I am hoping for reassurance. Several members of my family have P.A. My husband and three of my daughters and two grand-daughters. There is lots of other stuff going on- 2 daughters with Ehlers- Danlos one with M.S. a grand-daughter with Graves disease just as a starter. My 33 year old daughter has EDS, PA fibromyalgia, the PA was diagnosed by a gastro-enterologist approx 2 years ago who put her on monthly injections after the loading dose. About 6 weeks ago after a GP consultation( her GP is normally fabulous incidentally) it was decided to change her to a different 3 monthly injection - sounded like a good idea. However she is now in an awful state with all the PA symptoms so we managed to get blood tests done yesterday, should be back Tuesday, and if they are down, and I am hoping that will be the case, they will give another injection. Does this scenario sound familiar? She is getting married on Thursday but she is so unwell, have you any suggestions please. I know this is turning into something of an essay, but I would like to know why some have monthly and some 3 monthly injections. My husband has a recent diagnosis, but I strongly suspect has had it for years, he is on 3 monthly injections but struggling after about 8 weeks, any information would be brilliant. I, thank goodness am pretty fit but about at the end of my tether with all my crocks!!