Hi I am writing on behalf of my mum, who is 73 years of age and was diagnosed with PMR nearly 4 years ago. Mum has had a number of flare ups of PMR, where her predisolene dosage has been increased on a number of occasions. She attends a Rhematology Clinic every 6 months and is currently on 4mg, reducing to 4mg/3mg alternate days for one month from the 1st July. She is due back Sept'13. Over the last two weeks, she has been experiencing pain down her legs/knee area. The pain appears to be associated with mainly her left side. Is this common with other PMR sufferers where the pain appears to be associated with one side? Due to the pain she is currently experiencing we have made contact with the Rhematologist nurse and they have arranged to see my mum on Thursday. At her last visit with the Rhematologist, my mum was given a leaftlet on Methotrexate and this medication could be an option if mum was having difficulty reducing her steroids. The leaflet described minor side affects, however on researching this medication I was alarmed to read about the "life threatening side affects". I have read some of the blogs on your website on Methotrexate, if anyone has any further information on this medication, this would be greatly appreciated.