT
SE's and recovery from same. Hot flashes, low T, BMD loss, and last not least sarcopenia. What is the community's experience with how post-treatment SE's are best handled?
Derf4223
in
Advanced Prostate Cancer
1 month ago
Decipher question
But Decipher, which focuses on various statistics, doesn't say what the improvement would be with
ADT
. Does my chance of meta go down significantly by adding
ADT
?
But Decipher, which focuses on various statistics, doesn't say what the improvement would be with
ADT
. Does my chance of meta go down significantly by adding
ADT
?
gualala
in
Prostate Cancer Network
3 months ago
After ADT
PSAs have been zero. 2 weeks ago
ADT
& steroids were stopped. The steroids were not weaned. Now he has adrenal insufficiency. Symptoms were mainly extreme fatigue & weakness. The GP put him on hydrocortisone tabs. He has constant nausea.
PSAs have been zero. 2 weeks ago
ADT
& steroids were stopped. The steroids were not weaned. Now he has adrenal insufficiency. Symptoms were mainly extreme fatigue & weakness. The GP put him on hydrocortisone tabs. He has constant nausea.
Catmama5
in
Advanced Prostate Cancer
22 days ago
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No Osteoporosis with Estrogen Patch Therapy
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron
ADT
. These plots show that Lupron
ADT
causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron
ADT
. These plots show that Lupron
ADT
causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
janebob99
in
Prostate Cancer Network
3 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
.
janebob99
in
Prostate Cancer Network
2 months ago
Using Enzalutamide, Darolutamide, Apalutamide only.
I'm particularly interested if you transitioned to a "mide" only from first level
ADT
only, and are metastatic to bones/organs. Thanks.
I'm particularly interested if you transitioned to a "mide" only from first level
ADT
only, and are metastatic to bones/organs. Thanks.
dhccpa
in
Prostate Cancer Network
2 months ago
Silly Questions??
1) Why do some advanced prostate cancer patients get offered "vacations", from
ADT
and others don't? 2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to
ADT
+ Abiraterone+Prednisone, while others begin treatment with chemo and radiation?
1) Why do some advanced prostate cancer patients get offered "vacations", from
ADT
and others don't? 2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to
ADT
+ Abiraterone+Prednisone, while others begin treatment with chemo and radiation?
TommyCarz2
in
Advanced Prostate Cancer
3 months ago
On treating micro-metastatic disease
Thereafter just monitor the PSA for any rise, and use PSMA PET scan to locate any cancer and to radiate whatever spots of cancer that are found.This May I will reach the one year mark of my
ADT
and seriously considering stopping the
ADT
because of the side effects... fatigue, muscle loss, forgetfulness
Thereafter just monitor the PSA for any rise, and use PSMA PET scan to locate any cancer and to radiate whatever spots of cancer that are found.This May I will reach the one year mark of my
ADT
and seriously considering stopping the
ADT
because of the side effects... fatigue, muscle loss, forgetfulness
John347
in
Advanced Prostate Cancer
3 months ago
Proton Treatment - When to start the ADT relative to simulation and CT of the prostate
Another doctor tells me I should start the
ADT
at the same time as I do the space OAR and simulation and cat scan, which will precede the start of the radiation by maybe 2 weeks. My concern about the second doctor's protocol is that the
ADT
will shrink the prostate and the tumors.
Another doctor tells me I should start the
ADT
at the same time as I do the space OAR and simulation and cat scan, which will precede the start of the radiation by maybe 2 weeks. My concern about the second doctor's protocol is that the
ADT
will shrink the prostate and the tumors.
