Eye problems in Sweet's syndrome

[Shell567]

In 2015, it was reported that Sweet’s syndrome can affect the eyes in up to 72% of patients, and initial symptoms can include sore eyes, eye pain, and blurry vision.

Over the past few years, research has also revealed that it's possible to develop SS-related eye problems even when skin lesions are not present. Read more @ helpforsweetssyndromeuk.wor...

Michelle (admin).

[BonnieG567]

Tx.

[Shell567 Administrator Sweet's Syndrome UK]

Oral tacrolimus for ocular involvement in pediatric neutrophilic dermatoses, 2022.

"Neutrophilic dermatoses (ND), including pyoderma gangrenosum (PG) and SWEET SYNDROME (SS), are rare in children. One study showed that only 2% of PG cases occurred in patients younger than 18 years old. While both disorders are associated with extracutaneous features, ocular (EYE) involvement is uncommon and often a diagnostic challenge. One French case series found ocular involvement in less than 15% of the 27 pediatric patients with PG or SS. Ocular manifestations include conjunctivitis, iritis, scleritis, and retinal vasculitis. Periorbital inflammation and eyelid lesions are also considered ocular manifestations, as eyelid lesions can lead to decreased visual acuity and occasionally vision loss. Most of the current literature describes ocular involvement in adults and highlights the risk of misdiagnosis as cellulitis or other bacterial infections, chalazion, or malignancy, resulting in inappropriate treatment. Early recognition and timely initiation of immunosuppressive therapy are imperative to prevent ocular damage and unnecessary antimicrobial exposure."

CASE 1: 15 year old girl. History of juvenile idiopathic arthritis and dermatitis herpetiformis. Sweet's syndrome - persistent leg ulcer and conjunctivitis.

CASE 2: 12 year old girl. History of juvenile idiopathic arthritis, presumed septic arthritis, "culture-negative cutaneous abscesses (including on the upper eyelids), and 1 episode of left eye periorbital cellulitis, all refractory to systemic antimicrobials." PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, cystic acne). pubmed.ncbi.nlm.nih.gov/352...