methotrexate pill vs injection?

[Heidiypi1]

im now starting the methox injection on Monday as the pills were horrendous for me I can’t live with those side affects, it feels like im poisoning my body! So has anyone here ever had a different reaction experience on the methotrexate injections vs the pills? Im on 10mgs once a week.

btw my rhumy said he believes the reaction would be the same.. ie really awful diarrhea, totally fatigued like scraping myself off the floor type thing - completely useless, humungous foggy and pressurised head, stabbing erratic knives in the temples etc!

I would appreciate your good opinions!

[DorsetLady PMRGCAuk volunteer]

No personal experience of MTX but there’s a lot of info in the FAQs- see link here’s-

healthunlocked.com/pmrgcauk...

Now you have posted there are related posts - either on right of screen or scroll down to below current posts [depends which device you are using].

[PMRpro Ambassador]

There are related posts about injections that may be interesting.

But really the only way to find out is to try it and see how it works for you. Just because someone else had a particular experience doesn't mean you will too. MTX jabs seem to improve the gastric/GI effects and that is the main reason for trying them. The fatigue is a component of the medication for some - it was the reason I stopped MTX, as a sole carer I had to be able to function. MTX also introduced or magnified effects that are usually blamed on pred but which I had never had before,

[Heidiypi1]

after much thought and reading researching Methotx I decided not to start the injections of this as I had such severe reactions to the two tablets I had taken. So instead I am now only on 5mgs Prednisone a day I will reduce it by 1/2 a mg soon, but I think I would prefer to just stay on this, awaiting what my Rhumy says, hopefully he will support my decision!..

Some of the reasons for my decision is I am extremely sensitive as I have CLL and have now contracted 3 autoimmune diseases since starting the covid vaccines which I’ve had 5 and I will never have another! So it seems if there is something that I could possibly contract from some medication it will most likely be me, so I am not going to take anymore chances!

[PMRpro Ambassador in reply to Heidiypi1]

If you are only on 5mg anyway there is no real point in you trying MTX. Is that the dose you were at when the doctor introduced the MTX? Most experts would not add MTX if you are well below 10mg pred.

[Heidiypi1]

I was on 4mgs but started to flare really badly, so I went to 6mgs and my rhumy does not want me over 5mgs as the ramifications are not good long term. I speak to him next week see what he says, he does give me good sound advise, but I’m wary of Methotrexate now…