Based on these non-motor (and some motor aspects), the most accurate way to divide patients was into three groups – diffuse (many non-motor symptoms), pure motor, and intermediate (halfway between the other). We then followed patients over time. The diffuse group had, by far, the worse prognosis. This was not only for the non-motor aspects, but the motor as well.
Most importantly, we can start to stratify patients into groups and predict their prognosis, based especially upon non-motor aspects of disease.
Not all patients are the same – if you are seeing mild cognitive changes, REM sleep behavior disorder, orthostatic hypotension and predominant gait dysfunction, prepare for a dramatically worse progression of disease, and be especially vigilant for cognitive changes.