Although I like to do research on symptoms, causes, etc., I usually don't get paranoid about what I find. Within the last 3 or 4 years I noticed my toes colored blue to near black a lot. Just tonight I could not get warm and my remedy for that is to get into a hot tub. Such relief! Anyway, again, black toes, but this time the tops of my knees were also discolored. I tried some research and the closest thing I found came down to peripheral artery disease. Yes I could stand to lose 20 or 30 pounds. Once I was diagnosed as hypothyroid I was hoping my change in meds might help some there. I too have RLS, and sometimes severe cramping in my toes. I have regular blood labs done. No diabetes, no high cholesterol, although I do have high blood pressure. Also I am not the most sedentary person. If I do a job requiring more sitting than I should be doing in a day, I always have to go outside and walk, and in the summer I swim in the pool everyday. I was wondering if the fact that when I have blood drawn for labs, and also at times when I have a procedure done requiring an IV, medical professionals cannot get my veins without sticking me numerous times, and then they usually have to resort to using the tiniest needles and go really slow. Could my experience with these labs and IV's be telling as to a major problem with my arteries, besides the color I am experiencing? Anyone who has an input would be appreciated.