PMRGCAuk
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Prednisilone side effects

Hi,

i am suffering from SLE since 4 years and i am taking prednisone. I want to know, Is that ok to taking prednisilone tablets at night. And is there any worst effects taking prednisilone in night than morning

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Insomnia can be a side effect of Pred and all the advice suggests that you should take it early in the morning.

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Thank you. Can I take prednisilone to night????

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You can take it whenever suits you. If you are on a high dose you may find that it interfere's with your sleep. I have taken it it in the early hours to stave off morning pain and stiffness and got back to sleep no bother.

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Hi ayomi

You might be better in sle forum as this one is for pmr/GCA. We do have commonality in pred as treatment. I would think that you need to investigate whether you are on coated or Uncoated pred. The coated takes a while to work and is commonly taken at night and starts to work once coating dissolved so after sleep hopefully.

Don't if if this helps as I don't know enough about sle. Good luck!!

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thank you

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Thank you

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Hi ayomi.

A study done some years ago showed that taking 5mg of pred at night caused more adrenal suppression than taking 15mg in the morning. So since then doctors have been fixated that you shouldn't take pred at night. If you are on a short course of pred, say just a couple of weeks, then it is very helpful to just take the pred in the morning so there is less adrenal suppression to worry about when you stop taking it. Lots of people also think it is less likely to affect sleep.

However, when you take pred over a long period or at a high dose there is likely to be adrenal suppression anyway and so it makes far more sense to take it at the time that works best for YOU. And if that is at night - there is no real reason not to. Several people on this forum take or have taken their pred at night and it has avoided various side effects that bothered them and it didn't affect their sleep. The other side effects are likely to be similar.

It also depends why you are using it in your SLE - lots of us find taking our pred at night/very early morning makes our morning stiffness in PMR which we all have here. So it really is a case of what times leaves you feeling better for what you take it for.

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Thank you so much.. In my experience, when i take pred at night, i feel better in the morning. But the only problem i have, whether it will badly affect for my kidneys.

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Your renal specialist is the person to ask there - but I don't see why it should as pred is used in a lot of kidney disease - and if you are taking it, I doubt WHEN you take it makes any differene. Take it when it works for you .

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Ayomi. Lots of helpful replies for you here giving you much more advice than I could. I have only ever taken it in the morning and only been on it 2 months. I’m a newby. 😊😊

Good luck.

Pym

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When I took pred in the morning it seemed to take two or three hours to "kick in" so I started taking it at night and then I felt much better when I woke up. No problem sleeping as I'm usually totally knackered by bed time! Only issue is that by bed time the pred effect seems to wear off a bit so I don't feel quite as good. But I prefer going to bed feeling less than 100% than going to work under par!

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Sorry, I do not know the answer to that question. I take it in the early AM. It has helped me with my lung disease.

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