My wife has PD and takes a very low dose of Sinemet. While it helps her with movement it also causes her to "peak" as I am told. When this happens she will appear over medicated for a couple of hours after taking the med. Voice gets very low, eyes get very big and she is out of it for lack of a better description. It is almost as though she is getting too much into her system. We have tried er, cr versions and even Rytary to help smooth out the delivery but we still see the effect. Is anyone else seeing this?