I have had RA for 6 years. Initially, my symptoms were quite problematic. I had fatigue low grade fevers, achy swollen hands and quickly some joint damage and deformity. When a rheumatologist was suggested, I finally got lucky. I was put on methotrexate and folic acid as well as lots and lots of Advil. I began to feel much better after 2 months. My rheumatologist was still not happy with how my hands looked so Embrel was added. I then went off Enbril and added Humira. I did well for several years on this protocol. Last winter I had a sinus infection that just would not quit even with two rounds of antibiotic. I took no medication for 2 months. Once the infection cleared I went back to Humira only. My rheumatologist said I could stop the Methotrexate, which I did. Soon I got a little flare with soreness in my legs feet and sometimes hands. I guess that 5 months off Methotrexate is all I can do. I have now gone back on a very low dose of Methotrexate which I hate due to side effects of hives and night sweats. Despite my recent problems I am still able to work part time and volunteer in our community. I am probably one of the luckier ones with RA.