Curcumin seems to have protective eff... - Parkinson's Movement

Parkinson's Movement
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Curcumin seems to have protective effects in Alzheimer's disease. Could it be good for PD?

This long article looks at how curcumin interacts with the amyloid beta protein and seems neuroprotective in a human trial of AD. I don't understand it all, but could it do the same for a-synuclein in PD?

I hope someone who knows more about the science than me can give the forum an informed opinion.

I get proposed several articles like this a week on Researchgate as feedback from articles I read or search for. It's obviously using the same algorithms or cookies as Google uses to send you publicity. This is however useful as I get to see the latest stuff without much effort. Most of it is also free access or if not I can directly ask the authors to send me a copy and they usually do.

Take a look

researchgate.net/publicatio...'s_Disease

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Hello, Albert!

I know one thing: Dr. Mischley has identified it as one of the four must-have supplements for PD.

One of the best supplements in the market is "Theracurmin HP" by Integrative Therapeutics.

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I've just started on a highly concentrated curcumin supplement. It's made by a small company just 10 km from where I live and is claimed to have very high bio-availability. They seem quite competent and open. You can even visit the laboratory. It's not cheap.

nutrixeal.fr/Mobile/curcuma...

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Albert,

I can't read French, but I do trust your judgment. The Theracurmin HP, we get isn't cheap either, costs approx. $90.00. :(

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Hi Wriga, If it is valid as you say, I will try to buy it too because Despe's Theracurmin HP cannot buy it from Italy. What is the dosage per day of CurcumActif 2? Thanks

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I don't know if its valid. It seems to me to be worth a try. I'm mixing it with omega3 in a two pronged approach.

It says 1 to 3 x 500mg per day on the box.

I'm doing 2 x 500mg per day for a month to see. If you read the description, that's a hell of a lot of curcuma powder at 6 times the bioavailability.

I'm not promoting this or any other. Just saying it exists and I'm giving it a try for its antioxidant activity alongside a Mediterranean diet. I bought the smallest packaging, 30 gels. There are larger sizes which work out a bit less expensive. I also bought some at 250mg to be able to adjust the dose.

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Thanks Wriga, I just bought two packs of 500 mg. at Nutrixeal. I don't know how long to take them. A month seems to me little in our conditions.

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I agree Fed, I'm just not pushing the idea that it's validated. That will take 6 months to be sure. I think the Mediterranean diet is also an essential baseline condition.

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What were the other 4 Despe?

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Hi Jeeves,

My answer is below (Pixel). How are you doing?

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Hi Despe. Not bad thanks but have a really stiff and painful foot which I don’t know what to do with. Maybe these supplements might help? Best wishes to you😊

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Hi, Jeeves.

Have you tried mag oil applied directly to your foot and ankle? It reduces pain, is anti-inflammatory and relaxes muscles and joints, can reduce swelling such as with a sprained ankle and will make it feel better very fast, while being inexpensive and easy to get. It can also relieve cramps quickly, which are so common with PD.

Many people think that a high quality magnesium supplement can do all that mag oil can do, but plain and simple, that is wrong.

Art

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Hi Art. Thanks for you kind concern. I’ll try it. Is this mag short for magnesium? Amazon I presume?

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The link below takes you to an inexpensive 8 ounce spray bottle that will be plenty enough for you to test it inexpensively and find out if it is helpful for you. The correct name is magnesium chloride oil. It is also available in oral capsules which is also well absorbed, but the spray is what you want.

Art

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Thank you! Hadn't you started these supplements? Following Art's incredible search and insight, I have added AMLA. It's worth looking into it. :)

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God Despe I’ve tried everything in my time but probably expect a quick fix so after 3 months tend to move onto the ‘next big thing’. A character flaw no doubt but I think that I could supply Amazon, with the amount of half used supplements that hang around my kitchen 😂

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Hi Jeeves! Believe me you are not alone. We are all making AMAZON richer. :lol:

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Hi Despe,

We should not worry about making Amazon richer. Amazon is only one link, albeit an important one, in the circuit of what we are doing on this forum. In this circuit we are trying to build and check on information relating to ways to reduce the burden of PD. Internet is the greatest ever invented for this. It allows things to happen a thousand times faster than before. We get access to research that was previously reserved for professional researchers, right here in our living rooms. I have hundreds of articles right now on my phone. We can share them, discuss them, criticise them and build up our knowledge and understanding. And like all researchers, some of us like to do experiments. For that we need provisions. Amazon is my primary supplier of first time medical supplements. They are rapid and reliable. When Amla was discussed last week, I didn't hesitate to see if Amazon could provide it. My order is on it's way from India. Imagine the effort to try to get that directly. Over time I expect to see more plant based suppliers making products that work even better. Amazon may get richer, but we will have more choice. And big Pharma could be the big loser.

