Advice on treatment and Brca2

[TTST]

Seeking advice

60 yr good health with controlled hypertension. Elevated PSA of 4.7 asymptomatic lead to a TRUS biopsy.

PSA currently at 3.1

PCa in three of the twelve cores3+3 in two cores and 3+4 in 1mm of one core. Gleason 7

Stage T1c. Diagnosed 6/21. Was considering a bit of AS however due to a very stron family history of brca gene had the genetic test done s as nd found out I’m Brca2 in January this year.

One of my big questions is exactly how does the Brca2 play a part in the diagnosis and does it point my treatment options more on a specific direction. I meeting with radiation onocologist and surgeon this week coming.

Please let me know if you need more information, it’s my first time posting anywhere. Thanks

[Tall_Allen]

BRCA+ probably means that active surveillance wouldn't last long. But other than that, your diagnosis as "favorable intermediate risk" means that any of the ordinary treatments should be curative. By ordinary treatments, I mean: surgery, Brachytherapy, or SBRT. They all have a 90+% chance of curing you. At the end of this article are some questions you may want to ask those specialists:

prostatecancer.news/2017/12...

Also, it's a good idea to get Jonathan Epstein's second opinion of your biopsy slides:

pathology.jhu.edu/patient-c...

[HopingForTheBest1]

Also BRCA2. I have a much more aggressive case than you, and have been dealing with this Gleason 10 diagnosis for almost 4 years. See my profile for details.

Use of Olaparib PARP kept my PSA as undetectable for close to 2 years before it ran it's course.

As you have BRCA2, make sure that your adult siblings and children, both male and female, also get checked. It could save their lives.