RLS for 50 years

[Arizonajan]

I have suffered so nice my 20s. Mildly then last 5 years terrible. Just as others have stated, walked around all nite then have to function and work. Have tried it all. Did go to movement disorder clinic at Mayo in Phoenix and that was no help: have tried it all. Pamiprexole worked, but was losing my hair after 4 years and gained 40 lbs on my small frame.

Now this worked for me from suggestions in this site. Tramadol 50 about 7-730 pm, then another at 1000 1030. Excellent: slept thru nite. Woke up feeling good and not groggy.

jan. Nurse practitioner

[SueJohnson]

That's great. So pleased for you.

[Arizonajan]

perhaps it will help someone else.

[DesertOasis]

Tramadol went up about 100 points in the last few months…in “my” book. It’s not just an opiate, it’s also an antidepressant. Which means that while the opiate is relieving the symptoms of RLS the SNRI portion of Tramadol “may” actually be up-regulating our dopamine receptors. See, read here: researchgate.net/publicatio...

Here’s a quote from the article:

“Repeated administration of tramadol (20 mg/kg i.p. for 21 days) enhanced the d-amphetamine-induced locomotor hyperactivity and increased the density of alpha(1)-adrenoceptors in the rat brain cortex, as measured by saturation analysis of [(3)H]prazosin binding. Autoradiographic analysis of [(3)H]7-OH-DPAT and [(3)H]raclopride binding revealed a significant up-regulation of dopamine D2 and D3 receptors in the rat nucleus accumbens upon repeated treatment with tramadol. All the above-mentioned effects induced by repeated administration of tramadol resemble the effects induced by conventional antidepressants.“

Lab rats should be jumping for joy!!!

We with RLS soooo need to up-regulate our d2/d3 receptors. Or at least not down-regulate them further. That there’s actually a somewhat weak opiate out there that has the potential to relieve RLS symptoms and up-regulate receptors at the same time, is nothing less than a gift from above.

Some people, but definitely not all, develop a tolerance to the opiate portion of Tramadol and then are left with the dopamine receptor blocking portion of it. At that point it might be time to switch to codeine at night and magnesium glycinate by day. Magnesium may also up-regulate our receptors, but in a much less painful and shorter acting way than an antidepressant and then the codeine, of course, should relieve the symptoms of RLS

In a perfect world, we would all eventually be able to come off the opiates and only take ferrous bisglycinate by night and magnesium by day 🌈💥💯