Pregabalin fatigue: For what it is... - Restless Legs Syn...

Restless Legs Syndrome

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Pregabalin fatigue

wantokporo profile image
10 Replies

For what it is worth, my primary care doctor said the daytime sedation after years on 150 mg. of Pregabalin could, unfortunately, be the medicine. Thyroid tests came out normal.

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wantokporo profile image
wantokporo
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10 Replies
SueJohnson profile image
SueJohnson

Yes - that can be a side effect of pregabalin.

LotteM profile image
LotteM

Difficult to accept and deal with. I can relate. I have the samen on buprenorphine, even at a low dose. Acceptance and stay within limits. But it continues to feel unfair, as not all get it. It it is also not uncommon.

Yes, that's what my sleep specialist and general physician have suggested is the cause of my daytime fatigue (exacerbated when I take clonazepam).

I'm linking something I posted a while back

healthunlocked.com/rlsuk/po...

Nikos64 profile image
Nikos64

I was also on 150mg of pregabalin and also experienced severe fatigue. Not only that, it made waking up extremely difficult and I missed work on a few occasions. Since it was interfering with work I asked to be taken off it. Watch out for the weight gain too!

Medici profile image
Medici in reply toNikos64

Have you stopped it now and if so has the weight gain reduced please?

wantokporo profile image
wantokporo in reply toMedici

No I didn't stop it because -- on balance -- my life is better despite the sedation. I didn't have the weight gain side effect. I have tried SOOO many other things.

Medici profile image
Medici in reply towantokporo

Thank you. I know the feeling.

Nikos64 profile image
Nikos64 in reply toMedici

I stopped it. The sedation was unacceptable. The weight gain slowly went away after a few months. I did not think this medication was right for me.

Medici profile image
Medici in reply toNikos64

Thank you Nikos. How was your RLS when you stopped and what do you take now?

Nikos64 profile image
Nikos64 in reply toMedici

I was on 50mg of Tramadol and 150mg pregabalin. The doctor simply replaced the pregabalin with an extra 50mg of Tramadol. This worked quite well. Lately the RLS has gotten worse and the doctor added Horizant. RLS has been my tormentor since childhood. It got worse after I turned 50 which is when I sought professional help. Best wishes in finding an effective medication through your doctor!

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