Well, I started out on 2.5 mg of methadone twice a day and didn't notice any difference. I'm currently at 5 mg twice a day and still nothing. I'm supposed to check in with the Dr tomorrow. I assume he'll want to go up to 10 mg twice a day, but I'm not sure if that's a good idea. How high is it safe to go up to on the medicine? How high should we go before giving up on it? I really didn't think 2.5 mg would do anything, but I had a really good feeling about 5 mg... so I'm pretty bummed out right now.