additional comments on second pathology

[Granolaberry]

Hello,

I just received additional comments on second opinion surgical pathology. I was wondering if you can provide feedback because I don’t understand. I am seeing PA on Friday so I need to ask the right questions. Please help me understand this. I have Gleason 3+4 (40% 4) plus intraductal. Negative margins, No ECE, clear lymph nodes, No LVI and no SVI. However additional comments…

The submitted immunohistochemical stains show that tumor is diffusely positive for ERG. PTEN expression is variably lost in the tumor, with the loss of expression more pronounced in intraductal component and cribriform carcinoma. Immunohistochemical stain PIN4 helps distinguish the presence of high grade PIN, intraductal component, and invasive tumor. All controls are appropriate. Benign glands are focally present at margins

[FMOH_N]

Is the genetic test performed on tumor? have you had any other form of genetic testing, not on the tumor? What genetic tests are recommended? Has Intraductal and/or cribriform morphology any association with mutations or other genetic failure? what additional treatment is recommended/required? is it enough to only monitor the PSA? Have you done any PSMA-PET or is this recommended? was it 20% or 40% of pattern 4? In your case the cancer is organ confined, so what is the chance for spread?

[Murk]

IMO, I would pause, look him/her right in the eye and say I'm not leaving until you slowly explain the results using laymen language and what is htier vision of the next two to three steps ahead...

[davcarv]

copy paste into chat GPT and tell it to reply in laymens terms.

Does a great job.

Confirmed accuracy of the responce with dr.

Whats cool is it’s not perfect and you can challenge the response and it’ll clarify

[Darryl Partner]

use Cancer Copilot on Malecare.org