This work was done by a physicist. The scientist who work for the pharmaceutical companies will likely be aware of it and incorporate it into their work. . Like it or not scientists who work for the pharmaceutical are Premier League.
It may take a while if ever that action is taken utilizing this discovery leading to better B12 treatment and testing. Or it might not be important in this regards. Only time will tell.
If this were my field I would know who to send the information to.
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WIZARD6787
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It looks very incomplete, but the probiotic or bacteria they are referring to is Bacteroides in the intestines which they are saying uptakes b12. It comes up on a search on Amazon. Interesting thank you for sharing.
OK. Had a quick browse of this very dense paper. It's investigating how a particular genus of gut bacteria called "Bacteroides" manage to get the B12 that they need to survive. They cannot synthesize B12 themselves (only some micororganisms can) and so need to scavenge it somehow.
The image at the end of the paper and shown at the phys.org site shows the nitty gritty details of how B12 uptake by this bacteria works.
This has no direct relevance to the Haptocorrin/IF-mediated absorption of B12 in which B12 is normally absorbed from the diet. Completely separate pathway.
There is this interesting section though:
"Interestingly, BtuG2 is a surface-exposed OM lipoprotein with an extremely high affinity for B12 (sub-pM) and is able to remove the vitamin from human intrinsic factor (IF), which binds B12 in the small intestine prior to absorption"
The psy.org article contains this paragraph:
"Kleinekathöfer and his team's breakthrough finding, what they call "pedal-bin mechanisms," offers critical understanding for how bacteria in the intestine known as bacteroides can absorb vitamin B12. This is important for human health since B12 cannot be produced or absorbed by humans themselves. "
This is incorrect as humans CAN absorb B12 via our 2 transport proteins (haptocorrin + intrinsic factor). Nothing about the mechanism investigated here is relevant to the haptocorrin/IF-mediated absorption of B12. Rather this mechanism is how these particular gut bacteria get enough B12 to thrive. This is important for human health in the sense that our gut needs healthy bacteria (they need to get their B12 too!) but the B12 that they absorb is not absorbed into our circulation and does not become metabolically useful B12 for us. The gut bacteria just use it to thrive themselves.
So its indirectly useful to human health as it allows these good gut beasts to thrive. But they dont give us their B12! Mean little b...... 😆
Thank you for reading that and sharing. I was hoping that it fit well with the current misunderstanding of how the human body functions. Maybe it will lead to something valuable.
My skin has goosebumps. Just a hint of Quantum has this effect. On a hospital ward, staff would misinterpret my, Don’t mention the Q word as Quiet.
So, I would burst into song being Erik from Phantom of the Opera, My power over you grows stronger yet. Then, Sing my angels, sing for me.
Absolutely clueless that I was talking about numbers, time, space, the phases of the moon. One night, I asked everyone, Where have all the mercury thermometers gone then hey ?
In my personal life, I video, streams, rivers and the sea. The dynamics of H2O. I love a vortex or vortices too. Cheap at half the price.
Fascinating! good find 🙂 what I can find online suggests legumes/beans Zoe programme type diet. Which figures because I really struggle to digest those. QED 🌱
Snippet from we search on how to increase bacterioides
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