What antidepressant agravates rls - Restless Legs Syn...

Restless Legs Syndrome

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What antidepressant agravates rls

alemaprls profile image
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I've been put on Fluoxetine for anxiety but I'm wondering if it is making my rls worse. Is there another one would be better.

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alemaprls
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Joolsg profile image
Joolsg

All SSRI, SNRI and tricyclical anti depressants worsen RLS.In the UK, they have stopped production of Bupropion, so the only safe option is now trazodone.

For anxiety, rather than depression, a benzodiazepene might be bettef for you and they do not worsen RLS.

Alternatively, a small dose of pregabalin or gabapentin can have a sedating, anti anxiety effect and they're both used to treat RLS.

Here's the list of medications. Scroll down to medications that worsen RLS.

rls-uk.org/medical-treatments

SueJohnson profile image
SueJohnson

Trazodone is safe as Joolsg said. It also treats anxiety and insomnia.

SueJohnson profile image
SueJohnson

Is your RLS under control with your codeine?

alemaprls profile image
alemaprls

It is under control with codeine if I get a flare up but dont like taking it. It now can effect my arms as well as legs. Thank you for the advice, maybe will ask doctor for small dose of Pregabalin instead of Fluoxetine or Trazodone, will see what he says.

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