Results that align with recent research showing energy production dysfunction at a cellular level bmcmedgenomics.biomedcentra...
More cellular metabolism: Results that align... - Ramsays Disease
More cellular metabolism
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from huff post huffingtonpost.com.au/2017/...
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It seems that cells in chronic fatigue syndrome switch to an inefficient supply.
This was reported by New Scientist magazine last week on the basis of international research.
Chronic fatigue syndrome, now commonly referred to as myalgic encephalomyelitis (ME / CFS) is characterized by persistent physical and mental fatigue that does not improve with sleep or to do calmer. Medici can not agree on whether the disease has a physical cause of the disease is between the ears.
Examination of various departments now gives the impression that the sugar combustion process which provides body cells with energy, not work well in patients with ME. "It seems that people with CFS / ME is no longer, as usual, get their energy from sugar, but switch to less efficient combustion of amino acids and fats." Those alternative combustion is acid free, what if the substance causes pain itself accumulates in the muscles. "These abnormal sugar combustion can both explain the fatigue and the fact that moderate exercise has been exhausting and can cause sore muscles."
A Norwegian research group led by Oystein Fluge was interesting railway male-female difference after a study involving 200 people with ME / CFS and 102 healthy individuals. The blood levels of certain amino acids were found in women with CFS / ME to be particularly low, especially the values of amino acids that the body can use as an alternative energy source.
In men with ME / CFS which were not low values. "Men get amino acids for energy rather than their muscles in their blood," the researchers explain that difference. An amino acid that proved indicative of this process is indeed elevated in ME-men. "It seems that both men and women with ME / CFS have a problem with the conversion of sugars into energy, but they compensate in different ways," said Fluge.
Starvation
The enzyme pyruvate dehydrogenase (PDH) plays an important role in this story: the protein transports carbohydrates and sugars from the cytoplasm in the mitochondria. Mitochondria are the energy factories of the cell and the place where the sugar burning. "At CFS patients, both men and women, appear enzymes increased suppress the activity of PDH." The inhibition may cause your sugars that patients can use right for their energy supply.
The Australian researcher Chris Armstrong, at the University of Melbourne, believes that the problem lies not only in the PDH enzyme, but in the whole chain of the sugar burning. He compares it to starvation. "When people are starving, switching most body cells over the burning of amino acids and fatty acids, so as much sugar is left for combustion in the brains and muscles."
In recent years several studies have established a link between ME / CFS and sugar burning. But how this problem arises, is still unclear. Several researchers think that a (mild) infection triggers changes, but they can not figure out exactly how this leads to ME / CFS.
The Norwegian research group, or have already shown that suppression of antibody-producing immune cells may reduce the symptoms. Fluge suspects that antibodies that the body has created in response to an infection, can have as a side effect that they switch off the body's PDH enzyme.
To examine this hypothesis, the department carries out a study in which the antibody producing cells of CFS patients are disabled by the anti-cancer agent rituximab. Next year, the results of this study will be known.
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Identifying different phenotypes and the treatments most beneficial rather than one size fits all would be a major step forward . Identifying responders within the Rituximab trial has also produced distinct sub groups within the main Canadian Consensus Criteria research cohort.
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