Gabapentin

[Thebarber]

Hi, everyone. Can you tell me if over time will gabapentin stop working as other drugs have. Thanks

[SueJohnson]

No it won't stop working, During the first year there may need adjustments in the dose and after that you may need to add 100 mg after say 7 or 8 years

[Joolsg]

There have been a few reports of this. But it's rare. Most patients do not develop tolerance.

[magarlick]

With me it stopped working after a few months on 1200mg. Upped to 1800mg and still not working. Am about to start Pregabalin instead.

[Guitarpickin]

I don’t mean to challenge people’s personal experience or expertise but want to say my neurologist told me we do build a tolerance to gabapentin and it’s permanent (meaning taking a break from it will not rectify the situation or enhance our sensitivity to it). I asked when it was first being prescribed and remember because the answer bummed me out. It would be good news if he was wrong!

[purple-flowers]

I took Gabapentin for about a year gradually upping the dose to 1800 mg but it stopped working. I had to taper down very gradually and am now on 5mg Oxycodon in the morning and 10mg in the evening. Unfortunately my RLS is very severe. I have been through all the usual drugs but have found they all stop working after a time. The Oxycodon allows me to sleep at night which is a blessing as I was walking around for hours every night for months. Since I have been on the Oxycodon I get a nights sleep! Hallelujah!!!