I went two years with PA before diagnosis. Fatigue, depression, despair, parkinson like tremors, and wanted to die... I've had treatment for two years...physically i feel great but i am different in my core being. I am not depressed however my apathy is pervasive in every part of my life. I was an avid gardener, passionate and accomplished artist, teacher, so many interests....now i could care less about doing anything except the going to the gym. My family has noticed my personality is different now....had anyone else experienced this?? Personality changes with PA?