All you need to know about Exenatide - Parkinson's Movement

Parkinson's Movement

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All you need to know about Exenatide

Kia17
Kia17

The much anticipated results of a phase 2 clinical trial of exenatide have been published in The Lancet, and have since appeared widely in the media. The findings offer hope that drugs like exenatide can slow the course of Parkinson’s — something no current treatment can do. So, generally how does exenatide work?

byettahcp.com/science-of-by...

What is Glucagon-like peptide 1?

Glucagon-like peptide 1 is a hormone produced in the gut and released in response to food. It causes reduced appetite and the release of insulin.

yourhormones.info/hormones/...

26 Replies
oldestnewest

Interesting. So this is a diabetes drug. But then instead of this you could just go low carb or Keto. I also think Mannitol slows progression. As might B1. As does exercise.

Is this the right link? Nothing in this link about the study.

Kia17
Kia17 in reply to MBAnderson

Hi MBAnderson

The study has already been posted in the HU, this link is about the Exenatide pharmaceutical properties.

Thanks

Kia

MBAnderson
MBAnderson in reply to Kia17

Thanks. I missed it.

gaga1958
gaga1958 in reply to Kia17

whats HU?

Despe
Despe in reply to gaga1958

HealthUnlocked, the name of this site.

I’ve been on it, in all, just over 8 months.....the doseage I’m on is 2mg.

I see the photo is 10 mg. I’m feeling better but I’m also on 1000mg Vit B1.

Only started the B1 about 1month ago and it’s after that that I am now feeling better.

Wonder if I could get the 10mg shot here, Down Under.???? Told 2mg was the limit.

I’m optimistic.

Too frail for exercise as my balance is not balanced and I fall....lots....BUT I have a physiotherapist coming tomorrow for a home visit who will take me through our Gym set up and find the one I can use. I’m hampered for some, because of stiff knee from complete knee replacement and I won’t TORTURE myself into using them.

Hoping something will suit. The rowing machine I have tried and that was comfortable......weights ??

HGE

I would be afraid to try Exenatide. My personal experience with trying new medicines has mostly been negative. I tried Gabapentin 100 MG at one tablet at night for one week, then two tablets at night for a week. I developed swollen legs and quit taking it. I am taking Senemet and have added B1 in the past month or so. I seem to be a bit better after taking the B1, but not dramatically better. I've recently added liquid B-12 with B-complex. I haven't taken the vitamins long enough to find out if they will help.

glenandgerry
glenandgerry in reply to sleezy

Why did you take Gabapentin? Was it for peripheral neuropathy?

sleezy
sleezy in reply to glenandgerry

My doctor decided that I have restless legs and that was the reason for the Gabapentin prescription. However, I have only about an hour of "restless feet" each day after the last dose of Senemet has been taken. I thought it might possibly help me fall asleep faster at night. It didn't seem to help me fall asleep faster. I quit taking it when my legs started swelling. I am very sensitive to medicines and seem to get an unusually amount of side effects.

answerseeker
answerseeker in reply to sleezy

Mmm, have you tried magnesium with dinner? Some people find topical magnesium oil massaged into calf and foot helps or a foot soak with 1 cup of Epsom salts help.

sleezy
sleezy in reply to answerseeker

I might try soaking my feet in warm water, using Epsom salt. Thanks for the suggestion. I try to use methods of treatment with the least amount of side effects.

Many articles about Exenatide studies have been published in the last 2 years. I have 30 stored in PARKINSONS ONLINE (going back to 2013). The best 14 articles (outlined below). For anyone interested, I would be happy to forward these to you, if you send me your email address. frank.mundo@gmail.com. Date prefix in title dates article (eg 1805 = Aug 2018)

1.The BIG PICTURE

1612 The road ahead – Parkinson’s disease research in 2017

1801 The road ahead – Parkinson’s disease research in 2018

2.Exenatide is an FDA Approved drug used to treat diabetes. First test involved small group of PD patients injected twice daily.

1301 Exenatide as a Treatment for Patients with Parkinson’s Disease | Parkinson's Disease

1305 Exenatide and the treatment of patients with Parkinson’sdisease

3.More information abt this new trial approach, lower cost, for repurposed drugs

1306 A new approach to disease-modifying drug trials

1306 Exenatide and the treatment of patients with Parkinson's disease. - PubMed - NCBI

4.Diabetes relationship to Parkinson's, repurposing of diabetes drugs for Parkinsons

1612 A drug from Kalamazoo

5.Exenatide one of the repurposed drugs . . .

