Hello,
So I began taking the Jarrows B12 Methylcobalamin 5000mcg losenges yesterday, and last night my anxiety went through the roof. I couldn't sleep, my heart felt like it was racing, my stomach is upset. Is this normal? Does this go away? Or does this mean my body can't handle the B12? I had a shot on Monday in the doctors office, but didn't have this reaction. I was thinking maybe the 5000 mcg might be too high?
Any thoughts, suggestions, or advice?
Thanks,
Dawn
Problem may actually be the form - some people do have problems with the methylated forms of B12.
The shot you had was probably hydroxocobalamin.
It may be that you have one of the MTHFR genetic variations - these affect the way the body processes some vitamins - particularly B12 and folate - sometimes the body can't process and sometimes it goes into overdrive - depends on the variant.
You might be better of looking at supplementing hydroxo - not sure if you can get this as tablets - you can certainly get it as a nasal spray which works very well for me.
I find that methyl really doesn't work on neuropsychiatric symptoms for me though does work on other problems so if I just take methyl I start getting really cranky, anxious and depressed.
Hi, I know this is an old post sorry! I've been looking through old threads
I suspect I have MTHFR genetic variations as I cannot tolerate methy b12, I have checked and apparently I shouldn't take folic acid if I have this gene, does this mean I should take methyl folate? Is B12 less effective / not effective unless folate levels are high? (I have seen other people post this)
MTHFR affects your bodies ability to methylate vitamins - particularly B9 (folate) and B12. There are at least 2 genes that can cause problems and exactly what the problems are also depends on whether you have one copy (one parent) or two copies (both parents).
What you need to do depends on exactly what genetic variations you have. For some variations methylated forms of both folate and B12 help in by passing the need for the body to methylated forms so you have access to B12 and folate in forms that are needed atthe cell level. However, for some methylated forms lead toa whole load of other problems.
I'm a bit confused. I'm going to do the test but I wouldn't get the results for a few weeks.
Are you saying that if I have certain MTHFR genes it means I will need to take methyl forms of B 12 / folate as it's the best one I can absorb, and if I have other types of MTHFR genes I'd need to avoid it completely? (I'm guessing of the two I'd have the second as I've been having bad reactions to it)
Thank you
I am not an expert - just aware that MTHFR is more complicated than just using methylated forms of vitamins which is often what the commercial hype says.
Some links
I have recently had 3 shots of cobalamin B12 1000 mg shots. The first one was ok, but within a couple hours of and 2nd and 3rd shot I had extreme difficulty breathing. I have stopped all B12 for now, even the sublinguial tablet and liquid as they also gave some difficulty breathing.
A surprise from my last visit to the GI
Anxiety & Depression due to B12 deficiency?
Recent retest B12 over 1,000
Help for Numbness and pain in hand, difficulty walking.
Walking out of GP office with a referral to see a sleep specialist versus B12 levels and symptoms.