CBRD
in
Advanced Prostate Cancer
2 months ago
New data about ARASENS trial: it seems to work well after longer observation
Post-Hoc Analysis of ARASENS Reinforces Use of Darolutamide/
ADT
/Docetaxel Combo as SOC in mHSPC https://www.onclive.com/view/post-hoc-analysis-of-arasens-reinforces-use-of-darolutamide-
adt
-docetaxel-combo-as-soc-in-mhspc
Post-Hoc Analysis of ARASENS Reinforces Use of Darolutamide/
ADT
/Docetaxel Combo as SOC in mHSPC https://www.onclive.com/view/post-hoc-analysis-of-arasens-reinforces-use-of-darolutamide-
adt
-docetaxel-combo-as-soc-in-mhspc
Maxone73
in
Advanced Prostate Cancer
4 months ago
ADT or Orchiectomy & side effects
I have been on
ADT
for 18 months the Side effects are a little better but still horrible!! Q) If i have a Orchiectomy, can I stop the
ADT
therapy altogether? Currently on Xtandi and Orgovox. thanks
I have been on
ADT
for 18 months the Side effects are a little better but still horrible!! Q) If i have a Orchiectomy, can I stop the
ADT
therapy altogether? Currently on Xtandi and Orgovox. thanks
lookout4
in
Advanced Prostate Cancer
3 months ago
ADT & Mets
Are we wasting time going onto
ADT
if that treatment is mainly for contained PCa? Or will the
ADT
put a lid on the Mets wherever they are in our body? Keep in mind that we are totally oblivious of having Mets at the time of starting
ADT
.
Are we wasting time going onto
ADT
if that treatment is mainly for contained PCa? Or will the
ADT
put a lid on the Mets wherever they are in our body? Keep in mind that we are totally oblivious of having Mets at the time of starting
ADT
.
CJ1958
in
Advanced Prostate Cancer
3 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
If you have had surgery, Salvage Radiation,
ADT
, SRBT and then stopped
ADT
with a continuing rise in you PSA when did you start to have pain or physical problems?
If you have had surgery, Salvage Radiation,
ADT
, SRBT and then stopped
ADT
with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
2 months ago
ARASENS TRIAL: Darolutamide
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide +
ADT
+ Docetaxel, versus (B) Placebo +
ADT
+ Docetaxel.
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide +
ADT
+ Docetaxel, versus (B) Placebo +
ADT
+ Docetaxel.
janebob99
in
Advanced Prostate Cancer
2 months ago
Testosterone Recovery After ADT - Updated Plot
ADT
duration of 3-9 months fall roughly on the same curve, and
ADT
of 18-24 roughly fall on the same line. Bob
ADT
duration of 3-9 months fall roughly on the same curve, and
ADT
of 18-24 roughly fall on the same line. Bob
janebob99
in
Prostate Cancer Network
3 months ago
Low Testosterone reduces Survival by a huge amount.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
. The important takeaway is that having a low testosterone (T < 280 ng/dL) after completing
ADT
is associated with
extremely poor
survival outcomes.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
. The important takeaway is that having a low testosterone (T < 280 ng/dL) after completing
ADT
is associated with
extremely poor
survival outcomes.
janebob99
in
Prostate Cancer Network
2 months ago
Why do MO's continue to prescribe Lupron ADT for Castrate-Resistant men?
I've never understood why MO's continue to prescribe Lupron
ADT
(or equivalent ) for men who are
castrate-resistant (CRPC
). Isn't that the definition of CRPC, namely, that
ADT
is no longer working for those men?
I've never understood why MO's continue to prescribe Lupron
ADT
(or equivalent ) for men who are
castrate-resistant (CRPC
). Isn't that the definition of CRPC, namely, that
ADT
is no longer working for those men?
janebob99
in
Advanced Prostate Cancer
26 days ago
Can we trust AI analysis?
The first chose no
ADT
with radiation and the second chose 12 months of
ADT
after surgery and follow up radiation after PSA rise. I guess only time and luck will tell if that was the correct decision for each of us.
The first chose no
ADT
with radiation and the second chose 12 months of
ADT
after surgery and follow up radiation after PSA rise. I guess only time and luck will tell if that was the correct decision for each of us.
Mgtd
in
Prostate Cancer Network
3 months ago
Sciatica
I went off
ADT
9 months ago after 6 months of Elegard depot treatment following prostate radiation. I know that many of the side effects of
ADT
can persist months and even years after stopping Elegard (Lupron).
I went off
ADT
9 months ago after 6 months of Elegard depot treatment following prostate radiation. I know that many of the side effects of
ADT
can persist months and even years after stopping Elegard (Lupron).
sciaticaman
in
Advanced Prostate Cancer
4 months ago
Effect of Baseline T on T-Recovery Time
Increasing the duration of
ADT
increases the T-recovery time, in general.
Increasing the duration of
ADT
increases the T-recovery time, in general.
janebob99
in
Prostate Cancer Network
3 months ago
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