Mets in the liver and Enhertu doesn't work - searching for other treatment

[deHans]

My very good friend has breast cancer since 2007 / relaps in 2018. Since Okt 2021 she has mets in bones and lymph nodes.

She took Fulvestrant, Ibrance and checkpointIn May 2022 there appears mets in liver and she started the programm of Jane Mclelland. In August 2022 the mets in liver increased rapidly and she searched for an other treatment.

She discovered "TACE and Ablation" of cancer center university Frankfurt / Prof. Vogl.

After the five treatment sequences in January 2023 the liver was clean

[Note: you have to pay it by your own - no cost absorption by the health insurance]

In June 2023 the mets are back...

Meanwhile Enhertu was available and so she started this treatment...

After six cycles of Enhertu last Friday she got a MRT.

Reault' Mets in the liver still grow - Enhertu doesn't work

Now our question:

Do you have suggestions/ ideas for other treatment?

[HelenWi]

Hello,

Treatment totally depends on the attributes of the cancer itself and we don’t know that information. Enhertu was probably given by your friend’s oncologist because of the outcome of genetic testing. Typically, after targeted therapies stop working, chemo is used. If you want to get second opinion, it is possible to get that from the top breast cancer centers such as Sloan Kettering and Dana Farber.

Best wishes.

[deHans in reply to HelenWi]

Thanks for the very quick response, the names of "top breast cancer centers" and best wishes

[Hazelgreen]

Hello deHans;

I have liver mets, along with many mets elsewhere. I've never taken cancer meds specifically for my liver because all my bloodwork measures of my liver's functioning are in the normal range. However, I take ribociclib (5 days on, 2 days off) and letrozole (daily) to keep all my cancer mets under control.

Your good friend is likely much younger than 78 years-old me, but the gap between her cancer diagnoses is similar to mine. I was diagnosed in 2006 and rediagnosed in 2019. If her liver is functioning okay, perhaps she'll find that ribociclib (it has the best research results overall) and letrozole is all she needs.

Best of wishes, Cindy

[deHans in reply to Hazelgreen]

Hello Cindy, I say thank you for the very quick response and "your list of drugs" that helps you It feels us not alone - thanks! All of you (HelenWiant, Figletf, Cindy,.. ) Be blessed Hans-Christoph

[Pups2Cute in reply to Hazelgreen]

My Mom is also 78 yrs young lol. We are in Canada too💕. The gap between your diagnosises is also close to my Mom’s. She was originally diagnosed with DCIS stage zero in 2006 and had a lumpectomy and radiation therapy to treat. Fast forward to 2020. A mass was found in the scar tissue of the right breast where my Mom had the lumpectomy and breast reduction surgery years earlier. The biopsy showed it was malignant and she had her right breast removed in August 2020. The following month she was supposed to start chemotherapy but then had a high resolution scan performed in Quebec. They determined that she actually had some small areas light up indicating MBC. She started on Ibrance and letrozole and was on that for over two years with NED. She went off Ibrance for approximately one month in Sept 2022 for knee replacement surgery and went for next scan last May 2023. So a nine month break between scans. The scan in May showed a liver met so my Mom was switched to Faslodex and was put on a trial since July 2023. Now my Mom’s oncologist isn’t sure if the Faslodex is keeping the liver met stable and thinks there could be slight growth. We are waiting to hear the official report from the radiologist. My Mom’s oncologist says it is a more slow growing cancer but she wants to be on top of it and change my Mom to an oral chemo pill if she sees it has grown. She said Mom can take a pill where she wouldn’t lose her hair and I’m not sure what it’s called. Anyhow, my Mom will either stay on the Faslodex with trial or move on to the oral med. it sounds E’s like your treatment plan is working well for you. My Mom has lobular and it’s apparently slow growing. We will see what the Onc has to say next week. Thank you again for your ongoing feedback about the various treatments. I hope you have a very Merry Christmas and happy and healthy new year!!

[Figletf]

Wow!She has been thru a lot.So,so sorry that nothing seems to stop the cancer from growing.Prayers that you do find a treatment that does help her.❤️

[deHans in reply to Figletf]

That's nice. Thank you

[Iwasborntodothis]

I am taking Trodelvy for my extensive liver mets after failed Carboplatin. It has brought all of my liver chemistry back to normal and is decreasing my tumor cancer marker levels by almost 20% per round (yesterday CA15 down to 300 after being in the 1000's or higher previously). I no longer have pain or swelling in my liver. I have done 8? rounds of this treatment and am hopeful to continue as the side effects are getting "easier" and more predictable. I have posted on this several times for a reference to others since it is a newer treatment and I am not on here that much. ...well some days more than others...

Allison

[deHans in reply to Iwasborntodothis]

That sounds very interesting - thank you. Wish you all the best!