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Agree with you, Wriga. Purchasing on line from Amazon makes it easier for security reasons. I don't have to give my CC nr. to a variety of suppliers. . .the more suppliers, the riskier for hackers to hack your CC. It actually has happened to me three times. :(

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Ditto, boxes. Finally started ordering just what I use.

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Hi Despe, could you tell me what, according to Dr. Mischley, are the other essential supplements for PD? What is the dosage? Thanks

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Dose depends on a lot of factors. If you follow the recommended dose on the bottle, you will be safe. However, PwP require higher doses, use your own judgment.

Pharmax or Metagenics are both good quality fish oils. Qunol COQ10 liquid is the one recommended by Dr. Mischley.

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I’m curious what the other three “must have” supplements are?

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Fish Oil, COQ10 (liquid forms both for best absorption), and Intranasal or liposomal Glutathione. Intranasal glutathione is by prescription only, the liposomal (a good one), can be purchased on line. Hope this helps.

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Despe,

I recently added a post to the Amla / Glutathione thread that has a link to a study that suggests that Amla is more effective than liposomal glutathione at raising blood glutathione levels and amla is less expensive! I also put another post where the study showed that straight glutathione is less effective than amla at raising blood levels. Both posts are near the bottom of the thread.

When you add in all of the other health benefits associated with amla, it just seems like an easy choice! I am not clear on this point yet, but it appears that amla can also have effects that maybe somewhat similar to Co-Q10 and if that is correct, it would be nice to have access to a less expensive alternative to Co~Q10, but I will have to read further to see if that is correct or not. If/when I find out, I will post it here.

Art

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Art,

Good idea. Which brand you ordered?

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Art,

Sorry for my question, you mention before- you not recommending a specific supplier. I forgot...

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Thank you, Art! I haven't received replies to my comments for the last two days (I believe). Therefore, sorry for my delayed answer. Same goes to Jeeves. :( I look into to your new links. As I mentioned, I emailed Dr. Mischley regarding AMLA but she hasn't replied yet. They (Seattle Integrative Medicine) actually have it and can be purchased on line. I assume if they sell it, she must be familiar with the benefits.

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Despe,

I think in her case with all of the years of experience that she has, she may feel most comfortable recommending what she has experience with. Unfortunately, she should be aware of those studies on amla / glutathione, because the studies I linked to suggest that amla is a better booster of glutathione and it has very strong antioxidant activity and it can recycle other antioxidants while having a fairly strong anti-inflammatory effect among many other health benefits!

I must admit the Lipo-glutathione study was a bit of a shock to me! I was expecting a much stronger response from it and then there is the cost factor as it seems that Lipo anything is going to be pricey!

Art

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Art, I just couldn't wait for her insight and recommendation. :) I ordered the powder and supplements. Powder is by TERRASOUL and supplements are by TATTVA'S HERBS. Powder is added to grain-free cereal with Mannitol and some other adds-on natural antioxidants (blueberries, cinnamon, dark chocolate Lion Mane powder and walnuts). After breakfast and supper, he takes the supplements.

Does Amla give gas? :) He complains about excessive gas, hahaha. :)

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There are so many other things in that powder blend, it would be hard to say what ingredient might cause gas. When I used the amla extract at the study dose, I did not have gas, but mine is just the extract form similar to what was used in the study. I would think if the tested amla gave people gas, they would have made mention of it and I didn't see that effect in any of the studies. I notice that all of the 59 participants in the first study, completed the study which leads me to believe that gas was not an issue or there would have been dropouts among those 59 participants. I went back and looked and there was no mention of gas, but three participants in the placebo group reported diarrhea.

My thinking is that all of the benefits of amla is more of a long term treatment, with health benefits that we all can use!

Art

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Despe,

It was few post about excessive gas from Mannitol.

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Yes, I know Mannitol is most likely the cause, but that doesn't happen every day.

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Her Seattle Integrative Medicine website lists her preferred supplements .

