Husband is taking 10mg Oxycodone at night with 100mg Pregablin
Also 5mg 3 x a day and 100mg Pregablin in morning.
Oxycodone seems to have stopped working and RLS is back at night.
Daughters wedding next week and seriously looking like we will not make it.
Any ideas on what else we can do, bearing in mind we cannot get Buprenorphine in our health authority.
TIA
I know your GP cannot prescribe it, but is there a neurologist or sleep clinic ( or even an addiction clinic!) near you? If you could see another hospital neurologist on an urgent basis and hand over all the evidence for the benefits of Buprenorphine ( and that it worked last time) you may get a better result.Sleep and drug addiction clinics will be able to prescribe Buprenorphine and continue the prescription in your health area.
You shouldn't have to move house to be treated properly, compassionately and effectively.
This happened to me a while back.
I thought I had developed tolerance to the oxy.
However-- when I analysed what changes I had made in my medication routine, I discovered that I had stopped my antihistamine (cetrizine) I was suffering withdrawal from the Cetrizine. Went back on it and everything was hunky dory.
So- what I am pointing out, is that it is highly unlikely that your oxy is not working, but rather something else that has changed.
So look at your recent diet or medicine history and see whatight have changed.
Msg is a huge factor in triggers.
It is included in virtually all commercial stocks and gravy.
Yeast extract is msg. Go figure that one.
Good luck.
Thank you. I have been through everything. He has all fresh food, no salt, sugar or sauces. Very bland diet. Only change has been 25mg reduction in Pregablin as requested by neuro.
I don't know enough about the dosing for Pregabalin, but I imagine that's your cause.
Certainly, for the sake of your upcoming social event, if it were me, I would go back to your original Pregabalin dose, until after the wedding.
Meanwhile, you can research what is a safe dose by which to reduce the Pregabalin.
My gut feeling 25% is much too fast.
Generally 5 % reduction per week would be acceptable for most meds.
Good luck and enjoy that wedding.
great advice here. Hope you make the wedding!
While I don't want to push anyone towards more medication I believe you are taking 200mg pregabalin a day and the maximum dose normally recommended (in Mayo Algorithm) is 300mg so you might not actually be taking enough and it's possible that your recent reduction may be the cause of a change in symptoms as Madlegs suggests.
There are many reasons you might want to reduce pregabalin such as side effects, lack of efficacy, or just personal preference but at the moment going back up to the previous level will tell you something about your recent change, (i.e. was it the cause?) and may help you be at your daughters' wedding.
Having taken pregabalin and come off it I didn't find it difficult or experience any side effects, the main feeling was nervousness about how I might feel, but I'd certainly recommend taking it slowly. I dropped by 75mg every couple of weeks or so.
I agree with the comments here to go back up on your pregabalin. If that doesn't work, you might want to try increasing the dose of Oxycodone at night. According to the Mayo Clinic Algorithm, 10 to 30 mg is the usual effective dose. You didn't say his RLS was back during the daytime so if that is the case it still is working.
Hi Sue, the Oxy he is taking during the day is controlling the daytime RLS, so just the night now. Last night he had 3hrs sleep then RLS woke him, but after 1hr hr got a bit more sleep. Going to see what happens after going back up on Pregablin.
Oxycodone Dopamine Agonist? 
Tramadol and oxycodone
