Perioperative beta blockers and PC re... - Prostate Cancer N...

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Perioperative beta blockers and PC recurrence

dentaltwin profile image
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Don't know if this has been discussed--this just crossed my desk. Non-selective beta-blockers at time of radical prostatectomy was associated with a lower risk of recurrence. Frankly, sounds far-fetched to me:

jamanetwork.com/journals/ja...

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dentaltwin
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Tall_Allen profile image
Tall_Allen

I share your skepticism. It was just a retrospective study. Other retrospective studies show added risk or no effect:

wjso.biomedcentral.com/arti...

sciencedirect.com/science/a...

bjanaesthesia.org/article/S...

ejcancer.com/article/S0959-...

The justification is that nerves innervate tumors and their signals are needed for tumor growth. There is a prospective clinical trial:

clinicaltrials.gov/ct2/show...

dentaltwin profile image
dentaltwin in reply toTall_Allen

Really inspires confidence, doesn't it?

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