Does Hypothalamic Hypogonadism pre-diagnosis affect disease course?

[mperloe]

Would a low T prior to diagnosis suggest a more rapid progression to castrate resistance? If so, is that risk reduced if T was normalize with T replacement at the time diagnosis was made?

[Tall_Allen]

Hypogonadism is a marker for more aggressive PCa:

pubmed.ncbi.nlm.nih.gov/214...

But I don't know if that means CR is reached faster.

I also don't know if TRT at the time of diagnosis will reverse it. My guess is that the chronicly low levels of T over years contributed to genomic damage. I doubt if that can be fixed so quickly.

BAT might be useful in metastatic men who are hormone sensitive, but those results are very preliminary:

prostatecancer.news/2016/09...

[Hidden]

I took a low dose of Androgel for six years before quitting three years before I was dx with PCa. I always wondered if maybe i should have kept taking it.