Frequency of self injections

[jaybirdxNHM]

jaybirdxNHM

How long is it before the benefit of an IM injection is felt?

I am trying to work out the best time of day to inject and how often , I am finding every 3rd day, so far. I inject 4 o.clock ish! Thank you

[pvanderaa]

I inject first thing in the morning and can feel like superman all day, sometimes too much like superman and I overdo it. I call this the roller coaster ride.

I’ve tried injecting just before bed and then I have tossed and turned all night long.

I also supplement with methyl sublinguals and taking those at bedtime, actually helps me dream better and I get more restful sleep.

What supplements like folic acid and a daily multivitamin, are you taking? I spread my folic acid out through the day and that has stabilized the roller coaster ride.

It really comes down to whatever works for you and your schedule in the week and the day.

Do you keep a logbook of symptoms?

[jaybirdxNHM in reply to pvanderaa]

Thankyou. I take a multivitamin, but also various pain killers due to a form of arthritis. Its sometimes difficult to decide what symptoms are which, but I'm getting better at detective work all the time!!

[IMINHIM in reply to jaybirdxNHM]

are you on PREDNISONE ????? if so how much do you take and how long have you been on it ????? it greatly depletes your b12 levels----and there are serious side effects of the prednisone

Admin note: IMINHIM requested to supply reference as not aware of any interaction between Prednisone and B12.

[jaybirdxNHM in reply to IMINHIM]

No I'm not . Thanks

[fbirder in reply to IMINHIM]

drugs.com/drug-interactions...

There were no interactions found in our database between prednisone and Vitamin B12

[Gambit62 Administrator in reply to IMINHIM]

IMINHIM, do you have a source for saying that prednisone affects vitamin B12 levels. I can find a few articles that suggest corticosteroids (the family of drugs that prednisone belongs to) affect B vitamins but I can't actually find any studies that confirm this. I did find this recent literature review which looked at studies of the effect of long term use of a number of medicines in relation to nutrients.

ncbi.nlm.nih.gov/pmc/articl...

The table at the end of section 1 lists the following as affected by cortico-steroids:

Calcium/Vitamin D; Sodium and Potassium; Chromium

B Vitamins are absent. They are mentioned against other types of drugs mentioned in the list.

This suggests that there may have been some studies that initially suggested that there might be some interferrence with B vitamins but this was later refuted follow on studies.

It is also worth noting that even within a class of drugs some specific drugs may not follow the general trend.

[fbirder]

It shouldn't make any difference. The B12 is absorbed from an intramuscular injection quite slowly. Blood levels take about 2 to 9 hours to reach a maximum level and they drop quite slowly after that. With repeat dosing every 3 days your levels will not change a lot throughout the day.

The correct frequency of IM dosing is - often enough to keep symptoms at bay.

[jaybirdxNHM in reply to fbirder]

Thanks, As I am old(76) ,I have time to play around with time. I will stick with every 3 days and closely monitor.

What a wonderful forum this is !!

[raelenejones in reply to jaybirdxNHM]

You're not old! A mere youngster.

[IMINHIM]

is that 1000 mcg-----and what type of b12 are you using-----and every 3 days-----???? and are you running tests ???? if so with who----or what lab----and what type of test----I understand that a regular blood test is ineffective----the test has to be on a cellular level-----which is a more complicated test----???? thank you---I am just new to all of this but anxious to learn-----thanks again---

[JanD236 in reply to IMINHIM]

IMINHIM once injections have started you are right in thinking that tests for serum B12 are worthless. Symptoms are the best guide for determining injection frequency.

Most people inject 1,000 mcg and the type of B12 tends to be determined by what country you are based in. Here in the UK most people will use hydroxycobalamin.

[jaybirdxNHM in reply to IMINHIM]

Hi, Thankyou for your concern. Im, using Hydroxycobalamin from Germany 1000mcg.

I'm SI with my GPs knowledge and agreement(!!!) I'm following the NICE guidelines of loading doses until symptoms stop improving, a little' trial and error'. GP knows not to bother with re-testing. We never stop learning.

[IMINHIM in reply to jaybirdxNHM]

what is SI ????

[JanD236 in reply to IMINHIM]

IMINHIM si is self injection.

[Curlygal in reply to jaybirdxNHM]

Wow you're lucky, a GP who gives their blessing for SI!!! Have you thought about cloning them? 😃

[jaybirdxNHM in reply to Curlygal]

Wish I could!!

[jaybirdxNHM in reply to Curlygal]

Hi again, It was the cost of the nurses time, that the Dr objected to,but agreed to let nice nurse (not the rude ones) teach me how to self inject, (took 10 mins).He said ''everyone wins''. Cost surgery nil,me £90ish per 100 jabs. I do wish the fine injecting needles were not so firmly stuck in the covers, difficult with dodgy hands!! Onwards and upwards.

[Curlygal in reply to jaybirdxNHM]

That's what you need (what we all need)- a GP with a pragmatic (and flexible) attitude to treatment. Of course so many of them think that as soon as serum B12 is at "normal" levels, everything is fine and any symptoms are due to something else, or a figment of the patient's imagination. Ah well! Glad things are so positive for you 😊