The importance of radiotherapy dose escalation and long-term ADT for success

[Tall_Allen]

Both increase "cure rates" in high risk and intermediate risk patients (at least "unfavorable intermediate risk" patients).

prostatecancer.news/2022/04...

[cesces]

Very very very nice blog article.

Synthesizing a lot of information into simple and actionable data.

[Scout4answers in reply to cesces]

What conclusion do you reach or what action will you now take?

[cesces in reply to Scout4answers]

Not currently under treatment.

But reinforces the statistical research that says hit it with everything hard at once.

It doesn't change my thoughts on your situation... as to thinking long and hard about when to use your singular Sbrt bullet.

Does that make sense to you?

[Scout4answers in reply to cesces]

RO (Same guy who did the study TA quotes) said it is actually possible to use SBRT more than once now. Leaving aside for the moment how much total radiation the human body can withstand.

His study says that total time on ADT is only beneficial after radiation. While it may be helpful to be on ADT before radiation to shrink size of prostate and tumor, the LT benefit is from time on ADT following rad. As you know I do not want to be on ADT one more day than is absolutely necessary because of what lack of T is doing to my body.

Still waiting on results of his proprietary genetic test to find out if I am eligible for SBRT.

[CAMPSOUPS in reply to cesces]

Yes! As we know that's who he is and what he's about.I have a hard time imagining what this journey would be like without his dedication and intelligence in messaging.

[Fiddler2004]

Thanks for sharing your informative post.

[ragnar2020]

TA, As usual, this is another clearly organized and skillfully written presentation. Nicely done. Thanks.

[45yrsDenmark]

Great review !! Do you know if studies exist or are on their way with younger men as target group? Sometimes I wonder if the results from studies would differ when/if conducted on men within a range of age I can better relate myself to.....

[Tall_Allen in reply to 45yrsDenmark]

Unfortunately for you, men who opt for radiation tend to be older. I hope this will change. But clinical trials reflect the age range of the patients opting for that therapy.

[Cooolone]

Yes, thank you for posting!

[CAMPSOUPS]

Cant thank you enough. Another evidence reference compiled and easily reached on your site.It will be there for my brother (on AS) if he ever needs consultation (hope he stays AS of course though).

[conbio]

Thanks TA - good article that also condenses terms I've seen but not fully understood

[northshoreguy]

If I could piggyback off this question.Gleason 4+3, RP followed by BCR 5 months later. Treated with sbrt for one tumor in my pelvic area plus 9 months of Lupton / Eligard then 12 months of orgovyx. MO planned to stop adt at the end of June but it has taken a toll on me physically and emotionally. I would like to stop adt now. I'd like some opinions weather stopping 2 months early would carry unwanted consequences. BTW my psa has been undetectable since the first shot of Lupron. May thanks for the great advice and info from my brothers

[Tall_Allen in reply to northshoreguy]

northshoreguy - I suggest you post this on the advanced PC forum as a new thread:

healthunlocked.com/advanced...

I think you will get many more replies if you do.

You are metastatic. The SOC is lifelong ADT, but occasional vacations can be taken if needed.

[northshoreguy in reply to Tall_Allen]

Thank you TA

[Nous]

thanks for sharing this Tall_Allen

[KAgolf]

TA, very interesting and hopeful article--thanks for postingwhen they mention "localized", does that include regional localized where 3-4 lymph nodes were suspicious and considered positive? Or do they mean only prostate is involved, nothing else?

thanks

[Tall_Allen]

Localized means prostate only.

[Hidden]

Go! Long term adt! Whoohoo 7 years on it for me!😳