I have the trait and so does my daughter. Tonight I decided to look up on line to see if others have the muscle and joint pain that I carry in which I believe stems from the trait. I asked doctors many years ago if the trait had anything to do with the pain and like everyone else they said no there is no effect . Well like most of you I beg the differ. Since I was a teenager and first introduce to the trait which had to be about 40 years ago I new that my body was going through some unusual changes. Now my daughter who's age is 35 is telling me that every now and again she is experiencing like pain. I'm happy to know that I'm not alone and we are not crazy. Weather change I feel brings on my crisis. I'm going through it as type this note. My dad had gout , I use to think it was gout but my Dr. Said no. I know my body and I know believe this stems from having the sickle cell trait.