Parathesia

[Janine60]

Low vitamin B12 in January. 3 months of oral supplements. Bloods completed again results even lower than original results. 6 loading doses of B12 injections. Then injections every three months. Just recently had B12 injection now I’m suffering with pins and needles numbness pretty much everywhere. Palpitations and shakiness and balance issues.

I already have small fibre neuropathy since 2011 which is difficult to manage. With this on top it seems to have increased all my original symptoms.

my neurologist stated it will take a long time for cns to recover if at all.

Does any body else have these problems with B12 injections.

Fed up and frustrated with the whole thing and lack of help going forward.

thanks for listening

[Technoid]

Sounds like the normal symptoms of early treatment decline to me.

Was the "small fibre neuropathy" in 2011 caused by B12 deficiency?

[Janine60 in reply to Technoid]

No my B12 was fine then and has been ok for years. What do you mean by treatment decline ?

[Technoid in reply to Janine60]

Early treatment decline is a phenomenon where symptoms worsen or new symptoms appear in early stages of intensive B12 deficiency treatment. Depending on the severity of damage, this period might be anything from a few weeks to several months.

As the availability of B12 restarts the processes that lead to repair of the myelin sheath protecting nerves, increased pins and needles and even sharp pains may be experienced as sensation returns and the full extent of any damage is conveyed by the repaired nerves.

Per B12 institute:

"Both practical experience and literature on the subject show that sometimes symptoms and complaints get worse after starting the suppletion intake (cf the side effects described above), disappearing after a few days or weeks. This phenomenon cannot be explained entirely from a chemical perspective, but we should certainly refrain from concluding that in these cases B12 deficiency was an incorrect diagnosis. Therefore this phenomenon should not lead to stop treatment after having been diagnosed with symptomatic B12 deficiency. "

b12-institute.nl/en/treatment/

[Technoid in reply to Technoid]

Having a normal B12 (by serum) doesnt mean a deficiency is not present. There is functional deficiency, where B12 is not available to cells. In general serum B12 is not the best guideline and cannot definitively exclude a deficiency. Active B12, MMA and Homocysteine are better markers (particularly MMA), but are not infallible either and require disentangling from other conditions which may affect them.

"although elevated MMA and HCys concentrations may be indicative of vitamin B12 deficiency, normal concentrations of these biomarkers do not rule out deficiency or a favourable response to cobalamin therapy"

from "Association of vitamin B12, methylmalonic acid, and functional parameters"

ref: njmonline.nl/article_ft.php...