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Is there a preferred brand for the Glutathione?

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It's by prescription by Dr. Mischley. Liposomal, you can get it on line, SilverQuick is a good one, a bit expensive.

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I'm guessing you meant QuickSilver? A search turned up QuickSilver but not SilverQuick.

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:) You're right! Name transposed.

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I'm not scientifically oriented, but I believe curcumin was one of the most important supplements I used in my pre PD days, and believe it is responsible for my long 'honeymoon' period of about 15 plus years. Cinnamon too...

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How much do you take daily please

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500 mg

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Can you take a natural form of cucurmin?

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An easy, fun read, Growing, Harvesting, and Manufacturing Curcumin @curcuminforhealth.com, will help explain why the natural form probably wouldn't work.

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Fabulous honeymoon @Kerrington! I am hopeful...

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A good reminder about Curcumin. Thanks Wriga.

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I am trying not to get upset or disgusted with the endless hype about substances that can alleviate, cure or regress Parkinson’s. I am talking from a position of vast knowledge and experience with much of the Ayurvedic stuff and knowledge that is being peddled around these days.

I grew up in a semi - ultra orthodox Hindu Brahmin household that practiced the holistic Hindu way of life. Turmeric was part of the daily food and part of the rituals where it is a prime component. Additionally, there are other herbs and spices that are also a major part of the diet. I have been having turmeric every day for over 50 years and yet I still got Parkinson’s. I had coffee for most of my life and I am talking about several cups a day. I practiced yoga, meditation and everything else that you can think of as helping Parkinson’s and yet here I am.

Color me skeptical.

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Hi Cholavaram,

You may be right, but PD isn't the same for everyone. Let's see how other people respond.

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It's a virus, you got a virus, we all got a virus. That is my strong belief.

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I took a look at your profile. . .all your posts are about meds. . .you are asking members of this forum medical questions. Most of your replies are "Thanks."

In addition, you wrote nothing about yourself, your diagnosis, and your meds.

Are you a PwP?? If you are, what meds are you on?? Thanks!

PS. To be honest with you, I don't believe you have Parkinson's.

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lol, you are a smart one Despe and you do a wonderful job of taking care of your husband. I used to be Ramesh Malayappan in my previous profile. I deleted my profile in anger one night after I made a fool of myself at the high stakes interview with the tech company that I wrote about. Remember that? That experience and day was painful.

Many of you offered me advice, but in the end, what did me in was a bad combination of Rytary and Mucuna that I reacted to so badly that I ended up stuttering, stammering and apologizing while all the while looking like an idiot. I used to command board rooms with very senior people at one time. That night when I came back home, I was inconsolable.

I felt at that time that I was spending all my time on HU to the point of obsession. I was on disability at the time and all the time at home. I thought I was losing my mind. Adding to the pain was the passing away of my father in July. I was distraught.

I have since started on a path to where I think I can be normal as I can be and I am also back at work after quitting disability. Somewhere along the way I missed you guys (Marc Anderson, John Pepper, you, and everyone else). So I decided to “sneak” my way back in and since I know so many of you, I thought I could stay anonymous.

However, smart members like you are always vigilant and I am grateful and glad that you do. It is important to keep the trolls out and I am happy to see that there are ever vigilant eyes.

I will update my profile accordingly. To answer your question, I am on Rytary. Still tweaking. Unfortunately. food, any food, even the tiniest amount throws me off completely. I am unable to recover from the sequence of events that follows a small meal or snack. So, I fast during the day at work and then I eat all at once in the night.

Cheers!

Ramesh

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"Malayappan" yes, I remember that user name. I wish I was right and you didn't have PD.

Cheers :)

PS. Thanks for the compliment.

PS1. Sorry for your loss. I lost both of my parents within the last 3 years.

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I wish so too ! Sometimes these medications work so well that I start to believe that. If only, the meds delivered consistent results.

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Stay in touch and update your profile please. You sure fooled me. :)

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I already started to. I will expand more later.

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Super!

I also remember you asked forum members' advice for an interview, go for it or not? Does my memory serve me right?

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Yes indeed. You are right.

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LoL, there was a typo in the original message. Autocorrect did it.

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I do remember you and am so glad you decided to return!! We are a close group and I too would miss all of you if I left! Welcome Back!! Connie 😊

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Thanks, ConnieD!!

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I remember you too, and have often wondered what happened. Now I realize you'd had a very stressful time, and I'm very sorry.

