In this video, Elliot of EONutrition succinctly explains the rational behind high dose thiamin therapy as a tool for bypassing metabolic blocks caused by factors unrelated to nutritional deficiency.
And he examines with well chosen illustrations how this approach could be a useful therapy for chronic health conditions characterized by mitochondrial dysfunction.
You cannot wish for a clearer explanation🌺
Amazing video. All make sense.👏👏👏. Thank you for sharing
Doctor Antonio Costantini is quoted in second half of the video.
Very interesting B1 presentation. However, he kept talking about Mega and HDT, but never mentioned what that mega or high dose is except for MS patients. My husband still experiments different doses and still not sure what the "magic" one is. He also didn't mention that each patient is different, therefore, requiring different dose of Thiamine.
This is the first time I have heard a possible explanation of why HDT seems to work, at least for some people. I worked well for me for about 6 months, then became less effective. Note that if part of the cause of PD is oxidative stress and neuroinflammation, then HDT will be acting on one of the consequenses of the cause rather than the cause itself. Could this be why it works well for early stage PD or only for a limited time?
However there may be a case for combining HDT with antioxydant and anti-inflammatory therapy ( such as activating the Nrf2 pathway with isothiocyanates from broccoli seeds) and treating both the cause and the consequences.
I looked up his website. It's a private medical business like you find in the USA, not inexpensive !!!
Dr. Lonsdale's book on thiamine contributed to Ellit's knowledge of Thiamine early on.
amazon.com/Thiamine-Deficie...
"Constantini hit the nail on the head with one quote from another paper:
'We may suppose that symptoms decrease when the energetic metabolism and other thiamine-dependent processes return to physiologic levels. Our aim was not to correct a systemic deficit of thiamine, but rather to increase the activity of enzymes involved in cell production energy in selective brain regions; '
Indeed, Constantini understood that thiamine could be used as metabolic enhancement to stimulate the enzymes involved in energy metabolism which had otherwise been inhibited by other factors. This is where we are dealing with a “functional deficiency” which can only be addressed by supraphysiologic concentrations to saturate the cell for improved bioenergetics.
As I said mentioned previously, Dr Derrick Lonsdale has highlighted on many occasions how thiamine’s effectiveness is due to its pharmacological action, rather than nutritional repletion.
Rather than remaining hyperfocused on correcting a deficit, we can be using this molecule to improve bioenergetics regardless of nutrient status. This means that someone does not necessarily need to be nutritionally deficient to benefit from thiamine supplementation at high doses. "
Declining effectiveness is not universal. High-dose thiamine continues to work for me almost 3 years after starting.
For me it's been working for 5 years and I see a lot of difference between not taking it. It certainly does not resuscitate dead cells and does not prevent an organ such as the brain from aging which is already compromised by the disease.
As I've always said with HDT it's best to stay well fed, eat fresh vegetables for minerals and vitamins, exercise whenever possible, and use ldopa.
A lot of help, spirituality, art and beautiful things and a lot of love for people and life will still be worth living a little longer.
Forget the text of wikipedia, it's just bullshit and admire the work of art of Gustav Klimt
I've been stating magnesium being needed as a required co-factor for HD Thiamine protocol for a while now. Elliot elaborates here the underlying mechanisms and why Mg deficiency can be problematic. The same also applies to other required co-factors (other B's, zinc, etc) so this should be taken into account while understandably wanting to monitor the incremental effects against various rate-limiting factors that could contribute to metabolic blocks.
very interesting discussion to which I add research on the thiamine antioxidant effect and is the role of intra cellular Ca ++ (calcium).
Here it is for genre lovers:
“Thiamine and oxidants interact to modify cellular calcium stores.
Hsueh-Meei Huang, Huan-Lian Chen, and Gary E. Gibson.”
Thanks
hello, our son has essential tremor and we are looking for a Doctor who can advice right dose to start.
Can’t help with a doctors contact. Do not know of any functional medicine specialist myself.
Maybe you can contact Elliot from his bio page. You have the options of telephone, message, FaceTime and email.
Link here: eonutrition.co.uk/about-me
🌺
thank you very much
Stopping high dose thiamine therapy after just a month
Dr. Costantini's High Dose Thiamine Recommendations. 
Starting High Dose Thiamine 
Thiamine Hydrochloride for Parkinson
