Perioperative beta blockers and PC recurrence

[dentaltwin]

Don't know if this has been discussed--this just crossed my desk. Non-selective beta-blockers at time of radical prostatectomy was associated with a lower risk of recurrence. Frankly, sounds far-fetched to me:

jamanetwork.com/journals/ja...

[Tall_Allen]

I share your skepticism. It was just a retrospective study. Other retrospective studies show added risk or no effect:

wjso.biomedcentral.com/arti...

sciencedirect.com/science/a...

bjanaesthesia.org/article/S...

ejcancer.com/article/S0959-...

The justification is that nerves innervate tumors and their signals are needed for tumor growth. There is a prospective clinical trial:

clinicaltrials.gov/ct2/show...

[dentaltwin in reply to Tall_Allen]

Really inspires confidence, doesn't it?