Having just gone through my worst flare of my 15 months of actively dealing with GCA and PMR......I've ended up spending most of my time in bed with time to think.
Hubby and I have done some posting about our decision to split my daily dosage ( 18mg ) to relieve some of my morning PMR pain. For three days, that was what we did and it seemed to be working. In the meantime, I had ordered enteric coated capsules....knowing I could take my 5mg at an early bedtime and have it absorbed at a more suitable time. Last Wed. evening,....that's what we used and again on Thurs. evening. At midnight, I was on my way to the hospital for a six hour stay and continue to suffer. I was given a 'burst' and on Fri started back to my original 60mg. Although, the split of my dosage may have been unwise....I, now, believe there could have been another problem. My new theory....I was using an enteric capsule with what I believe was a (5mg) enteric coated tablet. Dealing with chronic IBS, I generally have Questran, Imodium and Pepto Bismol in my system. I'm guessing they could have changed the ph needed to break down the coating. Again, I'm guessing, that 10mg of pred may have just passed through.
Enteric capsules are a great idea.....but, maybe, not always.
Would love to hear other's opinions. And more importantly, caution others to think twice about using the capsules. Would, certainly, hate to see anyone else go through the, perhaps preventable, misery.