Fycompa

[LanaCSR]

Does anyone know if this medicine causes augmentation?

[Madlegs1]

This is quite a new type of drug.

It has been successful in alleviating rls symptoms.

It is probably too early to know whether it will cause augmentation.

A pharmacist might be better able to make a judgement on that based on its chemistry.

Good luck with it if you decide to go ahead.

It might be worthwhile writing to the manufacturers, although I'm imagining, from the reviews, that you will need to have fairly good French.

Cheers.😎

[LotteM]

Ah, fycompa is perampanel. The study on this med for RLS was done and published by Garcia-Borreguero et al in 2017. In the paper, they give no rationale of why they chose perampanel. It is a med "that has been approved for the treatment of partial seizures". And it is a selective glutamate-receptor antagonist. Antagonists block the receptors and thereby prohibits its functioning (as long as the antagonist is bound to the receptor). Glutamate is a neurotransmitter. In RLS we have increased 'presynaptic' glutamate. Presynaptic is the end of a nerve cell (neuron) before the neurotransmitters inside that neuron get transmitted to the next neuron. There, in the 'receiving' neuron the neurotransmitters will be postsynaptic.

Oops, a short lecture. Sorry about that. I have been reading too many papers recently. Anyway, this is the only study/paper about perampanel so far. And Dr Buchfuhrer (rlshelp.org) doesn't mention perampanel on hos treatment page or in his response letters.