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Thanks. Don’t feel sorry. It was a learning experience and I am better for it and feel blessed to have a supportive online community. It is so important.

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If they don't help, why bother? Stop and continue with whatever meds you take. . .

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I don’t have anything else. Sinemet gives me terrible dyskinesia and dystonia.

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You are right, The well-known things are repurposed as drugs and make them costly. similarly, Curcumin is supposed to be antibacterial and work against TB. however, in vitro culture studies show curcumin does not kill TB bacteria. Proving such things in PD is going to be difficult. For Patients, hype becomes the only hope. it is due to media which always hype, concentrate on a statistical study than a mechanistic study. Much of science loses due to media overdrive. the scientist who asks questions now become skeptics and quacks who hype things and throw false hope are saviors of humanity.

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We last had a (brief) discussion about curcumin (in the form of Theracurmin) about a year ago, following a very positive AD trial.

healthunlocked.com/parkinso...

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My husband’s DNA analysis by opus23 said for him to avoid turmeric and cumin due to his cyp1A2 and MAO-A genes snps. And grapefruit.

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I have written extensively on Theracurmin as it the only Bio-available form of Curcumin with a human clinical trial although the trial was done by the manufacturer so one needs to keep that in mind.

Here is a link to a large amount of research directly related to Parkinson’s:

healthunlocked.com/parkinso...

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Thanks Joe,

That's an awful lot of detailed reading and understanding to get through. Is there a decent summary somewhere to help me get started ?

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Sadly, as you well know this type of information is purely speculative, because what we have is research in the lab and research not for Parkinson's and then we are expected to draw our own conclusions. The human clinical trial looked at patients with Alzheimer's over 18 months (I'm going on memory here so I may be off on that). Anyways, the big deal was the researchers looked at toxic protein aggregates and the patients who took 2 pills a day of Theracurmin had fewer protein clumps and better cognition than the placebo group . . . so I take 2 Theracurmin pills per day, one in the AM and one in the PM. I take Theracurmin because it is a "nano" particle and those types of particles were proven by independent research to be vastly superior in terms of actually reaching the brain versus any other curcumin supplement. That is why Theracurmin is so expensive. They use patented technology to make the curcumin more bioavailable. There are other companies that make other forms of curcumin that claim greater bioavailability, but I have not seen research anywhere showing anything better than Theracurmin. That doesn't mean it's not out there; it just means I haven't seen any such research yet so I stick with Theracurmin.

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Just getting to this 🖐

pulling the next “string”...🧶

thx Sunny ☀️ @sunvox

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Thanks Joe,

I know know what I need to read up on over the winter months. Keep us posted.

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Here's a paper reviewing studies of the bioavailability of various curcumin formulations. Interesting information, though the author concludes, "Extensive variability in the studies makes it difficult to directly compare and conclude which formulation is better than the other."

researchgate.net/profile/Ro...

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Thanks asecondforever,

We are now getting to a period where there is an overload of information coming out on research on plant based medication. What I believe is important though is that data available to us on this sector of research is growing and could well overtake that of data from big pharma, which remains largely unpublished. This is to our benefit, since we can easily access plant based supplements and carry out our own personal trials, wheres we can't get hold of patented molecules. Big Pharma could be the big loser in this quiet revolution.

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I have been using Swanson's Tumeric Phytosome for over a month now. I started using it after not tolerating levodopa,carpidopa, entacapone well. It really helps me immensely and calmed my tremors in about an hour. I hope it continues to be effective . There were no ill side effects for me.

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Hi Jarb,

This may be an important observation you make here. It is the first time I hear that Curcumin may have a short-term effect on tremor with an effect after only 1 hour. Can you expand ?

How much curcumin is there in your dose of Tumeric?

Do you take it alone or with other meds?

How often do you take it ?

Is this product labelled as a highly absorbed version of Curcumin ? Etc.

Has anyone else observed this effect ?

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Swanson's bio availability is increased dramatically by Meriva. The bottle says that it contains 18-22% curcuminoids. I have been using 2 per day. I also use Life Extension Dopamind (1/day), and fisetin (1/day). I don't take any PD meds except HDT. I started that a few days ago and made my symptoms worse, so I need to work on adjusting dosage.

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Is this what you're taking ? 500mg capsules.

amazon.com/Swanson-Turmeric...

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Yes, exactly.

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