Decipher GRID

[JRLDH]

I was wondering if people here have experience with Decipher GRID genomic atlas.

My Decipher score is low risk but the Decipher GRID genomic atlas shows >90 percentile “small cell like” and Neuroendocrine Gene/Signature are highlighted with DXC, MYCN red in the 99 percentile and SCG2 and SYP at 90.

I haven’t heard from the Oncologist yet (holidays) but am a bit worried about this apparent contradiction low risk score vs. GRID genomic atlas showing a Neuroendocrine Small Cell like bias.

Not sure how to use this “research use only” GRID info being on Active Surveillance ?!

[Xavier10]

doesn't make sense, does it? Low risk yet neuroendocrine risks. What was the overall score? Probably going to have to have Decipher explain that one.

[JRLDH in reply to Xavier10]

The overall score was 0.18 so my first reaction was a huge relief but then all the “bad” genes are in the Neuroendocrine category so now I am confused.

It “feels” like the common adenocarcinoma gene percentiles are fine/low risk but I seem to be one mutation away from a small cell cancer threat and I’m not sure if that figures into the score.

The spider web genomic atlas in the GRID “research use only” is almost maxed out in the Neuroendocrine direction and looks like it’s immune suppressed.

Genomic Atlas spider web diagram

[Xavier10 in reply to JRLDH]

i think i would stick with the low score relief. I had a DECIPHER done and it came back .39 and that supposedly is low but now I am thinking I would like to see it redone with that GRID. Or wait, maybe I shouldn't.

[OldTiredSailor]

I am currently 76-months past my prostate removal. I had a GRID analysis done on the tumor tissue a month after the surgery. It told me (among other findings) that my tumor would be very sensitive to radiation therapy and not at all sensitive to Docetaxel therapy.

My Decipher score was 0.47. Now, my PSA has increased to 0.4 after being undetectable for almost six-years.

My oncologist and radiation doc (Moffitt Cancer Center) both tell me to ignore anything that Decipher and/or GRID told me because "the genetics of tumor could easily have changed during the last six-years and that may be why the PSA suddenly doubled and redoubled in the last 18-months." They were/are emphatic that the post-surgery Decipher info is of no value now.

Seems puzzling to me!

[Mgtd]

Perhaps there is some value in knowing why the test grid is labeled “RESEARCH”. Maybe it was not to be used for diagnostic work.

Just a thought.

[JRLDH in reply to Mgtd]

I'm not using it for diagnosis. I'm using it for research. I'm researching opinions. Maybe someone on this forum has experience with it?

For example, if you had this GRID info about your cancer, would you try figuring out what it means or would you just toss it aside as unimportant because it's just meant for researchers?

[LiveLongAndPropser]

As Mgtd points out, Decipher data is also used for research purposes. For example, they may track data for specific studies and provide that data on your report for medical facilities participating in those studies to review. Researchers could see that data and be able to follow up on your outcomes, provided that you gave consent for your genomic data to be available for research. It's because of this tracked data that they are able to identify trends for what is expressed by the various markers on our genes for diagnostic and procedural guidance. Decipher's focus is primarily prostate and urinary-related research, but I suspect they are expanding their research to new areas. That's a very high-level, simplified explanation, but maybe helps? I know it doesn't necessarily give you any details on what it means though. As I always add, your providers should be able to give you more detailed and specific feedback about what any of this data means for you specifically.