Pernicious Anaemia Society

forgetfulness & b12

After Neurologist appointment for my forgetfulness, I convinced my GP for weekly B12 injections for couple of months.

He requires some evidence to prove that this treatment will surely help me.

Can someone pls point me to any research document which proves frequent injections required to resolve neurological symptoms.

Thanks to all wonderful people here.

7 Replies

I don't have time to look now, but if you do search, make sure you get articles from recognised medical sites/journals, or he may dismiss the evidence out of hand. Hopefully someone else here can help with links


It might just be me but isn't it the doctor's job to find out why you have forgetfulness and if you say it improves with b12 then he should go and look up the research if he needs 'evidence?

Please,feel free, tell him I said that.

There isn't anything in particular about forgetfulness in it but give him the BMJ article that tells him cognitive issues can be caused by b12 deficiency.

Then tell him to pay half his wages back to the NHS because he's not worth the money.


LOL - 'Atta girl!


Not articles - but assuming you are based in the UK you could try pointing him at the NICE guidelines.

The neuropsychiatric includes 'dementia' which would cover forgetfulness and other cognitive impairment

Probably important that you make GP aware that anaemia is a symptom of B12 deficiency - not a cause or even a defining characteristic - and seems to not be present in a lot of people - particularly if folate levels are good.

also under investigations

it is saying that there isn't actually a good test for B12 deficiency and because of the dangers of permanent neurological damage treatment should be on the basis of clinical presentation not test results.

The guidelines reference various studies.

You can't overdose on B12 - again, assuming you are based in UK and will be treated with hydroxocobalamin - the treatment for cyanide poisoning is 5000x the amount you will receive as a shot administered over 15 minutes - with a second dose after 30 minutes if needed.

Unfortunately most of the B12 ends up being removed from the body in the Urine but ...


Hi hiteshhp ,

I would be good for you to read and give a copy to your GP of the latest British Society for Haematology's Guidelines for the diagnosis and treatment of Cobalamin and Folate disorders; see:

Kind regards,


1 like

Got an indirect link here so let's see how this works for you:

In the BMJ article there is a statement saying that B12 deficiency can lead to spastic ataxia.

I then found another link on ataxia mentioning memory loss.

The links between the original article mentioning the ataxia and the actual symptoms are pretty much amazing in summing up a lot of the symptoms of B12 deficiency.


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