1707 Repurposed Therapies in Parkinson's Disease

6.Latest development, Phase II completed, efficacy is established

1708 Exenatide: One step closer to joblessness!

1708 The Science of Parkinson's disease: Exenatide: An editorial

1708 Is Exenatide a Treatment for Parkinson’s Disease? - IOS Press

1710 Miss Grand Challenges in Parkinson’s Disease and Rallying to the Challenge? We have you covered. - VAI

1804 SR-Exenatide Being Developed for Parkinson's in Peptron, NIH Agreement

1805 Korean-based Pharma Advances Clinical Trial of SR-exenatide in Parkinson's

sleezy
sleezy in reply to FMundo

i appreciate the information, but I'm not wanting to add another medicine to my schedule at this time. I'm using B1 and hoping that will help me.

sunvox
sunvox in reply to sleezy

The format of this forum makes it difficult to see to whom someone is responding, but if you look at the indenting you will see he was not responding to you, but rather the Original Poster or OP.

Kia,

The real answer is researchers are not sure, but what they do know is that Exenatide is something called a GLP-1agonist. That's a fancy way of saying it has a beneficial effect on several important cellular processes. When different cells in the brain begin to die because of the presence of toxic alpha-synuclein several different processes become affected. That's why when you read research papers you see all kinds of "rescuing" going on: MAPK, mTOR, GSK etc. These are all cellular processes that get messed up when cells in the brain start to die, and it appears Exenatide somehow keeps cells alive and thus all these various cellular processes keep going which in turn results in fewer symptoms. Researchers are asking the question of whether or not Exenatide has any impact on the underlying cause(s) of Parkinson's. I have not found any evidence in the animal and cellular research that would indicate it does. If true that would mean it is another symptom treatment and not a "cure", but really it is too early to say for sure.

Kia17
Kia17 in reply to sunvox

Hi Joe

I think the foundation of using Exenatide for the “PD treatment , cure or delaying progression “ is based on the insulin resistance senario which seems rational to me. I think that the Exenatide solution has been approached and addressed through different ways such as Ketogenic diet or Thiamine or Niagen ,,, etc.All approaches have something in common which shows that the PD related to a lack of cellular energy. Since all these helping in increased cellular energy the differentiation between different pathways is hard and would need years of research. But for now I believe that everyone agree with any treatment that enhances the mitochondrial functionality with less side effects until scientists find a cure.

Kia

Bridielena
Bridielena in reply to sunvox

I really believe it’s helping me enormously but what dosesge is the correct one. I believe here in Australia the limit is 2mg. I also believe you can get 10 mg. Not here yet. I have an injection once a week.

Kia,

I love the fervor you bring to your posts, and I hope you will forgive me for being negative, but I feel one role I play on HU is to counter balance information I feel is wrong. As such I want to say your implied emphasis on insulin resistance as being the primary factor with regards to Exenatide is misplaced, and your mention of thiamine and niagen and insulin linked together is vastly misleading, and is demonstrative of a gross misunderstanding of the matter.

sciencedirect.com/science/a...

Kia17
Kia17 in reply to sunvox

Thanks for your input Joe.

I never said that Thiamine, Niagen or Exenatide work the same way. I only said that the PD problem lies in somewhere related to lack of cellular energy and these approaches help to restore energy with different mechanisms. One with correction of blood insulin and glucose level ,the other one with its effect on NAD ,,, and so on.

Kia

Have you read this paper from end to end? If not I urge you to do so.

ncbi.nlm.nih.gov/pmc/articl...

Taken together, increasing brain NAD+ levels—either by consuming a KD or by other ketone-enhancing treatments—might serve as a rapid and enduring strategy to halt or even reverse disease progression.

JANVAN
JANVAN in reply to sunvox

Hi Sunvox ! And do you know if the ketogenic diet has to be strikt or

can it be moderate ??

sunvox
sunvox in reply to JANVAN

I do not believe a Ketogenic diet is good. The paper I list above explains in great detail that a ketogenic diet works because it increases the production of NAD. Take Niagen and skip the diet.

JANVAN
JANVAN in reply to sunvox

Hi Joe, just writing and reading your post again : how do you measure your level

of NAD+ ??

Hi Giocas !

And how many B3 , accommodate to the body weight ??

I have flushfree pills of 250mg.....

Just need to tell you that this time on Exenatide into my 3 Rd month , I was feeling like wow we’re onto something with Exenatide then, 3 weeks ago, I had a situation where I had to pack up my Apartment, arrange, my new address all on my own. I have a selfish family and because they only see me at my best figured I was alright Jack. I wasn’t that weekend. Other business problems created in me a bit of a breakdown

My Parkinsons returned to the bad old days.

Now I think I’m on the way up again

I believe STRESS played its part in my situation

I know I’ve got to focus on looking after me. Widowed 8 months ago , so problems still to overcome there. Apologies for this long winded ordeal.

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